scholarly journals Intravenous Immunoglobulins in Neurological Diseases: Established and Novel Clinical Applications

10.5772/23579 ◽  
2011 ◽  
Author(s):  
Konstantina G.
Keyword(s):  
Neurological Diseases ◽  
Intravenous Immunoglobulins ◽  
Clinical Applications

Clinical Applications of Intravenous Immunoglobulins in Child Neurology

2017 ◽  
Vol 18 (8) ◽  
Author(s):  
Maria Gogou ◽  
Efimia Papadopoulou-Alataki ◽  
Martha Spilioti ◽  
Sofia Alataki ◽  
Athanasios Evangeliou
Keyword(s):  
Intravenous Immunoglobulins ◽  
Clinical Applications ◽  
Child Neurology

scholarly journals Reworsening of Recurrent Guillain-Barré Syndrome Triggered by COVID-19 Infection

2021 ◽  
Vol 15 (1) ◽  
pp. 48-51
Author(s):  
Gian Luca Vita ◽  
Carmen Terranova ◽  
Maria Sframeli ◽  
Antonio Toscano ◽  
Giuseppe Vita
Keyword(s):  
Viral Infection ◽  
Neurological Diseases ◽  
Intravenous Immunoglobulins ◽  
Guillain Barre Syndrome ◽  
Case Presentation ◽  
Appropriate Treatment ◽  
Immune Mediated ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Introduction: Guillain-Barré Syndrome (GBS) is an acute, immune-mediated, generalized polyradiculoneuropathy often triggered by a bacterial or viral infection, vaccination, or surgery. During the SARS-CoV-2 pandemic, some patients were reported with GBS associated COVID-19 infection. Case Presentation: We report, herein, a patient who had a recurrent GBS after forty years. Intravenous immunoglobulins (IVIg) induced improvement, but her condition worsened suddenly after twenty days, coinciding with a COVID-19 infection. A second IVIg cycle was administered, and she improved again. Conclusion: The take-home message is that in the current pandemic, any re-worsening or lack of improvement after appropriate treatment of GBS or possibly other autoimmune neurological diseases must be checked to determine if it is related to COVID-19 infection.

Intravenous immunoglobulins in neurological diseases

2006 ◽  
Vol 253 (S5) ◽  
pp. v1-v1
Author(s):  
Uwe K. Zettl ◽  
Eilhard Mix
Keyword(s):  
Neurological Diseases ◽  
Intravenous Immunoglobulins

The Classification of Calcium Antagonists by the WHO Expert Committee: Relevance in Neurology

Cephalalgia ◽  
1988 ◽  
Vol 8 (8_suppl) ◽  
pp. 7-10 ◽  
Author(s):  
A Agnoli
Keyword(s):  
Calcium Antagonists ◽  
Neurological Disorders ◽  
Neurological Diseases ◽  
Clinical Applications ◽  
Migraine Prophylaxis ◽  
Brain Cells ◽  
Expert Committee ◽  
New Classification ◽  
Classification Of Calcium Antagonists

A new classification of calcium antagonists has been developed by a WHO expert committee. Substances acting primarily via the inhibition of calcium entry into the cell have been divided into four distinct classes. The pharmacological characteristics of these classes that may be relevant for the use in various neurological disorders are highlighted in this paper. Some main differences concern the effects on vascular smooth muscle cells and brain cells. The well-documented clinical applications in neurology are still limited to migraine prophylaxis and vertigo. The evidence concerning the usefulness in cerebral vasospasm secondary to subarachnoid haemorrhage was regarded as reasonable, whereas several neurological indications should still be regarded as being under examination. There is little doubt that calcium antagonists will gain importance in the treatment of several neurological diseases.

scholarly journals Clinical applications of immunoglobulin in neuromuscular diseases: focus on inflammatory myopathies

2014 ◽  
Vol 72 (12) ◽  
pp. 966-971
Author(s):  
Paulo Victor Sgobbi de Souza ◽  
Wladimir Bocca Vieira de Rezende Pinto ◽  
Acary Souza Bulle Oliveira
Keyword(s):  
Intravenous Immunoglobulin ◽  
Mechanism Of Action ◽  
Neurological Diseases ◽  
Clinical Manifestations ◽  
Neuromuscular Diseases ◽  
Clinical Applications ◽  
Inflammatory Myopathies ◽  
Pathophysiological Mechanisms ◽  
Therapeutic Uses ◽  
Immune Mediated

During recent years, an increasing number of neuromuscular diseases have been recognized either to be caused primarily by autoimmune mechanisms, or to have important autoimmune components. The involved pathophysiological mechanisms and clinical manifestations have been better recognized and many of these disorders are potentially treatable by immunosuppression or by immunomodulation with intravenous immunoglobulin (IVIg). IVIg has been tried in a variety of immune-mediated neurological diseases, being target of widespread use in central and peripheral nervous systems diseases. Objective To give an overview of the main topics regarding the mechanism of action and different therapeutic uses of IVIg in neurological practice, mainly in neuromuscular diseases.

scholarly journals Potential Clinical Applications of Exosomal Circular RNAs: More than Diagnosis

2021 ◽  
Vol 8 ◽  
Author(s):  
Kearabetsoe Matseliso Molibeli ◽  
Rong Hu ◽  
Yuze Liu ◽  
Dehui Xiong ◽  
Lijun Tang
Keyword(s):  
Rna Binding ◽  
Neurological Diseases ◽  
Cell Communication ◽  
Clinical Applications ◽  
Circular Rnas ◽  
Control Gene Expression ◽  
Genome Wide ◽  
Potential Applications ◽  
Non Coding Rnas ◽  
Regulatory Functions

Exosomes are small vesicles derived from cells used as cell-to-cell communication goods in numerous diseases including tumorigenesis, neurological diseases, cardiovascular diseases and other diseases. Circular RNAs (circRNAs) are an innovative constituent of non-coding endogenous RNAs generated through backsplicing, catalyzed by RNA polymerase Ⅱ. These non-coding RNAs have been suggested to control gene expression through miRNA sponging, RNA-binding protein regulation and translational capabilities. Genome-wide RNA sequence analyses observed that circRNAs were stably improved in exosomes in association to parental cells. Little attention has been dedicated to exosomal circRNAs (exo-circRNAs). However, research has demonstrated that exo-circRNAs may have important regulatory functions because of their stability in cells and within exosomes. If well understood, the precise roles and mechanisms of exo-circRNAs might surge the impending clinical applications of these molecules as markers in the identification, prediction and treatment of various diseases. In this review, we outline recent findings regarding exo-circRNAs which includes their functions and highlights their potential applications and therapeutic targets in human diseases.

scholarly journals Clinical applications of intravenous immunoglobulins in neurology

2009 ◽  
Vol 158 ◽  
pp. 34-42 ◽  
Author(s):  
R. A. C. Hughes ◽  
M. C. Dalakas ◽  
D. R. Cornblath ◽  
N. Latov ◽  
M. E. Weksler ◽  
...  
Keyword(s):  
Intravenous Immunoglobulins ◽  
Clinical Applications

scholarly journals Clinical applications of intravenous immunoglobulins (IVIg) - beyond immunodeficiencies and neurology

2009 ◽  
Vol 158 ◽  
pp. 23-33 ◽  
Author(s):  
H.-P. Hartung ◽  
L. Mouthon ◽  
R. Ahmed ◽  
S. Jordan ◽  
K. B. Laupland ◽  
...  
Keyword(s):  
Intravenous Immunoglobulins ◽  
Clinical Applications
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