scholarly journals Borna Disease Virus and Psychiatric Disorders: Can Viruses Influence Psychiatric Disorders?

10.5772/25671 ◽  
2011 ◽  
Author(s):  
Sylva Rackova ◽  
Lubos Janu
Keyword(s):  
Psychiatric Disorders ◽  
Disease Virus ◽  
Borna Disease Virus ◽  
Borna Disease

Borna Disease Virus infection in children with psychiatric disorders

Apmis ◽  
2008 ◽  
Vol 116 ◽  
pp. 80-82 ◽  
Author(s):  
RENATO DONFRANCESCO ◽  
PAOLA GREGORI ◽  
ANTONELLA VULCANO ◽  
ELISA CANDELORI ◽  
ROBERTO RONCHETTI ◽  
...  
Keyword(s):  
Virus Infection ◽  
Psychiatric Disorders ◽  
Disease Virus ◽  
Borna Disease Virus ◽  
Borna Disease

No association of Borna disease virus with psychiatric disorders among patients in Northern Kyushu, Japan

2000 ◽  
Vol 61 (3) ◽  
pp. 336-340 ◽  
Author(s):  
Katsuro Tsuji ◽  
Koji Toyomasu ◽  
Yoshihiro Imamura ◽  
Hisao Maeda ◽  
Tetsuya Toyoda
Keyword(s):  
Psychiatric Disorders ◽  
Disease Virus ◽  
Borna Disease Virus ◽  
Borna Disease

Borna disease virus and psychiatric disorders

2002 ◽  
Vol 57 (2-3) ◽  
pp. 303-305 ◽  
Author(s):  
Pierrick Lebain ◽  
Astrid Vabret ◽  
Perrine Brazo ◽  
Benoı̂t Chabot ◽  
François Freymuth ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Disease Virus ◽  
Borna Disease Virus ◽  
Borna Disease

scholarly journals Detection of Borna Disease Virus-Reactive Antibodies from Patients with Psychiatric Disorders and from Horses by Electrochemiluminescence Immunoassay

1999 ◽  
Vol 6 (5) ◽  
pp. 696-700 ◽  
Author(s):  
Kazunari Yamaguchi ◽  
Takashi Sawada ◽  
Tohru Naraki ◽  
Ruriko Igata-Yi ◽  
Hiroshi Shiraki ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Mood Disorders ◽  
Disease Virus ◽  
Blood Donors ◽  
Systemic Lupus Erythematosis ◽  
Specific Method ◽  
Borna Disease Virus ◽  
Feral Horses ◽  
Electrochemiluminescence Immunoassay ◽  
Borna Disease

ABSTRACT The prevalence of Borna disease virus (BDV)-specific antibodies among patients with psychiatric disorders and healthy individuals has varied in several reports using several different serological assay methods. A reliable and specific method for anti-BDV antibodies needs to be developed to clarify the pathological significance of BDV infections in humans. We developed a new electrochemiluminescence immunoassay (ECLIA) for the antibody to BDV that uses two recombinant proteins of BDV, p40 and p24 (full length). Using this ECLIA, we examined 3,476 serum samples from humans with various diseases and 917 sera from blood donors in Japan for the presence of anti-BDV antibodies. By ECLIA, 26 (3.08%) of 845 schizophrenia patients and 9 (3.59%) of 251 patients with mood disorders were seropositive for BDV. Among 323 patients with other psychiatric diseases, 114 with neurological diseases, 75 with chronic fatigue syndrome, 85 human immunodeficiency virus-infected patients, 50 with autoimmune diseases including rheumatoid arthritis and systemic lupus erythematosis and 17 with leprosy, there was no positive case except one case each with alcohol addiction, AIDS, and dementia. Although 19 (1.36%) of 1,393 patients with various ocular diseases, 10 (1.09%) of 917 blood donors, and 3 (4.55%) of 66 multitransfused patients were seropositive for BDV-specific antigen, high levels of seroprevalence in schizophrenia patients and young patients (16 to 59 years old) with mood disorders were statistically significant. The immunoreactivity of seropositive sera could be verified for specificity by blocking with soluble p40 and/or p24 recombinant protein. Anti-p24 antibody was more frequent than p40 antibody in most cases, and in some psychotic patients antibody profiles showed only p40 antibody. Although serum positive for both p40 and p24 antibodies was not found in this study, the p40 ECLIA count in schizophrenia patients was higher than that of blood donors. Furthermore, we examined 90 sera from Japanese feral horses. Antibody profiles of control human samples are similar to that of naturally BDV-infected feral horses. We concluded that BDV infection was associated in some way with psychiatric disorders.

scholarly journals Pathogenesis of Borna Disease Virus: Granulocyte Fractions of Psychiatric Patients Harbor Infectious Virus in the Absence of Antiviral Antibodies

1999 ◽  
Vol 73 (8) ◽  
pp. 6251-6256 ◽  
Author(s):  
Oliver Planz ◽  
Christine Rentzsch ◽  
Anil Batra ◽  
Arvind Batra ◽  
Tanja Winkler ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Psychiatric Disorders ◽  
Disease Virus ◽  
Infectious Virus ◽  
Psychiatric Patients ◽  
Borna Disease Virus ◽  
Human Virus ◽  
Close Relationship ◽  
Autopsy Brain Tissue ◽  
Borna Disease

ABSTRACT Borna disease virus (BDV) causes acute and persistent infections in various vertebrates. During recent years, BDV-specific serum antibodies, BDV antigen, and BDV-specific nucleic acid were found in humans suffering from psychiatric disorders. Furthermore, viral antigen was detected in human autopsy brain tissue by immunohistochemical staining. Whether BDV infection can be associated with psychiatric disorders is still a matter of debate; no direct evidence has ever been presented. In the present study we report on (i) the detection of BDV-specific nucleic acid in human granulocyte cell fraction from three different psychiatric patients and (ii) the isolation of infectious BDV from these cells obtained from a patient with multiple psychiatric disorders. In leukocyte preparations other than granulocytes, either no BDV RNA was detected or positive PCR results were obtained only if there was at least 20% contamination with granulocytes. Parts of the antigenome of the isolated virus were sequenced, demonstrating the close relationship to the prototype BDV strains (He/80 and strain V) as well as to other human virus sequences. Our data provide strong evidence that cells in the granulocyte fraction represent the major if not the sole cell type harboring BDV-specific nucleic acid in human blood and contain infectious virus. In contrast to most other reports of putative human isolates, where sequences are virtually identical to those of the established laboratory strains, this isolate shows divergence in the region previously defined as variable in BDV from naturally infected animals.

Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders

Science ◽  
1985 ◽  
Vol 228 (4700) ◽  
pp. 755-756 ◽  
Author(s):  
R Rott ◽  
S Herzog ◽  
B Fleischer ◽  
A Winokur ◽  
J Amsterdam ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Disease Virus ◽  
Serum Antibodies ◽  
Borna Disease Virus ◽  
Borna Disease
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