scholarly journals Modulation of One-Carbon Metabolism by B Vitamins: Implications for Transformation and Progression of Prostate Cancer

10.5772/25307 ◽  
2011 ◽  
Author(s):  
Glenn Tisman
Keyword(s):  
Prostate Cancer ◽  
Carbon Metabolism ◽  
B Vitamins ◽  
One Carbon Metabolism

scholarly journals One-Carbon Metabolism and Prostate Cancer Risk: Prospective Investigation of Seven Circulating B Vitamins and Metabolites

2009 ◽  
Vol 18 (5) ◽  
pp. 1538-1543 ◽  
Author(s):  
Mattias Johansson ◽  
Bethany Van Guelpen ◽  
Stein Emil Vollset ◽  
Johan Hultdin ◽  
Anders Bergh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Carbon Metabolism ◽  
Prostate Cancer Risk ◽  
B Vitamins ◽  
One Carbon Metabolism ◽  
Prospective Investigation

scholarly journals Supplemental one‐carbon metabolism related B vitamins and lung cancer risk in the Women's Health Initiative

2020 ◽  
Vol 147 (5) ◽  
pp. 1374-1384 ◽  
Author(s):  
Theodore M. Brasky ◽  
Roberta M. Ray ◽  
Sandi L. Navarro ◽  
Jeannette M. Schenk ◽  
Alison M. Newton ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Women's Health ◽  
Carbon Metabolism ◽  
Lung Cancer Risk ◽  
B Vitamins ◽  
Women's Health Initiative ◽  
Health Initiative ◽  
One Carbon Metabolism ◽  
The Women’S Health Initiative

scholarly journals One-carbon metabolism–related nutrients and prostate cancer survival

2009 ◽  
Vol 90 (3) ◽  
pp. 561-569 ◽  
Author(s):  
Julie L Kasperzyk ◽  
Katja Fall ◽  
Lorelei A Mucci ◽  
Niclas Håkansson ◽  
Alicja Wolk ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Carbon Metabolism ◽  
Cancer Survival ◽  
One Carbon Metabolism

The role of one-carbon metabolism and homocysteine in Parkinson’s disease onset, pathology and mechanisms

2019 ◽  
Vol 32 (2) ◽  
pp. 218-230 ◽  
Author(s):  
Lauren K. Murray ◽  
Nafisa M. Jadavji
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Carbon Metabolism ◽  
Animal Studies ◽  
B Vitamins ◽  
Present Review ◽  
Increased Risk ◽  
One Carbon Metabolism ◽  
B Vitamin

AbstractParkinson’s disease (PD) is the second most common neurodegenerative disorder. It is characterised by the progressive degeneration of dopaminergic (DA) neurons. The cause of degeneration is not well understood; however, both genetics and environmental factors, such as nutrition, have been implicated in the disease process. Deficiencies in one-carbon metabolism in particular have been associated with increased risk for PD onset and progression, though the precise relationship is unclear. The aim of the present review is to determine the role of one-carbon metabolism and elevated levels of homocysteine in PD onset and pathology and to identify potential mechanisms involved. A search of PubMed, Google Scholar and Web of Science was undertaken to identify relevant human and animal studies. Case–control, prospective cohort studies, meta-analyses and non-randomised trials were included in the present review. The results from human studies indicate that polymorphisms in one-carbon metabolism may increase risk for PD development. There is an unclear role for dietary B-vitamin intake on PD onset and progression. However, dietary supplementation with B-vitamins may be beneficial for PD-affected individuals, particularly those on l-DOPA (levodopa or l-3,4-dihydroxyphenylalanine) treatment. Additionally, one-carbon metabolism generates methyl groups, and methylation capacity in PD-affected individuals is reduced. This reduced capacity has an impact on expression of disease-specific genes that may be involved in PD progression. During B-vitamin deficiency, animal studies report increased vulnerability of DA cells through increased oxidative stress and altered methylation. Nutrition, especially folates and related B-vitamins, may contribute to the onset and progression of PD by making the brain more vulnerable to damage; however, further investigation is required.

