scholarly journals New Challenges for Old Diseases: The Impact of -Omics Technologies in the Understanding of Allergic Diseases

10.5772/25636 ◽  
2012 ◽  
Author(s):  
Blanca Crdaba ◽  
Miriam Aguerri ◽  
David Calzada ◽  
Carlos Lahoz
Keyword(s):  
Allergic Diseases ◽  
Omics Technologies ◽  
New Challenges ◽  
The Impact

PODC 2020 Review

2021 ◽  
Vol 51 (4) ◽  
pp. 75-81
Author(s):  
Ahad Mirza Baig ◽  
Alkida Balliu ◽  
Peter Davies ◽  
Michal Dory
Keyword(s):  
Machine Learning ◽  
Distributed Computing ◽  
Keynote Speaker ◽  
Lively Discussion ◽  
Theoretical Understanding ◽  
New Directions ◽  
New Ideas ◽  
New Challenges ◽  
The Impact ◽  
Distributed Machine Learning

Rachid Guerraoui was the rst keynote speaker, and he got things o to a great start by discussing the broad relevance of the research done in our community relative to both industry and academia. He rst argued that, in some sense, the fact that distributed computing is so pervasive nowadays could end up sti ing progress in our community by inducing people to work on marginal problems, and becoming isolated. His rst suggestion was to try to understand and incorporate new ideas coming from applied elds into our research, and argued that this has been historically very successful. He illustrated this point via the distributed payment problem, which appears in the context of blockchains, in particular Bitcoin, but then turned out to be very theoretically interesting; furthermore, the theoretical understanding of the problem inspired new practical protocols. He then went further to discuss new directions in distributed computing, such as the COVID tracing problem, and new challenges in Byzantine-resilient distributed machine learning. Another source of innovation Rachid suggested was hardware innovations, which he illustrated with work studying the impact of RDMA-based primitives on fundamental problems in distributed computing. The talk concluded with a very lively discussion.

The Impact of COVID-19: Democracy in the Time of a Pandemic

Social Change ◽  
2021 ◽  
Vol 51 (4) ◽  
pp. 475-482
Author(s):  
Zoya Hasan
Keyword(s):  
Social Sciences ◽  
Human Rights ◽  
Social Development ◽  
Health Crisis ◽  
Domain Experts ◽  
Sharp Focus ◽  
The World ◽  
Democratic Rights ◽  
New Challenges ◽  
The Impact

The recent spread of the delta variant of the COVID-19 pandemic in many countries, though uneven, has once again set alarm bells ringing throughout the world. Nearly two years have passed since the onset of this pandemic: vaccines have been developed and vaccination is underway, but the end of the campaign against the pandemic is nowhere in sight. This drive has merely attempted to adjust and readjust, with or without success, to the various fresh challenges that have kept emerging from time to time. The pandemic’s persistence and its handling by the governments both have had implications for citizens’/peoples’ rights as well as for the systems which were in place before the pandemic. In this symposium domain experts investigate, with a sharp focus on India, the interface between the COVID-19 pandemic and democracy, health, education and social sciences. These contributions are notable for their nuanced and insightful examination of the impact of the pandemic on crucial social development issues with special attention to the exacerbated plight of society’s marginalised sections. In India, as in several other countries, the COVID-19 pandemic has affected democracy. The health crisis came at a moment when India was already experiencing democratic backsliding. The pandemic came in handy in imposing greater restrictions on democratic rights, public discussion and political opposition. This note provides an analysis and commentary on how the government’s response to the COVID-19 pandemic impacted governance, at times undermining human rights and democratic processes, and posing a range of new challenges to democracy.

