scholarly journals Relationship Between Natriuretic Peptides and Hemodynamic Parameters Following Heart Surgery in Infancy

10.5772/25535 ◽  
2012 ◽  
Author(s):  
Andrea Szkely ◽  
Tams Breuer ◽  
Bla Merkely
Keyword(s):  
Natriuretic Peptides ◽  
Heart Surgery ◽  
Hemodynamic Parameters

Levels of natriuretic peptides during paediatric open heart surgery

2004 ◽  
Vol 21 (Supplement 33) ◽  
pp. 20
Author(s):  
A. Székely ◽  
L. Seres ◽  
E. Székely ◽  
E. Sápi ◽  
M. Toth ◽  
...  
Keyword(s):  
Natriuretic Peptides ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart

Use of warm priming solution in open heart surgery: its effects on hemodynamics and acute inflammation

Perfusion ◽  
2008 ◽  
Vol 23 (2) ◽  
pp. 89-94 ◽  
Author(s):  
M Buyukates ◽  
S Acikgoz ◽  
O Kandemir ◽  
E Aktunc ◽  
E Ceylan ◽  
...  
Keyword(s):  
Inflammatory Markers ◽  
Heart Surgery ◽  
Artery Bypass ◽  
Open Heart Surgery ◽  
Organ Damage ◽  
Significant Rise ◽  
Open Heart ◽  
Hemodynamic Parameters ◽  
Ephedrine Hydrochloride ◽  
Factor Α

Cardiac surgery causes an acute inflammatory response and organ damage. In this study, for the first time in the literature, we compared the effects of priming solutions at 20°C and 36°C on acute inflammatory markers and hemodynamic parameters. Forty patients were recruited and randomized into two groups, each consisting of 20 participants who underwent elective coronary artery bypass grafting operation. Groups were primed with the same solution at different temperatures. Hemodynamic parameters were recorded. Blood samples were drawn pre-operatively and at the 15th and 60th minutes of aortic cross-clamping and the 24th hour following surgery. Serum pre-albumin, α-1 antitrypsin, and tumor necrosis factor-α levels were determined. The groups were compared statistically. Both of the groups were comparable for mean aortic cross-clamping time and mean time for cardiopulmonary bypass. Mean blood pressure value was significantly lower and the mean amount of ephedrine hydrochloride used was significantly higher in the cold priming group. Spontaneous beating of the heart after removal of aortic cross-clamp significantly was more frequent in the warm priming group. A significant rise was observed in systemic inflammatory markers in the cold priming group. In our study, the lesser amount of ephedrine hydrochloride used and the higher frequency of spontneous beating of the heart in the warm priming group may be considered as improvements in hemodynamic status. Use of warm priming solution also induced a significant improvement in the acute inflammatory markers. We recommend the use of warm priming solution in open heart surgery.

The implications of Milrinone Lactate in the Postoperative Clinical Management of Surgical Interventions for Congenital Heart Malformations in Children

2017 ◽  
Vol 68 (11) ◽  
pp. 2658-2661
Author(s):  
Mariana Anisoara (Ciorba) Puiac ◽  
Horatiu Suciu ◽  
Marius Ilie Ciorba ◽  
Mihaela Maria Opris ◽  
Hussam Al Hussein ◽  
...  
Keyword(s):  
Cardiac Output ◽  
Congenital Heart ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Hemodynamic Parameters ◽  
Low Cardiac Output Syndrome ◽  
Low Cardiac Output ◽  
Congenital Heart Malformations ◽  
Heart Malformations

The purpose of the study was to prove to efficacy of Milrinone in the management of open heart surgery in children with congenital heart malformations, the link between Milrinone efficacy and the prevention of low cardiac output syndrome and Milrinone side effects. We conducted a retrospective study on a group of 24 patients, admitted to the Tg Mures Emergency Institute for Cardiovascular Diseases and Transplant, between August 2016 and February 2017. Milrinone was administered to children that underwent open heart surgery for different congenital heart malformations, using doses between 0.25 and 0.75 mcg per kg bodyweight, in continuous intravenous drip, before de-clamping of the Aorta, the procedures being conducted in extracorporeal circulation. We recorded demographic data, biological parameters of renal function, myocardial function and hemodynamic parameters, before and after surgery. The administration of Milrinone determined a reduction of incidence of low cardiac output syndrome, registering only 4 deaths, the survival rate being 83.33%, 13 cases presenting complications. Postoperatively we registered a significant improvement of the mean heart rate. Milrinone proved efficient in the re-establishment of hemodynamic parameters in patients with this type of clinical manifestations. Using Milrinone in children that undergo open heart surgery determines a decrease in incidence of low cardiac output syndrome, its� presence in the pharma market being necessary.

