scholarly journals Molecular Mechanisms Involving Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma (HNSCC) – Roles of Hypoxic Microenvironment and Cancer Stem Cell

10.5772/25574 ◽  
2012 ◽  
Author(s):  
Xiaoming Li ◽  
Qingjia Sun ◽  
Yupeng She
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Molecular Mechanisms ◽  
Neck Squamous Cell Carcinoma ◽  
Therapeutic Resistance

O59. Cancer stem cell induced angiogenesis in head and neck squamous cell carcinoma

Oral Oncology ◽  
2011 ◽  
Vol 47 ◽  
pp. S49
Author(s):  
R.M. Zimmerer ◽  
A. Kampmann ◽  
F. Tavassol ◽  
H. Kokemüller ◽  
N.-C. Gellrich ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma

Enrichment of Cells with Cancer Stem Cell-Like Markers in Relapses of Chemoresistant Patients with Locally Advanced Head and Neck Squamous Cell Carcinoma

Oncology ◽  
2016 ◽  
Vol 90 (5) ◽  
pp. 267-272 ◽  
Author(s):  
Juan J. Grau ◽  
Ricard Mesía ◽  
Maria de la Iglesia-Vicente ◽  
Estrelania S. Williams ◽  
Miren Taberna ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Locally Advanced ◽  
Neck Squamous Cell Carcinoma ◽  
Advanced Head

scholarly journals Effectiveness of Hypoxia-Induced Accumulation of Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma

2020 ◽  
Vol 3 (S1) ◽  
pp. 13-23
Author(s):  
Bezerra MAS ◽  
◽  
Ferreira LAM ◽  
Kawasaki-Oyama RS ◽  
Nascimento MCA ◽  
...  
Keyword(s):  
Stem Cells ◽  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Cell Accumulation

INTRODUCTION: The small number of cancer stem cells, which correspond to only 0.01% - 0.1% of total tumor cells, has been the biggest obstacle in understanding their biology and role in the origin and maintenance of tumors, their metastatic and recurrence potentials, and resistance to radio-chemotherapy. Therefore, promoting its accumulation will enable further studies and future advances in the diagnosis and treatment of head and neck cancer squamous cell carcinoma. OBJECTIVE: To induce cancer stem cell accumulation in primary cell cultures of head and neck squamous cell carcinoma using a hypoxia chamber. METHODS: Head and neck squamous cell carcinoma samples were cultured and subjected to hypoxia. Oxygen deprivation aimed to induce cancer stem cell accumulation. RESULTS: Immediately after hypoxia, the percentage of O2-deprived cancer stem cells increased 2-fold as compared to control. Surprisingly, new phenotyping performed 45 days after hypoxia showed a 9-fold increase in cancer stem cell percentage in cells that suffered hypoxia. Hypoxic cells showed an increase in spheroid formation when compared to control cells, as well as enhanced abilities in invasion and migration. CONCLUSION: Hypoxia was efficient in cancer stem cell accumulation. As cancer stem cells are a small number of cells within the tumor, promoting their accumulation will enable further studies and future advances in the diagnosis and treatment of head and neck cancer.

scholarly journals CD200: Association with cancer stem cell features and response to chemoradiation in head and neck squamous cell carcinoma

Head & Neck ◽  
2014 ◽  
Vol 37 (3) ◽  
pp. 327-335 ◽  
Author(s):  
Yuh-Seog Jung ◽  
Paola D. Vermeer ◽  
Daniel W. Vermeer ◽  
Sang-Jin Lee ◽  
Ah Ra Goh ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma
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