EXPERIENCE OF DEVELOPED COUNTRIES OF THE WORLD ON REGULATION OF SPORTS AND HEALTH SPHERE AND PROMOTION OF ITS DEVELOPMENT

2021 ◽  
Vol 9 (1) ◽  
pp. 91-100
Author(s):  
Serhii Tsymbaliuk
Keyword(s):  
Comparative Analysis ◽  
Developed Countries ◽  
Scientific Basis ◽  
Organizational Models ◽  
Economic Role ◽  
The World ◽  
New Challenges ◽  
Developed World ◽  
The Impact

The purpose of the article is to study the experience of developed countries in the regulation of sports and health in order to stimulate its development and adaptation to new challenges and threats. In the course of the research the methods of theoretical and comparative analysis were used to reveal the peculiarities of the American and European models of sports and health man-agement; statistical and graphical - to determine the economic role and trends in the sports and health industry in the world, the impact of the pandemic on income from sports. The article develops organizational and economic approaches to intensify the development of sports and recreation. Certain features of organizational models of management, sports legislation, financ-ing, possible tools to stimulate the development of sports and health in the developed world form a scientific basis for substantiating ways to intensify this area.

scholarly journals Differential uptake of three clinically relevant allergens by human plasmacytoid dendritic cells

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Noelle Zurmühl ◽  
Anna Schmitt ◽  
Ulrike Formentini ◽  
Johannes Weiss ◽  
Heike Appel ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Healthy Subjects ◽  
Time Course ◽  
In Vitro Study ◽  
Allergic Diseases ◽  
Plasmacytoid Dendritic Cells ◽  
Antigen Uptake ◽  
Der P 1 ◽  
The Impact

Abstract Background Human plasmacytoid dendritic cells (pDC) have a dual role as interferon-producing and antigen-presenting cells. Their relevance for allergic diseases is controversial. and the impact of pDC on allergic immune responses is poorly understood. Methods This in vitro study on human pDC isolated from peripheral blood was designed to compare side by side the uptake of three clinically relevant representative allergens: fluorochrome-labeled house dust mite Der p 1, Bee venom extract from Apis mellifera (Api) and the food allergen OVA analyzed flow cytometry and confocal microscopy. Results We found that the internalization and its regulation by TLR9 ligation was significantly different between allergens in terms of time course and strength of uptake. Api and OVA uptake in pDC of healthy subjects was faster and reached higher levels than Der p 1 uptake. CpG ODN 2006 suppressed OVA uptake and to a lesser extent Der p 1, while Api internalization was not affected. All allergens colocalized with LAMP1 and EEA1, with Api being internalized particularly fast and reaching highest intracellular levels in pDC. Of note, we could not determine any specific differences in antigen uptake in allergic compared with healthy subjects. Conclusions To our knowledge this is the first study that directly compares uptake regulation of clinically relevant inhalative, injective and food allergens in pDC. Our findings may help to explain differences in the onset and severity of allergic reactions as well as in the efficiency of AIT.

scholarly journals Intestinal Microbiota and Allergy. Probiotics and Prebiotics in Prevention and Treatment of Allergic Diseases

2019 ◽  
Vol 16 (1) ◽  
pp. 7-18 ◽  
Author(s):  
Svetlana G. Makarova ◽  
Leyla S. Namazova-Baranova ◽  
Oksana A. Ereshko ◽  
Dmitry S. Yasakov ◽  
Pavel E. Sadchikov
Keyword(s):  
Immune Response ◽  
Clinical Trials ◽  
Intestinal Microbiota ◽  
Practical Interest ◽  
Allergic Diseases ◽  
Evidence Based ◽  
Prevention And Treatment ◽  
The Impact ◽  
Positive Results ◽  
Intestinal Microbiocenosis

Intestinal microbiota is the factor that identifies considerably the human health. The impact of the microbial factor on a child begins long before his birth. Children have certain features in forming of immune response and intestinal microbiocenosis even before birth. Decline in diversity of intestinal microbiota is common in children with allergic disease even during first months of life, before allergic pathology development. Capabilities for microbiota development adjustment are sufficiently restricted. However it is clinically proven that early (within the first hours of life) breastfeeding attachment, breastfeeding itself within at least first 6 months of life, the use of prebiotics in milk formulas as well as the use of probiotics can give positive results on allergy management. In this review we present results of recent metaanalyses and consensus papers of international medical communities about use of probiotics and prebiotics in prevention and treatment of allergic diseases. Despite great scientific and practical interest to this topic, authors of metaanalyses bring our attention to the lack of evidence-based clinical trials.

scholarly journals Cybersecurity in the EU and Member States: Genesis and Issues of its Enhancing

