scholarly journals The Potential of Biomimetic Electrospun-Nanofibrous Scaffolds for Bone Tissue Engineering

10.5772/23939 ◽  
2011 ◽  
Author(s):  
Ha Na ◽  
Jung Bok ◽  
Ho-Jin Moon ◽  
Dae Hyeok ◽  
Il Keun
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Nanofibrous Scaffolds

scholarly journals Zein/gelatin/nanohydroxyapatite nanofibrous scaffolds are biocompatible and promote osteogenic differentiation of human periodontal ligament stem cells

2019 ◽  
Vol 7 (5) ◽  
pp. 1973-1983 ◽  
Author(s):  
Qianmin Ou ◽  
Yingling Miao ◽  
Fanqiao Yang ◽  
Xuefeng Lin ◽  
Li-Ming Zhang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Bone Tissue Engineering ◽  
Osteogenic Differentiation ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Periodontal Ligament ◽  
Periodontal Ligament Stem Cells ◽  
Nanofibrous Scaffolds

In bone tissue engineering, it is important for biomaterials to promote the osteogenic differentiation of stem cells to achieve tissue regeneration.

Functionalization of Nanofibrous Spiral Structured Scaffolds for Bone Tissue Engineering

2009 ◽  
Vol 1235 ◽  
Author(s):  
Junping Wang ◽  
Xiaojun Yu
Keyword(s):  
Tissue Engineering ◽  
Cell Proliferation ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Spiral Structure ◽  
Nutrient Transport ◽  
Structure Design ◽  
Cellular Growth ◽  
Osteoblast Cells ◽  
Nanofibrous Scaffolds

AbstractIn the previous studies, we have successfully developed a novel spiral structured nanofibrous scaffolds with improved osteoconductivity for bone tissue engineering. The spiral structure design facilitates the nutrient transport and waste removal, and allows uniform cellular growth and distribution within the scaffolds, thus enhanced the bioactivity of the scaffolds. In this chapter, HAP and BMP-2 were incorporated within the nanofibrous spiral scaffolds in order to enhance the osteoinductivity of the established system. The effect of the blending materials was evaluated through cell proliferation, cell differentiation of human osteoblast cells seeded on the scaffolds and cultured for 4 and 8 days. The results has demonstrated that the functionalization of PCL nanofibrous spiral scaffolds leads to higher ALP expression level and increased amount of mineralization level however lower cell proliferation rate.

scholarly journals Controlled degradability of PCL-ZnO nanofibrous scaffolds for bone tissue engineering and their antibacterial activity

2018 ◽  
Vol 93 ◽  
pp. 724-738 ◽  
Author(s):  
Betiana Felice ◽  
María Alejandra Sánchez ◽  
María Cecilia Socci ◽  
Luciano David Sappia ◽  
María Inés Gómez ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Antibacterial Activity ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Nanofibrous Scaffolds

scholarly journals Recent Developments in Nanofiber Fabrication and Modification for Bone Tissue Engineering

2019 ◽  
Vol 21 (1) ◽  
pp. 99 ◽  
Author(s):  
Nopphadol Udomluck ◽  
Won-Gun Koh ◽  
Dong-Jin Lim ◽  
Hansoo Park
Keyword(s):  
Tissue Engineering ◽  
Growth Factors ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Cells ◽  
Potential Candidate ◽  
Cell Functions ◽  
Nanofibrous Scaffolds ◽  
Essential Components ◽  
Post Modification

Bone tissue engineering is an alternative therapeutic intervention to repair or regenerate lost bone. This technique requires three essential components: stem cells that can differentiate into bone cells, growth factors that stimulate cell behavior for bone formation, and scaffolds that mimic the extracellular matrix. Among the various kinds of scaffolds, highly porous nanofibrous scaffolds are a potential candidate for supporting cell functions, such as adhesion, delivering growth factors, and forming new tissue. Various fabricating techniques for nanofibrous scaffolds have been investigated, including electrospinning, multi-axial electrospinning, and melt writing electrospinning. Although electrospun fiber fabrication has been possible for a decade, these fibers have gained attention in tissue regeneration owing to the possibility of further modifications of their chemical, biological, and mechanical properties. Recent reports suggest that post-modification after spinning make it possible to modify a nanofiber’s chemical and physical characteristics for regenerating specific target tissues. The objectives of this review are to describe the details of recently developed fabrication and post-modification techniques and discuss the advanced applications and impact of the integrated system of nanofiber-based scaffolds in the field of bone tissue engineering. This review highlights the importance of nanofibrous scaffolds for bone tissue engineering.

scholarly journals Nanofibrous Scaffolds Containing Hydroxyapatite and Microfluidic-Prepared Polyamidoamin/BMP-2 Plasmid Dendriplexes for Bone Tissue Engineering Applications

2020 ◽  
Vol Volume 15 ◽  
pp. 2633-2646 ◽  
Author(s):  
Mehdi Doosti-Telgerd ◽  
Fatemeh Sadat Mahdavi ◽  
Farzad Moradikhah ◽  
Mohammad Porgham Daryasari ◽  
Rahimeh Bayrami Atashgah ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Applications ◽  
Nanofibrous Scaffolds
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