scholarly journals EMR and ESD for Gastrointestinal Neoplasms

10.5772/23701 ◽  
2011 ◽  
Author(s):  
Keiichiro Kume
Keyword(s):  
Gastrointestinal Neoplasms

scholarly journals Gastrointestinal Stromal Tumors (GISTs): Novel Therapeutic Strategies with Immunotherapy and Small Molecules

2021 ◽  
Vol 22 (2) ◽  
pp. 493
Author(s):  
Christos Vallilas ◽  
Panagiotis Sarantis ◽  
Anastasios Kyriazoglou ◽  
Evangelos Koustas ◽  
Stamatios Theocharis ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitors ◽  
Gastrointestinal Stromal Tumors ◽  
Kinase Inhibitors ◽  
Checkpoint Inhibitors ◽  
Survival Rates ◽  
Cancer Therapeutics ◽  
Gastrointestinal Neoplasms ◽  
Mesenchymal Tumors ◽  
Stromal Tumors

Gastrointestinal stromal tumors (GISTs) are the most common types of malignant mesenchymal tumors in the gastrointestinal tract, with an estimated incidence of 1.5/100.000 per year and 1–2% of gastrointestinal neoplasms. About 75–80% of patients have mutations in the KIT gene in exons 9, 11, 13, 14, 17, and 5–10% of patients have mutations in the platelet-derived growth factor receptor a (PDGFRA) gene in exons 12, 14, 18. Moreover, 10–15% of patients have no mutations and are classified as wild type GIST. The treatment for metastatic or unresectable GISTs includes imatinib, sunitinib, and regorafenib. So far, GIST therapies have raised great expectations and offered patients a better quality of life, but increased pharmacological resistance to tyrosine kinase inhibitors is often observed. New treatment options have emerged, with ripretinib, avapritinib, and cabozantinib getting approvals for these tumors. Nowadays, immune checkpoint inhibitors form a new landscape in cancer therapeutics and have already shown remarkable responses in various tumors. Studies in melanoma, non-small-cell lung cancer, and renal cell carcinoma are very encouraging as these inhibitors have increased survival rates. The purpose of this review is to present alternative approaches for the treatment of the GIST patients, such as combinations of immunotherapy and novel inhibitors with traditional therapies (tyrosine kinase inhibitors).

Krukenberg tumor secondary to gall bladder carcinoma masquerading C3 glomerulopathy

2020 ◽  
Vol 4 (3) ◽  
pp. 105-108
Author(s):  
Priti Meena ◽  
Vinant Bhargava ◽  
Devinder Singh Rana ◽  
Anil Kumar Bhalla ◽  
Ashwani Gupta ◽  
...  
Keyword(s):  
Gall Bladder ◽  
Bladder Carcinoma ◽  
Case Reports ◽  
Abdominal Distension ◽  
Gastrointestinal Neoplasms ◽  
Solid Organ ◽  
Krukenberg Tumor ◽  
C3 Glomerulopathy ◽  
Gall Bladder Carcinoma ◽  
Loss Of Appetite

Background: C3 glomerulopathy is caused by dysregulation of the alternative complement pathway. Association with solid organ tumors is rare. However, there have been a few case reports of membranoproliferative glomerulonephritis secondary to gastrointestinal neoplasms. Case: A 38-year-old female presented with abdominal distension, loss of appetite, amenorrhea, and easy fatigability. She had been diagnosed 8 months back with C3 glomerulopathy and had received immunosuppression. On evaluation, she was incidentally detected to have Krukenberg tumor. The primary site of malignancy was gall bladder. Conclusion: Our case report highlights a possible association between C3 glomerulopathy and Krukenberg tumor secondary to gall bladder carcinoma and emphasizes the fact that even in cases of C3 glomerulopathy, occult malignancy should be considered as an underlying pathology.

Mo1656 Microsatellite Instability of the Gastric and Colorectal Cancers As a Predictor for Synchronous Gastrointestinal Neoplasms

2014 ◽  
Vol 146 (5) ◽  
pp. S-628
Author(s):  
Young Baek Kim ◽  
Sun-Young Lee ◽  
Jeong Hwan Kim ◽  
In Kyung Sung ◽  
Hyung Seok Park ◽  
...  
Keyword(s):  
Microsatellite Instability ◽  
Gastrointestinal Neoplasms ◽  
Colorectal Cancers

Application of Immunohistochemistry to Liver and Gastrointestinal Neoplasms: Liver, Stomach, Colon, and Pancreas

2008 ◽  
Vol 132 (3) ◽  
pp. 490-499 ◽  
Author(s):  
Stephen A. Geller ◽  
Deepti Dhall ◽  
Randa Alsabeh
Keyword(s):  
Gastrointestinal Tract ◽  
Personal Experience ◽  
Recent Literature ◽  
Malignant Tumors ◽  
Chemotherapeutic Agents ◽  
Gastrointestinal System ◽  
Data Sources ◽  
Gastrointestinal Neoplasms ◽  
Metastatic Neoplasm ◽  
Selection Of

