scholarly journals Prognostic Factors in Soft Tissue Sarcoma

10.5772/25742 ◽  
2011 ◽  
Author(s):  
Luiz Eduardo Moreira Teixeira ◽  
Jose Carlos ◽  
Ivana Duval De Araujo
Keyword(s):  
Prognostic Factors ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma

Survival after pulmonary metastasectomy in soft tissue sarcoma: Prognostic factors in 214 patients

1995 ◽  
Vol 66 (6) ◽  
pp. 561-568 ◽  
Author(s):  
Peter F M Choong ◽  
Douglas J Pritchard ◽  
Michael G Rock ◽  
Franklin H Sim ◽  
Frank J Frassica
Keyword(s):  
Prognostic Factors ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Pulmonary Metastasectomy

Prognostic Factors and Oncological Outcomes of 122 Head and Neck Soft Tissue Sarcoma Patients Treated at a Single Institution

2014 ◽  
Vol 22 (1) ◽  
pp. 248-255 ◽  
Author(s):  
Jin Taek Park ◽  
Jong-Lyel Roh ◽  
Seon-Ok Kim ◽  
Kyung-Ja Cho ◽  
Seung-Ho Choi ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Head And Neck ◽  
Single Institution ◽  
Oncological Outcomes

scholarly journals Multivariate analysis for clinical prognostic factors in 163 patients with soft tissue sarcoma

Cancer ◽  
1988 ◽  
Vol 62 (7) ◽  
pp. 1444-1450 ◽  
Author(s):  
Takafumi Ueda ◽  
Katsuyuki Aozasa ◽  
Masahiko Tsujimoto ◽  
Hideki Hamada ◽  
Hideki Hayashi ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Prognostic Factors ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma

Outcome and prognostic factors in soft tissue sarcoma in the adult

1993 ◽  
Vol 27 (5) ◽  
pp. 1091-1099 ◽  
Author(s):  
J. Levay ◽  
B. O'sullivan ◽  
C. Catton ◽  
R. Bell ◽  
V. Fornasier ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma

Prognostic Factors for Children and Adolescents With Surgically Resected Nonrhabdomyosarcoma Soft Tissue Sarcoma: An Analysis of 121 Patients Treated at St Jude Children's Research Hospital

1999 ◽  
Vol 17 (12) ◽  
pp. 3697-3705 ◽  
Author(s):  
Sheri L. Spunt ◽  
Catherine A. Poquette ◽  
Yasmeen S. Hurt ◽  
Alvida M. Cain ◽  
Bhaskar N. Rao ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Tumor Size ◽  
Primary Tumor ◽  
Distant Recurrence ◽  
High Grade ◽  
Tumor Site ◽  
Primary Tumor Site ◽  
Positive Surgical Margins

PURPOSE: The rarity and heterogeneity of pediatric nonrhabdomyosarcoma soft tissue sarcoma (NRSTS) has precluded meaningful analysis of prognostic factors associated with surgically resected disease. To define a population of patients at high risk of treatment failure who might benefit from adjuvant therapies, we evaluated the relationship between various clinicopathologic factors and clinical outcome of children and adolescents with resected NRSTS over a 27-year period at our institution. PATIENTS AND METHODS: We analyzed the records of 121 consecutive patients with NRSTS who underwent surgical resection between August 1969 and December 1996. Demographic data, tumor characteristics, treatment, and outcomes were recorded. Univariate and multivariate analyses of prognostic factors for survival, event-free survival (EFS), and local and distant recurrence were performed. RESULTS: At a median follow-up of 9.2 years, 5-year survival and EFS rates for the entire cohort were 89% ± 3% and 77% ± 4%, respectively. In univariate models, positive surgical margins (P = .004), tumor size ≥ 5 cm (P < .001), invasiveness (P = .002), high grade (P = .028), and intra-abdominal primary tumor site (P = .055) adversely affected EFS. All of these factors except invasiveness remained prognostic of EFS and survival in multivariate models. Positive surgical margins (P = .003), intra-abdominal primary tumor site (P = .028), and the omission of radiation therapy (P = .043) predicted local recurrence, whereas tumor size ≥ 5 cm (P < .001), invasiveness (P < .001), and high grade (P = .004) predicted distant recurrence. CONCLUSION: In this largest single-institution analysis of pediatric patients with surgically resected NRSTS, we identified clinicopathologic features predictive of poor outcome. These variables should be prospectively evaluated as risk-adapted therapies are developed.

scholarly journals Prognostic Factors Predictive of Survival and Local Recurrence for Extremity Soft Tissue Sarcoma

1994 ◽  
Vol 219 (2) ◽  
pp. 165-173 ◽  
Author(s):  
Samuel Singer ◽  
Joseph M. Corson ◽  
Rene Gonin ◽  
Brian Labow ◽  
Timothy J. Eberlein
Keyword(s):  
Prognostic Factors ◽  
Soft Tissue ◽  
Local Recurrence ◽  
Soft Tissue Sarcoma ◽  
Extremity Soft Tissue Sarcoma

scholarly journals Prognostic Factors Predictive of Survival for Truncal and Retroperitoneal Soft-Tissue Sarcoma

1995 ◽  
Vol 221 (2) ◽  
pp. 185-195 ◽  
Author(s):  
Samuel Singer ◽  
Joseph M. Corson ◽  
George D. Demetri ◽  
Elizabeth A. Healey ◽  
Karen Marcus ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Retroperitoneal Soft Tissue Sarcoma

scholarly journals One-year mortality in patients with bone and soft tissue sarcomas as an indicator of delay in presentation

2015 ◽  
Vol 97 (6) ◽  
pp. 425-433 ◽  
Author(s):  
R Nandra ◽  
N Hwang ◽  
GS Matharu ◽  
K Reddy ◽  
R Grimer
Keyword(s):  
Prognostic Factors ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Performance Indicator ◽  
Tumour Size ◽  
Soft Tissue Sarcomas ◽  
Mortality Data ◽  
Term Survival ◽  
Duration Of Symptoms ◽  
One Year

Introduction For many cancers, one-year mortality following diagnosis is a reflection of either advanced stage at diagnosis, multiple co-morbidities and/or complications of treatment. One-year mortality has not been reported for soft tissue or bone sarcomas. This study reports 1-year sarcoma mortality data over a 25-year period, investigates prognostic factors and considers whether a delay in presentation affects 1-year mortality. Methods A total of 4,945 newly diagnosed bone sarcoma and soft tissue sarcoma patients were identified from a prospectively maintained, single institution oncology database. Of these, 595 (12%) died within 1 year of diagnosis. Both patient factors and tumour characteristics available at diagnosis were analysed for effect. Results There was significant variation in one-year mortality between different histological subtypes. There has been no significant change in mortality rate during the last 25 years (mean: 11.7%, standard deviation: 2.8 percentage points). Soft tissue sarcoma patients who survived over one year reported a longer duration of symptoms preceding diagnosis than those who died (median: 26 vs 20 weeks, p<0.001). Prognostic factors identified in both bone and soft tissue sarcomas mirrored those for mid to long-term survival, with high tumour stage, large tumour size, metastases at diagnosis and increasing age having the greatest predictive effect. Conclusions One-year mortality in bone and soft tissue sarcoma patients is easy to measure, and could be a proxy for late presentation and therefore a potential performance indicator, similar to other cancers. It is possible to predict the risk of one-year mortality using factors available at diagnosis. Death within one year does not correlate with a long history but is associated with advanced disease at diagnosis.

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