scholarly journals Prevention Strategy of Urogenital Infections by Using Lactobacilli with Probiotic Properties

Author(s):  
Liliana Pascual ◽  
Lucila Barberis
Author(s):  
ASHLESHA BHAGWAT ◽  
NANDANWAR Y S ◽  
RAHUL WARKE ◽  
UDAY S ANNAPURE

Objective: The human vagina and gut are known to harbor a wide range of bacteria. Some useful bacteria maintain the vaginal pH around 3–4.5. This acidity of the vagina helps to inhibit pathogenic organisms that cause urogenital infections. The present study involved screening of previously identified Enterococcus strains of human origin for their probiotic physiological properties. Materials and Methods: The strains were screened for their biofilm, antibiofilm, antagonistic, antibiotic resistance, adherence, aggregating, and hydrogen peroxide production abilities. Results: Enterococcus canintestini S26B, Entamoeba dispar S27A, E. dispar S26A, E. dispar S20B, E. canintestini AB2, Enterococcus villorum SB2, and Enterococcus rivorum S22C displayed in vitro probiotic properties. Conclusions: These strains can be used as probiotic candidates and may prove their potential in human or animal feed only after further clinical studies.


2007 ◽  
Vol 2007 ◽  
pp. 1-6 ◽  
Author(s):  
Gabriela Zárate ◽  
Viviana Santos ◽  
María Elena Nader-Macias

Urogenital infections of bacterial origin have a high incidence among the world female population at reproductive age. Lactobacilli, the predominant microorganisms of the healthy vaginal microbiota, have shown a protective effect against the colonization and overgrowth of urogenital pathogens that increased the interest for including them into probiotics products assigned to restore the urogenital balance. In the present work, we determined in a mouse animal model the capability ofLactobacillus paracaseiCRL 1289, a human vaginal strain with probiotic properties, to prevent the vaginal colonization of a uropathogenic strain ofStaphylococcus aureus. Six-week-old female BALB/c mice, synchronized in their estral cycle, were intravaginally inoculated with two doses of109lactobacilli before challenging them with a single dose of105or107CFU ofS. aureus. The vaginal colonization of both microorganisms and the effect on the vaginal structure were determined at 2, 5, and 7 days after pathogen inoculation. Control mice and those challenged only with the pathogen showed an insignificant lactobacilli population, whereas105lactobacilli/mL of vaginal homogenate were recovered at 2 days after challenge from theL. paracaseiCRL 1289 and the probiotic + pathogen groups, decreasing this number on the following days. The treatment withL. paracaseiCRL 1289 decreased significantly the number of staphylococci recovered at 2 and 5 days when mice were challenged only with105CFU of pathogen. The inoculation ofS. aureusproduced a remarkable inflammatory response and structural alterations in the vaginal mucosa that decreases in a significant manner when the mice were protected withL. paracaseiCRL 1289. The results obtained suggest that this particularLactobacillusstrain could prevent the onset of urogenital infections by interfering with the epithelial colonization by uropathogenicS. aureus.


2013 ◽  
Author(s):  
Stephen Buka ◽  
Jasmina Burdzovic ◽  
Elizabeth Kretchman ◽  
Charles Williams ◽  
Paul Florin

2019 ◽  
Vol 07 (01) ◽  
Author(s):  
Rahman MR ◽  
Kabir MS ◽  
Khan ZUM ◽  
Pramanik MK

Author(s):  
N.V. Rudakov ◽  
N.A. Penyevskaya ◽  
D.A. Saveliev ◽  
S.A. Rudakova ◽  
C.V. Shtrek ◽  
...  

Research objective. Differentiation of natural focal areas of Western Siberia by integral incidence rates of tick-borne infectious diseases for determination of the strategy and tactics of their comprehensive prevention. Materials and methods. A retrospective analysis of official statistics for the period 2002-2018 for eight sub-federal units in the context of administrative territories was carried out. The criteria of differentiation were determined by means of three evaluation scales, including long-term mean rates of tick-borne encephalitis, tick-borne borreliosis, and Siberian tick-borne typhus. As a scale gradation tool, we used the number of sample elements between the confidence boundaries of the median. The integral assessment was carried out by the sum of points corresponding to the incidence rates for each of the analyzed infections. Results. The areas of low, medium, above average, high and very high risk of tick-borne infectious diseases were determined. Recommendations on the choice of prevention strategy and tactics were given. In areas of very high and high incidence rates, a combination of population-based and individual prevention strategies is preferable while in other areas a combination of high-risk and individual strategies is recommended. Discussion. Epidemiologic zoning should be the basis of a risk-based approach to determining optimal volumes and directions of preventive measures against natural focal infections. It is necessary to improve the means and methods of determining the individual risk of getting infected and developing tick-borne infectious diseases in case of bites, in view of mixed infection of vectors, as well as methods of post-exposure disease prevention (preventive therapy).


Sign in / Sign up

Export Citation Format

Share Document