scholarly journals Differences in Erythrocyte Index and Hyporesponsiveness to Erythropoiesis in Hemodialysis Patients Treated with Different Erythropoiesis-Stimulating Agents

10.5772/24092 ◽  
2011 ◽  
Author(s):  
Osamu Saito ◽  
Yoichi Furusawa ◽  
Kousuke Okuda ◽  
Eiji Kusano
Keyword(s):  
Hemodialysis Patients ◽  
Erythropoiesis Stimulating Agents

scholarly journals Comparison between short- and long-acting erythropoiesis-stimulating agents in hemodialysis patients: target hemoglobin, variability, and outcome

2014 ◽  
Vol 46 (2) ◽  
pp. 453-459 ◽  
Author(s):  
Bassam Bernieh ◽  
Samra Abouchacra ◽  
Yousef Boobes ◽  
Mohammad R. Al Hakim ◽  
Nico Nagelkerke ◽  
...  
Keyword(s):  
Hemodialysis Patients ◽  
Erythropoiesis Stimulating Agents ◽  
Hemoglobin Variability ◽  
Long Acting

scholarly journals Association of malnutrition–inflammation complex and responsiveness to erythropoiesis-stimulating agents in long-term hemodialysis patients

2012 ◽  
Vol 28 (7) ◽  
pp. 1936-1945 ◽  
Author(s):  
Manoch Rattanasompattikul ◽  
Miklos Z. Molnar ◽  
Joshua J. Zaritsky ◽  
Parta Hatamizadeh ◽  
Jennie Jing ◽  
...  
Keyword(s):  
Hemodialysis Patients ◽  
Erythropoiesis Stimulating Agents

scholarly journals Predictors of Hyporesponsiveness to Erythropoiesis-Stimulating Agents in Hemodialysis Patients

2009 ◽  
Vol 53 (5) ◽  
pp. 823-834 ◽  
Author(s):  
Kamyar Kalantar-Zadeh ◽  
Grace H. Lee ◽  
Jessica E. Miller ◽  
Elani Streja ◽  
Jennie Jing ◽  
...  
Keyword(s):  
Hemodialysis Patients ◽  
Erythropoiesis Stimulating Agents

scholarly journals Role of circulating endothelial progenitors in responsiveness to erythropoiesis-stimulating agents in hemodialysis patients

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Akira Ishimitsu ◽  
Hiroshi Satonaka ◽  
Masahito Furuichi ◽  
Yoshiki Murayama ◽  
Akihiro Tojo ◽  
...  
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Linear Regression Analysis ◽  
Resistance Index ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis ◽  
University Hospital ◽  
Cardiovascular Risks ◽  
Persistent Problem ◽  
Erythropoiesis Stimulating Agents

Abstract Background Though treatment of anemia in chronic kidney disease (CKD) patients has been improved remarkably by erythropoiesis-stimulating agents (ESA), hypo-responsiveness to ESA poses a persistent problem in a subgroup of CKD patients, especially those on dialysis, with deteriorated mortality or cardiovascular risks. Pathomechanism of this condition including cardiovascular implications has not been sufficiently investigated. Methods Clinical parameters of 101 chronic hemodialysis patients which included those hospitalized in our university hospital were examined cross-sectionally. As a marker estimating ESA hypo-responsiveness, erythropoietin resistance index (ERI) was calculated. Numbers of circulating endothelial progenitor cells (EPC) were measured by flow cytometry. Associations among values were analyzed by methods including multiple linear regression. Results Majority (93%) of the subjects were hospitalized patients with various comorbidities. ERI (18.4 [7.2–33.0] IU/week/kg/g/dL) and ESA dose (161.6 [75.0–320.9] IU/week/kg) of all the subjects were relatively high. Factors negatively correlated with EPC included age, HD vintage, CRP, pulse rate, ESA dose and ERI, while male sex and systolic blood pressure were positively correlated. By multiple linear regression analysis, age, sex and ERI (standardized coefficient beta − 0.202, p = 0.039) remained as the independently predicting factors of EPC (log CD133/Flk1+ EPC). Darbepoetin alpha was used in 65 patients, especially predominant when requiring higher ESA doses, but by correlation or multivariable analyses, this did not substantially modify the negative association between ERI and EPC. Conclusions ERI was independently associated with EPC paucity in a cohort with various comorbidities. This may suggest a link which connects ESA hypo-responsiveness to compromised cardiovascular prognosis of dialysis patients.

scholarly journals Low versus high dose erythropoiesis-stimulating agents in hemodialysis patients with anemia: A randomized clinical trial

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0172735 ◽  
Author(s):  
Valeria Saglimbene ◽  
Suetonia C. Palmer ◽  
Jonathan C. Craig ◽  
Marinella Ruospo ◽  
Antonio Nicolucci ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Hemodialysis Patients ◽  
High Dose ◽  
Erythropoiesis Stimulating Agents
Sign in / Sign up

Export Citation Format

Share Document