scholarly journals Quantitative Determination of Drugs in Dosage Forms as a Tool of Quality Control Studies

10.5772/23475 ◽  
2011 ◽  
Author(s):  
Sigrid Mennickent ◽  
Marta de ◽  
Mario Vega ◽  
Carmen Gloria
Keyword(s):  
Quality Control ◽  
Quantitative Determination ◽  
Dosage Forms

GLC Determination of the Optical Isomers of Amphetamine

1970 ◽  
Vol 53 (1) ◽  
pp. 113-115
Author(s):  
Clyde E Wells
Keyword(s):  
Quantitative Determination ◽  
Calibration Curve ◽  
Collaborative Study ◽  
Isomeric Ratio ◽  
Dosage Forms ◽  
Optical Isomers ◽  
Standard Calibration ◽  
Tablet Dosage

Abstract A method is described for the quantitative determination of the ratio of d- and l-amphetamine stereoisomers by GLC. A derivative formed with N-trifluoroacetyl-(l)-prolyl chloride is chromatographed and the isomeric ratio is read from a standard calibration curve. The method is applicable to crystalline salts of amphetamine and to commercial tablet dosage forms. It is recommended that this method be subjected to collaborative study.

scholarly journals Spectrophotometric Determination of Ritodrine and Isoxsuprine Hydrochlorides Using 4-Aminoantipyrine

2000 ◽  
Vol 83 (6) ◽  
pp. 1440-1445 ◽  
Author(s):  
Hosakere D Revanasiddappa ◽  
Bochhe Gowda Manju
Keyword(s):  
Quantitative Determination ◽  
Rapid Method ◽  
Spectrophotometric Determination ◽  
Dosage Forms ◽  
Oxidizing Agent ◽  
Ritodrine Hydrochloride ◽  
Colored Product

Abstract A simple, accurate, and rapid method for the quantitative determination of ritodrine hydrochloride (RTH) and isoxsuprine hydrochloride (ISH) in both pure and dosage forms, is described. The method is based on the development of pink colored product as a result of the condensation of 4-aminoantipyrine with phenols in the presence of an alkaline oxidizing agent. The resulting products are measured at 510 nm for both drugs, with molar absorptivities of 0.98 × 104 and 1.20 × 104 L/mol·cm for RTH and ISH, respectively. A study of the effect of commonly associated excipients revealed that they did not cause interference.

Innovative NSAID dosage forms: lornoxicam suppositories and their standardization

2021 ◽  
pp. 71-76
Author(s):  
Viktoriya Viktorovna Skupchenko ◽  
Ekaterina Nikolaevna Mekhonoshina
Keyword(s):  
Standard Deviation ◽  
Quantitative Determination ◽  
Relative Standard Deviation ◽  
Absorption Spectra ◽  
Dosage Forms ◽  
Uv Spectrophotometry ◽  
Relative Standard ◽  
Standard Solutions

The article presents the studies on the development of a method for the quantitative determination of lornoxime in suppositories using UV spectrophotometry. The optical densities of the test solutions were recorded at a wavelength of 375 nm. The absorption spectra of standard solutions of lornoxicam, as well as of tested solutions of suppositories were obtained. The relative standard deviation was 2.31%.

Application of the high-resolution HPLC–MS/MS method for identification and quantitative determination of impurities in the substance of the drug «Lomustine»

2021 ◽  
pp. 68-70 ◽  
Author(s):  
I.O. Reshetnikova ◽  
S.V. Metlitskikh ◽  
N.D. Stekleneva ◽  
A.N. Volov
Keyword(s):  
Quality Control ◽  
High Resolution ◽  
Quantitative Determination ◽  
Russian Federation ◽  
Malignant Tumors ◽  
Medical Industry ◽  
Medicinal Substances ◽  
The Russian Federation ◽  
Determination Of Impurities

Due to the state program of the Russian Federation "Development of the pharmaceutical and medical industry" (Pharma-2020), extended until 2024, the interest in the possibility of organizing the production and quality control of imported medicinal substances directly on the territory of the Russian Federation has significantly increased. In this case, the drugs included in the lists of "Indispensible and essential drugs" and "Provision of necessary drugs" [1] are of particular importance. One of the drugs often used in the chemotherapy of malignant tumors is the drug "Lomustine", which includes 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea as an active ingredient [1-3].

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