scholarly journals Role of Triglyceride/Fatty Acid Cycle in Development of Type 2 Diabetes

10.5772/24033 ◽  
2011 ◽  
Author(s):  
Chang-Wen Hsieh ◽  
David DeSantis ◽  
Colleen M
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acid ◽  
Acid Cycle ◽  
Triglyceride Fatty Acid

scholarly journals Circulating Adipocyte Fatty Acid–Binding Protein Concentrations Predict Multiple Mortality Outcomes among Men and Women with Diabetes

2018 ◽  
Vol 64 (10) ◽  
pp. 1496-1504 ◽  
Author(s):  
Chi Ho Lee ◽  
Chloe Y Y Cheung ◽  
Yu Cho Woo ◽  
David T W Lui ◽  
Michele M A Yuen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Independent Predictor ◽  
Fatty Acid Binding ◽  
Men And Women ◽  
Acid Binding Protein ◽  
All Cause Mortality

AbstractINTRODUCTIONRaised circulating adipocyte fatty acid–binding protein (AFABP) concentrations are associated with various adverse health conditions. However, their relationship with mortality remains to be defined, especially in view of the sexual dimorphism of circulating AFABP concentrations. Here we investigated prospectively whether serum AFABP concentrations predict multiple mortality outcomes in men and women alike, using a large clinic-based cohort of individuals with type 2 diabetes, a condition with raised AFABP concentrations.METHODSBaseline serum AFABP concentrations were measured in 5305 research participants with a monoclonal antibody-based sandwich immunoassay. The role of circulating AFABP concentrations in predicting mortality outcomes was evaluated by multivariable Cox regression analysis.RESULTSAmong the 5305 participants (59% men) in this study, over a median follow-up of 5 years, there were 512 deaths (19.3 deaths per 1000 person-years). Circulating AFABP concentrations, with higher levels in women at baseline, predicted all-cause mortality (P < 0.001), cardiovascular mortality (P = 0.037), and infection-related deaths (P < 0.002) among all participants. In sex-specific analyses, circulating AFABP concentration was an independent predictor of all-cause mortality in both men and women and a predictor of cancer-related deaths and infection-related deaths in men only. Furthermore, the addition of serum AFABP concentrations improved the time-dependent c statistics in predicting all-cause mortality in participants with type 2 diabetes (P = 0.008).CONCLUSIONSCirculating AFABP concentration was an independent predictor of various mortality outcomes in type 2 diabetes over and above known risk factors of reduced survival in men and women. The role of AFABP as a prognostic biomarker and therapeutic target warrants further investigation.

Role of 14-3-3η protein on cardiac fatty acid metabolism and macrophage polarization after high fat diet induced type 2 diabetes mellitus

2017 ◽  
Vol 88 ◽  
pp. 92-99 ◽  
Author(s):  
Remya Sreedhar ◽  
Somasundaram Arumugam ◽  
Rajarajan A. Thandavarayan ◽  
Vengadeshprabhu Karuppagounder ◽  
Yusuke Koga ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Fatty Acid ◽  
High Fat Diet ◽  
Acid Metabolism ◽  
Macrophage Polarization ◽  
High Fat

The role of oncostatin m in the development of type 2 diabetes associated with obesity

2018 ◽  
Author(s):  
Siri Taxeras ◽  
Irene Piquer-Garcia ◽  
Silvia Pellitero ◽  
Rocio Puig ◽  
Eva Martinez ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Oncostatin M

1709-P: Assessing the Role of 211 “Established” Type 2 Diabetes Variants in American Indians

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1709-P
Author(s):  
ROBERT L. HANSON ◽  
LAUREN E. WEDEKIND ◽  
WEN-CHI HSUEH ◽  
SAYUKO KOBES ◽  
LESLIE J. BAIER ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
American Indians

1758-P: Type 2 Diabetes–Associated Mood Disorders: Role of Insulin Resistance in Serotonergic Neurons

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1758-P
Author(s):  
HUGO MARTIN ◽  
SÉBASTIEN BULLICH ◽  
FABIEN DUCROCQ ◽  
MARION GRALAND ◽  
CLARA OLIVRY ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Mood Disorders ◽  
Serotonergic Neurons ◽  
P Type
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