Gray or White? – The Contribution of Gray Matter in a Glioma to Language Deficits

FT-IR microspectroscopic analysis of diseased white matter brain tissues

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100141214 ◽

1995 ◽

Vol 53 ◽

pp. 968-969

Author(s):

Steven M. Le Vine ◽

David L. Wetzel

Keyword(s):

White Matter ◽

Gray Matter ◽

Twitcher Mouse ◽

Grid Pattern ◽

Marked Contrast ◽

Spatially Resolved ◽

Ft Ir ◽

Ir Microspectroscopy ◽

Chemical Evidence

In situ FT-IR microspectroscopy has allowed spatially resolved interrogation of different parts of brain tissue. In previous work the spectrrscopic features of normal barin tissue were characterized. The white matter, gray matter and basal ganglia were mapped from appropriate peak area measurements from spectra obtained in a grid pattern. Bands prevalent in white matter were mostly associated with the lipid. These included 2927 and 1469 cm-1 due to CH2 as well as carbonyl at 1740 cm-1. Also 1235 and 1085 cm-1 due to phospholipid and galactocerebroside, respectively (Figs 1and2). Localized chemical changes in the white matter as a result of white matter diseases have been studied. This involved the documentation of localized chemical evidence of demyelination in shiverer mice in which the spectra of white matter lacked the marked contrast between it and gray matter exhibited in the white matter of normal mice (Fig. 3).The twitcher mouse, a model of Krabbe’s desease, was also studied. The purpose in this case was to look for a localized build-up of psychosine in the white matter caused by deficiencies in the enzyme responsible for its breakdown under normal conditions.

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Assessing the Use of Age-Equivalent Scores in Clinical Management

Language Speech and Hearing Services in Schools ◽

10.1044/0161-1461.2301.06 ◽

1992 ◽

Vol 23 (1) ◽

pp. 6-8 ◽

Cited By ~ 7

Author(s):

Carol W. Lawrence

Keyword(s):

Case Management ◽

Clinical Management ◽

Management Decisions ◽

Language Deficits

Speech-language evaluation reports from many institutions present age-equivalent scores as the evidence for speech-language deficits. Yet, the value and interpretation of this measurement criterion requires clinical scrutiny. This article reviews the concept and derivation of age-equivalent scores and presents arguments against their use in case management decisions.

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