2019 ◽  
pp. 57-69
Author(s):  
Viktor Boiko ◽  
Mykola Vasylenko ◽  
Serhii Kukharenko
Keyword(s):  
Systematic Approach ◽  
New Technologies ◽  
Member States ◽  
Eu Member States ◽  
Eu Legislation ◽  
Regulatory Instruments ◽  
New Challenges ◽  
Ict Development ◽  
The Impact ◽  
The Eu

The article deals with the issues of establishing cybersecurity in the EU and its member-states at the legislative level as viewed from the point of a systematic approach. The authors identified problematic aspects of improving cybersecurity quality and conditions. They analyzed the impact of the EU member states legislation on cy-bersecurity. The article as well considers the process of ICT development and pre-sents the ways of creating new challenges by means of new technologies. Key words: cybersecurity, cyber resilience, regulatory instruments, EU legislation, innovations.

La orientación al dato, nuevos desafíos

Tábula ◽  
2021 ◽  
Author(s):  
Miguel Ángel Amutio Gómez
Keyword(s):  
European Union ◽  
Digital Transformation ◽  
Data Driven ◽  
The European Union ◽  
Data Preservation ◽  
The Future ◽  
Data Driven Approach ◽  
New Challenges ◽  
The Impact

La orientación al dato en el contexto de la transformación digital lleva aparejada la aparición de nuevas regulaciones, dinámicas de gobernanza y roles, y servicios, junto con las correspondientes prácticas, instrumentos y estándares. A la vez se suscitan retos en relación con la ciberseguridad y la preservación de los datos. En este artículo se exponen la transformación digital y la orientación al dato, la proyección de lo anterior en la administración digital, el contexto de la Unión Europea, trayectoria y su orientación, aspectos de la interoperabilidad, ciberseguridad y preservación de los datos, cuestiones de gobernanza y roles en la orientación al dato y, finalmente, unas conclusiones. The data-driven approach in the context of digital transformation entails the appearance of new regulations, governance dynamics and roles, and services, together with the corresponding practices, instruments and standards. At the same time new challenges appear in relation to cybersecurity and data preservation. This article presents the digital transformation and data-driven approach, the impact in digital administration, the context of the European Union, trajectory and orientation towards the future, along with aspects of interoperability, cybersecurity and data preservation, as well as issues of governance and roles in data orientation and finally some conclusions.

The Impact on Employment

2017 ◽  
Author(s):  
Gabor Forgacs ◽  
Sara Dolnicar
Keyword(s):  
Just In Time ◽  
Full Time ◽  
Employment Opportunities ◽  
Contingent Employment ◽  
New Challenges ◽  
Tourism And Hospitality ◽  
Full Time Employment ◽  
The Impact ◽  
Additional Income

Contingent (just-in-time, or gig) employment is on the rise in tourism and hospitality. People in contingent employment are not offered long-term contracts, but are called upon when needed. This chapter explores whether peer-to-peer accommodation networks are part of the problem or part of the solution. They create new challenges by increasing the competitive pressure on the established commercial sector, which leads to a reduction in jobs and a conversion of full-time to contingent employment. But they also offer new employment opportunities: without entry barriers, people can earn additional income by renting out spare space, and other opportunities – especially for a workforce trained in hospitality – are emerging as listing managers for hosts. These jobs may be particularly suitable to people traditionally struggling with full-time employment arrangements.

International processes in Latin America: the legacy of the Comintern and new challenges

2021 ◽  
Vol 31 (1) ◽  
pp. 106-125
Author(s):  
Anton Andreev ◽  
◽  
Daria Pravdiuk
Keyword(s):  
Foreign Policy ◽  
Latin America ◽  
21St Century ◽  
Theory And Practice ◽  
The Political ◽  
The Third ◽  
Archival Documents ◽  
History Of ◽  
New Challenges ◽  
The Impact

The activities of the Third (Communist) International left a noticeable mark on the political history of Latin America. His ideological, organizational legacy remains a factor in shaping the theory and practice of contemporary leftist governments in the region. This article examines the impact of the legacy of the Comintern on international processes in Latin America, the development of integration projects, foreign policy projects of the left forces of the region. On the basis of archival documents, media materials, documents of parties and governments, the authors show which of the foreign policy guidelines of the Comintern are relevant for the region in the 21st century.

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