Abstract B122: Multi‐SNP analysis of one‐carbon metabolism genes and prostate cancer outcomes

2010 ◽  
Author(s):  
Charnita M. Zeigler‐Johnson ◽  
Bao‐Li Chang ◽  
Saarene Panossian ◽  
Elaine Spangler ◽  
S. Bruce Malkowicz ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Carbon Metabolism ◽  
Snp Analysis ◽  
Cancer Outcomes ◽  
One Carbon Metabolism

scholarly journals Long-Term, Supplemental, One-Carbon Metabolism–Related Vitamin B Use in Relation to Lung Cancer Risk in the Vitamins and Lifestyle (VITAL) Cohort

2017 ◽  
Vol 35 (30) ◽  
pp. 3440-3448 ◽  
Author(s):  
Theodore M. Brasky ◽  
Emily White ◽  
Chi-Ling Chen
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Carbon Metabolism ◽  
Lung Cancer Risk ◽  
Hazard Ratio ◽  
B Vitamins ◽  
Vitamin B ◽  
Supplement Use ◽  
One Carbon Metabolism

Purpose Inconsistent findings have been reported of a link between the use of one-carbon metabolism–related B vitamins and lung cancer risk. Because of the high prevalence of supplemental vitamin B use, any possible increased association warrants further investigation. We examined the association between long-term use of supplemental B vitamins on the one-carbon metabolism pathway and lung cancer risk in the Vitamins and Lifestyle (VITAL) cohort, which was designed specifically to look at supplement use relative to cancer risk. Methods A total of 77,118 participants of the VITAL cohort, 50 to 76 years of age, were recruited between October 2000 and December 2002 and included in this analysis. Incident, primary, invasive lung cancers (n = 808) were ascertained by prospectively linking the participants to a population-based cancer registry. The 10-year average daily dose from individual and multivitamin supplements were the exposures of primary interest. Results Use of supplemental vitamins B6, folate, and B12 was not associated with lung cancer risk among women. In contrast, use of vitamin B6 and B12 from individual supplement sources, but not from multivitamins, was associated with a 30% to 40% increase in lung cancer risk among men. When the 10-year average supplement dose was evaluated, there was an almost two-fold increase in lung cancer risk among men in the highest categories of vitamin B6 (> 20 mg/d; hazard ratio, 1.82; 95% CI, 1.25 to 2.65) and B12 (> 55µg/d; hazard ratio, 1.98; 95% CI, 1.32 to 2.97) compared with nonusers. For vitamin B6 and B12, the risk was even higher among men who were smoking at baseline. In addition, the B6 and B12 associations were apparent in all histologic types except adenocarcinoma, which is the type less related to smoking. Conclusion This sex- and source-specific association provides further evidence that vitamin B supplements are not chemopreventive for lung cancer and may be harmful.

Dietary factors of one-carbon metabolism and prostate cancer risk

2006 ◽  
Vol 84 (4) ◽  
pp. 929-935 ◽  
Author(s):  
Stephanie J Weinstein ◽  
Rachael Stolzenberg-Solomon ◽  
Pirjo Pietinen ◽  
Philip R Taylor ◽  
Jarmo Virtamo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Carbon Metabolism ◽  
Prostate Cancer Risk ◽  
Dietary Factors ◽  
One Carbon Metabolism

scholarly journals TMEFF2 and SARDH cooperate to modulate one-carbon metabolism and invasion of prostate cancer cells

The Prostate ◽  
2013 ◽  
Vol 73 (14) ◽  
pp. 1561-1575 ◽  
Author(s):  
Thomas Green ◽  
Xiaofei Chen ◽  
Stephen Ryan ◽  
Adam S. Asch ◽  
Maria J. Ruiz-Echevarría
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Carbon Metabolism ◽  
Prostate Cancer Cells ◽  
One Carbon Metabolism
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