Abstract Context.—Immunohistochemistry has become an integral component of the practice of pathology. Newer antibodies allow for increasingly precise diagnoses for tumors that previously could not be easily identified. Recently, immunohistochemical evaluations have begun to allow pathologists to actively assist in determining prognosis and even in selecting therapies. Objective.—To summarize the usefulness of currently available immunostains for the study of liver and gastrointestinal system neoplasms and to make recommendations for panels of immunostains that can be particularly helpful. Data Sources.—Information has been collected from recent literature as well as from personal experience and practice. Conclusions.—Many immunostains are now available for the practicing pathologist that allow for increasing accuracy in diagnosis of liver and gastrointestinal tract neoplasms. Panels of immunostains can be used to differentiate between various tumors and also to identify site of origin in the case of a metastatic neoplasm. Immunostains that allow for prognostic determinations and for guidance in the selection of chemotherapeutic agents can also be used by pathologists to assist in the management of patients with malignant tumors affecting the liver and gastrointestinal tract.

Gastrointestinal Neoplasms in von Recklinghausenʼs Disease*

1969 ◽  
Vol 62 (10) ◽  
pp. 1237-1239 ◽  
Author(s):  
CAPT WILLIAM M. LUKASH ◽  
LTCDR R. B. JOHNSON
Keyword(s):  
Gastrointestinal Neoplasms

scholarly journals Ácido Sórbico e Câncer Gastrointestinal: uma Revisão Integrativa

2021 ◽  
Vol 24 (5-esp.) ◽  
pp. 640-644
Author(s):  
Renata Carmo de Assis ◽  
Thalyta Vasconcelos Pacheco ◽  
Ana Carolina Marinho Ferreira ◽  
Tayane Carneiro Cruz ◽  
Ana Bárbara Muniz Araújo ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Cancer ◽  
Sorbic Acid ◽  
Food Additives ◽  
Integrative Review ◽  
Potassium Sorbate ◽  
Gastrointestinal Neoplasms ◽  
Published Data ◽  
Food Preservative ◽  
Tract Cancer

A industrialização de alimentos resultou em um novo modelo alimentar altamente processado. O consumo de alimentos industrializados, aumenta a ingestão de aditivos alimentares, que possuem a função de preservação das características do alimento bem como melhorias nas propriedades sensoriais. Entretanto alguns estudos demonstram que se adicionados em quantidade elevadas para consumo podem levar a toxicidade. Assim, o objetivo do estudo foi revisar dados publicados que relacionam o uso do aditivo químico sorbato de potássio como conservante alimentar com o desenvolvimento de câncer gastrointestinal. Trata-se de uma revisão integrativa seguindo seis etapas distintas (1. Elaboração da pergunta norteadora; 2. Busca ou amostragem na literatura; 3. Coleta de dados; 4. Análise crítica dos estudos incluídos; 5. Discussão dos resultados e 6. Apresentação da revisão integrativa). Foi realizada entre os meses de março e abril de 2019 nas bases de dados: Periódicos CAPES, Pubmed, Biblioteca virtual Unicamp e Science Direct. Os descritores principais utilizados foram: “Potassium sorbate” e “Sorbic acid”, combinados com os descritores, “gastrointestinal neoplasia”, “Cancer of gastrointestinal tract” e “Neoplasia”. Após leitura dos títulos e resumos, foram incluídos oito artigos e, após leitura destes, permaneceram seis artigos. Diante dos artigos encontrados é possível afirmar que o ácido sórbico e o sorbato de potássio tem baixa relação com o desenvolvimento de câncer gastrointestinal.   Palavras-chave: Aditivos Alimentares. Ácido Sórbico. Neoplasias Gastrointestinais   Abstract Food industrialization has resulted in a new highly processed food model. The consumption of industrialized food increases the  food additives intake, which have the function of preserving the food characteristics as well as improving sensory properties. However, some studies show that if added in high amounts for consumption they can lead to toxicity. Thus, the objective of the study was to review published data that relate the use of the chemical additive potassium sorbate as a food preservative with the development of gastrointestinal cancer. It is an integrative review following six distinct steps (1. Preparation of the guiding question; 2. Searching or sampling in the literature; 3. Data collection; 4. Critical analysis of the studies included; 5. Discussion of the results and 6. Presentation of the integrative review). It was held between March and April 2019 in the databases: CAPES Periodicals, Pubmed, Virtual Library Unicamp and Science Direct. The main descriptors used were: "Potassium sorbate" and "Sorbic acid", combined with the descriptors "gastrointestinal neoplasia", " Gastrointestinal tract cancer" and "Neoplasia". After reading the titles and abstracts, eight articles were included and, after reading them, six articles remained. It is possible to affirm that sorbic acid and potassium sorbate have a low relation with the development of gastrointestinal cancer.    Keywords: Food Additives. Sorbic Acid. Gastrointestinal Neoplasms.

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