scholarly journals Pathophysiology of Gestational Diabetes Mellitus: The Past, the Present and the Future

10.5772/24315 ◽  
2011 ◽  
Author(s):  
Mohammed Chyad ◽  
Mohammed Helmy Faris Shalayel
2018 ◽  
Vol 1 (2) ◽  
pp. 94-98
Author(s):  
Mufdlilah Mufdlilah ◽  
Fijri Rachmawati

Excessive fetal weight is considered as a health issues because it increases perinatal and maternal morbidity and mortality. The prevalence of macrosomia worldwide has increased over the past 2 to 3 decades. This study aimed to determine correlation between the incidence of gestational diabetes mellitus and macrosomia among pregnant women. The design of this study was analytical with a case control approach. Data used to analyze the incidence of macrosomia based on secondary data from 2014-2018. This research suggested that diabetes mellitus in pregnancy has a significant relationship with the incidence of macrosomia.


2013 ◽  
Vol 4 (2) ◽  
pp. 127-139
Author(s):  
Vincent Wing-Ming Wong

Gestational diabetes mellitus (GDM) is a condition that affects the wellbeing of mother and fetus. Women with GDM are at risk of type 2 diabetes mellitus in the future, while fetal exposure to hyperglycaemia in-utero may affect their glycometabolic profile later in life. Appropriate screening and management of this problem is important in ensuring good pregnancy outcomes. In this review, the clinical implications, the various ways to screen and diagnose GDM, and management strategies during pregnancy will be discussed. For years, insulin is the mainstay of treatment if medical nutrition therapy fails to maintain adequate glycaemic control, but use of other oral pharmacotherapy may gain greater acceptance in the future. Following delivery, ongoing follow-up of these women is worthwhile as early intervention through lifestyle or pharmacotherapy may prevent the development of diabetes.


PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252442
Author(s):  
Dayeon Shin ◽  
Kyung Won Lee

Despite the importance of pre-pregnancy body mass index (BMI) and a history of gestational diabetes mellitus (GDM) in the progression of GDM to type 2 diabetes, few studies have evaluated the combined effect of high pre-pregnancy BMI and GDM status on the future development of type 2 diabetes in Korean women. This study aimed to examine the relationship of pre-pregnancy BMI and GDM history with the risk of type 2 diabetes among Korean women. In addition, the effects of pre-pregnancy BMI and current BMI on the risk of type 2 diabetes were evaluated. Women who gave birth in the Health Examinees Study of the Korean Genome and Epidemiology Study from 2004 to 2013 (n = 59,258) were included in this study. Multivariable logistic regression was used to examine the association of pre-pregnancy BMI categories (underweight: <18.5 kg/m2; normal: 18.5–22.9 kg/m2; overweight: 23.0–24.9 kg/m2; obese: ≥25.0 kg/m2) and GDM history with the risk of type 2 diabetes after controlling for the following covariates: age, education, income, smoking status before the first pregnancy, alcohol consumption, regular exercise, menarche age, first pregnancy age, and first pregnancy outcome. Compared to women with normal pre-pregnancy BMIs, women with overweight and obese pre-pregnancy BMIs had higher odds of developing type 2 diabetes (adjusted odds ratio [AOR]: 1.13, 95% confidence interval [CI]: 1.02–1.25 and AOR: 1.29, 95% CI: 1.10–1.50, respectively) after controlling for covariates. Women with pre-pregnancy BMIs <23 kg/m2 and current BMIs ≥23 kg/m2 had increased odds of developing type 2 diabetes (AOR: 1.64, 95% CI: 1.51–1.78) compared to those with pre-pregnancy BMIs <23 kg/m2 and current BMIs <23 kg/m2. Among women without a history of GDM, those with overweight and obese pre-pregnancy BMIs had increased odds of developing type 2 diabetes compared to those with normal pre-pregnancy BMIs (AOR: 1.12, 95% CI: 1.01–1.24 and AOR: 1.23, 95% CI: 1.05–1.44, respectively). Among women with GDM, those with obese pre-pregnancy BMIs had increased odds of developing type 2 diabetes (AOR: 3.84, 95% CI: 1.52–9.87). This study showed that there was a higher likelihood of developing type 2 diabetes in women who were overweight or obese before pregnancy with a history of GDM compared to their counterparts without a history of GDM. Furthermore, high pre-pregnancy BMI or high current BMI increased the risk of type 2 diabetes in Korean women, regardless of GDM history. This emphasizes the importance of maintaining a healthy weight status before and after pregnancy to prevent the future risk of type 2 diabetes.


2021 ◽  
Vol 27 (2) ◽  
pp. 175-185
Author(s):  
Junglim Lee ◽  
Youngji Kim ◽  
Eunju Kwak ◽  
Seungmi Park

Purpose: The aim of this study was to identify core keywords and topic groups in the ‘Gestational diabetes mellitus (GDM) and Breastfeeding’ field of research for better understanding research trends in the past 20 years.Methods: This was a text-mining and topic modeling study composed of four steps: 1) collecting abstracts, 2) extracting and cleaning semantic morphemes, 3) building a co-occurrence matrix, and 4) analyzing network features and clustering topic groups.Results: A total of 635 papers published between 2001 and 2020 were found in databases (Web of Science, CINAHL, RISS, DBPIA, RISS, KISS). Among them, 3,639 words extracted from 366 articles selected according to the conditions were analyzed by text network analysis and topic modeling. The most important keywords were 'exposure', ‘fetus’, ‘hypoglycemia’, 'prevention' and 'program'. Six topic groups were identified through topic modeling. The main topics of the study were ‘cardiovascular disease' and 'obesity'. Through the topic modeling analysis, six themes were derived: ‘cardiovascular disease’, ‘obesity’, ‘complication prevention strategy’, ‘support of breastfeeding’, ‘educational program’ and ‘management of GDM’.Conclusion: This study showed that over the past 20 years many studies have been conducted on complications such as cardiovascular diseases and obesity related to gestational diabetes and breastfeeding. In order to prevent complications of gestational diabetes and promote breastfeeding, various nursing interventions, including gestational diabetes management and educational programs for GDM pregnancies, should be developed in nursing fields.


2013 ◽  
Vol 4 (2) ◽  
pp. 127
Author(s):  
Vincent Wing-Ming Wong

Gestational diabetes mellitus (GDM) is a condition that affects the wellbeing of mother and fetus. Women with GDM are at risk of type 2 diabetes mellitus in the future, while fetal exposure to hyperglycaemia in-utero may affect their glycometabolic profile later in life. Appropriate screening and management of this problem is important in ensuring good pregnancy outcomes. In this review, the clinical implications, the various ways to screen and diagnose GDM, and management strategies during pregnancy will be discussed. For years, insulin is the mainstay of treatment if medical nutrition therapy fails to maintain adequate glycaemic control, but use of other oral pharmacotherapy may gain greater acceptance in the future. Following delivery, ongoing follow-up of these women is worthwhile as early intervention through lifestyle or pharmacotherapy may prevent the development of diabetes.


2016 ◽  
Vol 22 ◽  
pp. 233-234
Author(s):  
Md Abdullah Mamun ◽  
Subrina Jesmin ◽  
Md. Arifur Rahman ◽  
Md Majedul Islam ◽  
Farzana Sohael ◽  
...  

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