scholarly journals New Therapeutic Strategies for the Treatment of Brain Tumor

10.5772/23997 ◽  
2011 ◽  
Author(s):  
Rintaro Hashizume
Keyword(s):  
Brain Tumor ◽  
Therapeutic Strategies

scholarly journals Friend or Foe: Paradoxical Roles of Autophagy in Gliomagenesis

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1411
Author(s):  
Don Carlo Ramos Batara ◽  
Moon-Chang Choi ◽  
Hyeon-Uk Shin ◽  
Hyunggee Kim ◽  
Sung-Hak Kim
Keyword(s):  
Brain Tumor ◽  
Glioblastoma Multiforme ◽  
Cancer Biology ◽  
Molecular Mechanisms ◽  
Primary Brain Tumor ◽  
Molecular Target ◽  
Therapeutic Strategies ◽  
Homeostatic Mechanism ◽  
Cellular Context ◽  
Cellular Components

Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor in adults, with a poor median survival of approximately 15 months after diagnosis. Despite several decades of intensive research on its cancer biology, treatment for GBM remains a challenge. Autophagy, a fundamental homeostatic mechanism, is responsible for degrading and recycling damaged or defective cellular components. It plays a paradoxical role in GBM by either promoting or suppressing tumor growth depending on the cellular context. A thorough understanding of autophagy’s pleiotropic roles is needed to develop potential therapeutic strategies for GBM. In this paper, we discussed molecular mechanisms and biphasic functions of autophagy in gliomagenesis. We also provided a summary of treatments for GBM, emphasizing the importance of autophagy as a promising molecular target for treating GBM.

scholarly journals Long Non-Coding RNAs in Multidrug Resistance of Glioblastoma

Genes ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 455
Author(s):  
Parvaneh Mahinfar ◽  
Behzad Baradaran ◽  
Sadaf Davoudian ◽  
Fatemeh Vahidian ◽  
William Chi-Shing Cho ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Multidrug Resistance ◽  
Therapeutic Strategies ◽  
Chemotherapeutic Agents ◽  
The Other ◽  
The Common ◽  
Non Coding Rnas ◽  
Underlying Mechanisms ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

Glioblastoma, also known as glioblastoma multiforme, is the most aggressive brain tumor in adults. Despite the huge advance in developing novel therapeutic strategies for patients with glioblastoma, the appearance of multidrug resistance (MDR) against the common chemotherapeutic agents, including temozolomide, is considered as one of the important causes for the failure of glioblastoma treatment. On the other hand, recent studies have demonstrated the critical roles of long non-coding RNAs (lncRNAs), particularly in the development of MDR in glioblastoma. Therefore, this article aimed to review lncRNA’s contribution to the regulation of MDR and elucidate the underlying mechanisms in glioblastoma, which will open up new lines of inquiry in the treatment of glioblastoma.

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