Safety and utility of modified ultrafiltration in pediatric cardiac surgery

Perfusion ◽  
2021 ◽  
pp. 026765912110436
Author(s):  
David A Palanzo ◽  
Robert K Wise ◽  
Karl R Woitas ◽  
Akif Ündar ◽  
Joseph B Clark ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Heart Surgery ◽  
Congenital Heart Surgery ◽  
Hemodynamic Parameters ◽  
Circulating Blood Volume ◽  
Venous Cannula ◽  
Transfusion Requirements ◽  
Total Body ◽  
Aortic Cannula

Introduction: Modified ultrafiltration (MUF) is employed at the termination of cardiopulmonary bypass (CPB) in pediatric and neonatal patients undergoing congenital heart surgery to reduce the accumulation of total body water thus increasing the concentration of red blood cells and the other formed elements in the circulation. Modified ultrafiltration has been reported to remove circulating pro-inflammatory mediators that result in systemic inflammatory response syndrome (SIRS) postoperatively. Methods: Four hundred patients undergoing cardiac surgery requiring cardiopulmonary bypass and weighing less than or equal to 12 kg were retrospectively evaluated for the effectiveness of MUF. After the termination of CPB, blood was withdrawn through the aortic cannula and passed through a hemoconcentrator attached to the blood cardioplegia set and returned to the patient through the venous cannula. The entire CPB circuit volume in addition to the patient’s circulating blood volume were concentrated until the hematocrit value displayed on the CDI cuvette within the MUF circuit reached 45% or there was no more volume to safely remove. At the same time a full unit of FFP can be infused as water is being removed, thus maintaining euvolemia. Results: MUF was performed in all 400 patients with no MUF-related complications. Following the conclusion of MUF, anecdotal observations included improved surgical hemostasis, improved hemodynamic parameters, decreased transfusion requirements, and decreased ventilator times. Conclusions: Complete MUF enables the clinician to safely raise the post-CPB hematocrit to at least 40% while potentially removing mediators that could result in SIRS. In addition a full unit of FFP can be administered while maintaining euvolemia.

Detection of atrial natriuretic peptides (ANP) in rat atria by immunogold-silver staining (IGSS)

1994 ◽  
Vol 52 ◽  
pp. 304-305
Author(s):  
Robyn Rufner ◽  
Gerhard W. Hacker ◽  
Michele Forte ◽  
Nancyleigh E. Carson ◽  
Cristina Xenachis ◽  
...  
Keyword(s):  
Natriuretic Peptides ◽  
Silver Staining ◽  
Sodium Thiosulfate ◽  
Atrial Natriuretic Peptides ◽  
Paraffin Sections ◽  
Glass Slides ◽  
Metallic Salts ◽  
Wistar Kyoto ◽  
Right Atria

The use of immunogold-silver staining (IGSS) to enhance label penetration and Localization for immunocytochemistry or in situ hybridization utilizing a variety of metallic salts has been documented. In this morphological study, the effects of silver acetate, silver lactate and silver nitrate were evaluated for immunogold-labeling of a trial natriuretic peptides (ANP) in rat right atria.Eight Wistar Kyoto retired breeders were sedated with pentobarbital, perfused with either 4% paraformaldehyde (LM) or Karnovsky's fixative (EM), and right atria were dissected, processed, embedded in paraffin or epon, respectively and sectioned according to conventional methods. For light microscopy, an indirect IGSS method according to Hacker (3) was performed. Paraffin sections on glass slides were washed in ddH2O, immersed in Lugol's iodine, washed in ddH2O and treated with 2.5% aqueous sodium thiosulfate for 20 sec. After additional washes in ddH2O and TBS-0.1% fish gelatin, 10% normal goat serum (PBS with 1% BSA) was applied for 20 min before an overnight incubation at 4°C with a polyclonal α-ANP primary antibody (Peninsula Labs, 1:1000 in TBS/BSA).

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