scholarly journals Methodology for System Adaptation Based on Characteristic Patterns

10.5772/25816 ◽  
2012 ◽  
Author(s):  
Eva Voln ◽  
Michal Janoek ◽  
Vclav Kocian ◽  
Martin Kotyrba ◽  
Zuzana Oplatkov
Keyword(s):  
System Adaptation

scholarly journals Car braking effectiveness after adaptation for drivers with motor dysfunctions

2021 ◽  
Vol 11 (1) ◽  
pp. 617-623
Author(s):  
Adam Sowiński ◽  
Tomasz Szczepański ◽  
Grzegorz Koralewski
Keyword(s):  
Efficiency Index ◽  
Mathematical Function ◽  
Test Results ◽  
Braking Performance ◽  
Braking System ◽  
System Adaptation ◽  
Parametric Description ◽  
Limited Power ◽  
Braking Force ◽  
Selection Of

Abstract This article presents the results of measurements of the braking efficiency of vehicles adapted to be operated by drivers with motor dysfunctions. In such cars, the braking system is extended with an adaptive device that allows braking with the upper limb. This device applies pressure to the original brake in the car. The braking force and thus its efficiency depend on the mechanical ratio in the adapting device. In addition, braking performance depends on the sensitivity of the car’s original braking system and the maximum force that a disabled person can exert on the handbrake lever. Such a person may have limited power in the upper limbs. The force exerted by the driver can also be influenced by the position of the driver’s seat in relation to the handbrake lever. This article describes the research aimed at understanding the influence of the above-mentioned factors on the car braking performance. As a part of the analysis of the test results, a mathematical function was proposed that allows a parametric description of the braking efficiency index on the basis of data on the braking system, adaptation device, driver’s motor limitations, and the position of the driver’s seat. The information presented in this article can be used for the preliminary selection of adaptive devices to the needs of a given driver with a disability and to the vehicle construction.

scholarly journals Staring at the Naked Goddess: Unraveling the Structure and Reactivity of Artemis Endonuclease Interacting with a DNA Double Strand

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3986
Author(s):  
Cécilia Hognon ◽  
Antonio Monari
Keyword(s):  
Dna Cleavage ◽  
Catalytic Mechanism ◽  
Dna Lesions ◽  
Cleavage Reaction ◽  
Dynamic Simulations ◽  
Important Target ◽  
System Adaptation ◽  
Dna Strands ◽  
Dna Strand ◽  
Dna Substrate

Artemis is an endonuclease responsible for breaking hairpin DNA strands during immune system adaptation and maturation as well as the processing of potentially toxic DNA lesions. Thus, Artemis may be an important target in the development of anticancer therapy, both for the sensitization of radiotherapy and for immunotherapy. Despite its importance, its structure has been resolved only recently, and important questions concerning the arrangement of its active center, the interaction with the DNA substrate, and the catalytic mechanism remain unanswered. In this contribution, by performing extensive molecular dynamic simulations, both classically and at the hybrid quantum mechanics/molecular mechanics level, we evidenced the stable interaction modes of Artemis with a model DNA strand. We also analyzed the catalytic cycle providing the free energy profile and key transition states for the DNA cleavage reaction.

scholarly journals User Experience May be Producing Greater Heart Rate Variability than Motor Imagery Related Control Tasks during the User-System Adaptation in Brain-Computer Interfaces

2016 ◽  
Vol 7 ◽  
Author(s):  
Luz M. Alonso-Valerdi ◽  
David A. Gutiérrez-Begovich ◽  
Janet Argüello-García ◽  
Francisco Sepulveda ◽  
Ricardo A. Ramírez-Mendoza
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Motor Imagery ◽  
User Experience ◽  
Brain Computer Interfaces ◽  
Computer Interfaces ◽  
System Adaptation

scholarly journals Chaotic Behavior in Gear System. Adaptation of Bifurcation Diagrams and Method of Statistical Mechanics.

1995 ◽  
Vol 61 (587) ◽  
pp. 3108-3115
Author(s):  
Keijin Sato ◽  
Sumio Yamamoto ◽  
Kazutaka Yokota ◽  
Toshihiro Aoki ◽  
Shu Karube
Keyword(s):  
Statistical Mechanics ◽  
Chaotic Behavior ◽  
Gear System ◽  
Bifurcation Diagrams ◽  
System Adaptation

scholarly journals Teaching about climate change in medical education: an opportunity

2016 ◽  
Vol 5 (1) ◽  
Author(s):  
Janie Maxwell ◽  
Grant Blashki
Keyword(s):  
Climate Change ◽  
Medical Education ◽  
Teaching Methods ◽  
Climate Change Mitigation ◽  
Learning Objectives ◽  
Societal Transformation ◽  
Graduate Attributes ◽  
Assessment Tasks ◽  
System Adaptation ◽  
Change Mitigation

Climate change threatens many of the gains in development and health over the last century. However, it could also be a catalyst for a necessary societal transformation to a sustainable and healthy future. Doctors have a crucial role in climate change mitigation and health system adaptation to prepare for emergent health threats and a carbon-constrained future. This paper argues that climate change should be integrated into medical education for three reasons: first, to prepare students for clinical practice in a climate-changing world; secondly, to promote public health and eco-health literacy; and finally, to deepen existing learning and strengthen graduate attributes. This paper builds on existing literature and the authors’ experience to outline potential learning objectives, teaching methods and assessment tasks. In the wake of recent progress at the United Nations climate change conference, COP-21, it is hoped that this paper will assist universities to integrate teaching about climate change into medical education.

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