scholarly journals Repair of Viral Genomes by Base Excision Pathways: African Swine Fever Virus as a Paradigm

10.5772/23328 ◽  
2011 ◽  
Author(s):  
Modesto Redrejo-Rodriguez ◽  
Javier M. ◽  
Jose Salas ◽  
Maria L.
Keyword(s):  
African Swine Fever Virus ◽  
African Swine Fever ◽  
Fever Virus ◽  
Viral Genomes ◽  
Base Excision

scholarly journals Organization of the multigene families of African Swine Fever Virus

Fine Focus ◽  
2017 ◽  
Vol 3 (2) ◽  
pp. 155-170 ◽  
Author(s):  
Jacob Imbery ◽  
Chris Upton
Keyword(s):  
African Swine Fever Virus ◽  
Sequence Divergence ◽  
African Swine Fever ◽  
Fever Virus ◽  
Multigene Families ◽  
Sequence Alignments ◽  
Multiple Sequence ◽  
Multiple Sequence Alignments ◽  
Viral Genomes ◽  
Gene Maps

African swine fever virus is a complex DNA virus that infects swine and is spread by ticks. Mortality rates in domestic pigs are very high and the virus is a significant threat to pork farming. The genomes of 16 viruses have been sequenced completely, but these represent only a few of the 23 genotypes. The viral genome is unusual in that it contains 5 multigene families, each of which contain 3-19 duplicated copies (paralogs). There is significant sequence divergence between the paralogs in a single virus and between the orthologs in the different viral genomes. This, together with the fact that in most of the multigene families there are numerous gene indels that create truncations and fusions, makes annotation of these regions very difficult; it has led to inconsistent annotation of the 16 viral genomes. In this project, we have created multiple sequence alignments for each of the multigene families and have produced gene maps to help researchers more easily understand the organization of the multigene families among the different viruses. These gene maps will help researchers ascertain which members of the multigene families are present in each of the viruses. This is critical because some of the multigene families are known to be associated with virus virulence.

Genetic markers of the African swine fever virus

2020 ◽  
Vol 23 (04) ◽  
pp. 21-26
Author(s):  
A.K. Sibgatullova ◽  
◽  
M.E. Vlasov ◽  
I.A. Titov ◽  
◽  
...  
Keyword(s):  
Genetic Markers ◽  
African Swine Fever Virus ◽  
African Swine Fever ◽  
Fever Virus

Multigene families in African swine fever virus: family 110.

1990 ◽  
Vol 64 (5) ◽  
pp. 2064-2072 ◽  
Author(s):  
J M Almendral ◽  
F Almazán ◽  
R Blasco ◽  
E Viñuela
Keyword(s):  
African Swine Fever Virus ◽  
African Swine Fever ◽  
Fever Virus ◽  
Multigene Families ◽  
Virus Family

GS-441524 inhibits African swine fever virus infection in vitro

2021 ◽  
pp. 105081
Author(s):  
Zhao Huang ◽  
Lang Gong ◽  
Zezhong Zheng ◽  
Qi Gao ◽  
Xiongnan Chen ◽  
...  
Keyword(s):  
Virus Infection ◽  
African Swine Fever Virus ◽  
African Swine Fever ◽  
Fever Virus

Adaptation of African swine fever virus to HEK293T cells

2021 ◽  
Author(s):  
Tao Wang ◽  
Liang Wang ◽  
Yu Han ◽  
Li Pan ◽  
Jing Yang ◽  
...  
Keyword(s):  
African Swine Fever Virus ◽  
African Swine Fever ◽  
Fever Virus

scholarly journals The Role of Interleukine-10 and Interferon-γ as Potential Markers of the Evolution of African Swine Fever Virus Infection in Wild Boar

Pathogens ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 757
Author(s):  
Sandra Barroso-Arévalo ◽  
Jose A. Barasona ◽  
Estefanía Cadenas-Fernández ◽  
José M. Sánchez-Vizcaíno
Keyword(s):  
Wild Boar ◽  
Vaccine Candidate ◽  
African Swine Fever Virus ◽  
African Swine Fever ◽  
Interferon Γ ◽  
Fever Virus ◽  
Control Group ◽  
Challenge Virus ◽  
Ifn Γ

African swine fever virus (ASFv) is one of the most challenging pathogens to affect both domestic and wild pigs. The disease has now spread to Europe and Asia, causing great damage to the pig industry. Although no commercial vaccine with which to control the disease is, as yet, available, some potential vaccine candidates have shown good results in terms of protection. However, little is known about the host immune mechanisms underlying that protection, especially in wild boar, which is the main reservoir of the disease in Europe. Here, we study the role played by two cytokines (IL-10 and IFN-γ) in wild boar orally inoculated with the attenuated vaccine candidate Lv17/WB/Rie1 and challenged with a virulent ASFv genotype II isolate. A group of naïve wild boar challenged with the latter isolate was also established as a control group. Our results showed that both cytokines play a key role in protecting the host against the challenge virus. While high levels of IL-10 in serum may trigger an immune system malfunctioning in challenged animals, the provision of stable levels of this cytokine over time may help to control the disease. This, together with high and timely induction of IFN-γ by the vaccine candidate, could help protect animals from fatal outcomes. Further studies should be conducted in order to support these preliminary results and confirm the role of these two cytokines as potential markers of the evolution of ASFV infection.

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