scholarly journals Obesity in the Natural History of Type 1 Diabetes Mellitus: Causes and Consequences

10.5772/23154 ◽  
2011 ◽  
Author(s):  
Fernando Valente ◽  
Marilia Brito ◽  
Sergio Atala
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Natural History ◽  
Type 1 Diabetes Mellitus ◽  
History Of

scholarly journals Accelerated Bilateral Cataract Formation as a First Manifestation of Diabetes Mellitus

2013 ◽  
Vol 114 (4) ◽  
pp. 258-262 ◽  
Author(s):  
M. R. Manaviat ◽  
Nasim Oveisi ◽  
A. Zare-Bidoki
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Emergency Room ◽  
Type 1 Diabetes Mellitus ◽  
Cataract Formation ◽  
Bilateral Cataract ◽  
Duration Of Diabetes ◽  
History Of ◽  
New Onset

There is a proved relationship between diabetes mellitus and the cataract formation. The incidence of this is usually related to the duration of diabetes. In this manuscript we report a 15 years old female presented to the emergency room with a 4 hour history of rapid bilateral diminished vision, initially diagnosed with idiopathic cataracts, but after more laboratory evaluations revealed new-onset type 1 diabetes mellitus without ketosis.

scholarly journals Pregnancy and delivery in a patient with a 40-year history of type 1 diabetes mellitus and antiphospholipid syndrome

2018 ◽  
Vol 67 (6) ◽  
pp. 93-99
Author(s):  
Roman V. Kapustin ◽  
Natalia V. Borovik ◽  
Ekaterina V. Musina ◽  
Olga N. Arzhanova ◽  
Maria I. Yarmolinskaya ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Antiphospholipid Syndrome ◽  
Perinatal Outcomes ◽  
Increased Risk ◽  
Pregnancy And Delivery ◽  
Perinatal Center ◽  
History Of

Type 1 diabetes mellitus is a condition associated with an increased risk of adverse perinatal outcomes such as spontaneous abortions, preterm birth, placental insufficiency, congenital malformations, and perinatal mortality. Diabetes mellitus combined with cardiovascular diseases in women during pregnancy often leads to hypertensive disorders and pre-eclampsia. The severity of the microvascular diabetic complications and frequency of hypoglycemic episodes, particularly in early pregnancy, are related to the risk of pre-eclampsia. We report the case of pregnancy and delivery of a live newborn in a 42-year-old woman with type 1 diabetes mellitus, pre-existing hypertension, heritable thrombophilia, and antiphospholipid syndrome. She had a 40-year history of type 1 diabetes mellitus with well-controlled diabetic nephropathy and retinopathy. The woman had been receiving continuous subcutaneous insulin therapy for the last five years, which allowed maintaining an appropriate glycemic control during pregnancy. Multidisciplinary supervision of course of pregnancy was carried out from the pre-gravidity stage until delivery and postpartum. In spite of the severe pre-eclampsia and preterm delivery by cesarean section at 36 weeks, she and newborn could avoid the intensive unit care and discharge from perinatal center without any complications.

scholarly journals Prevalence of pulmonary tuberculosis in young adult patients with Type 1 diabetes mellitus in India

2016 ◽  
Vol 11 ◽  
Author(s):  
Ravinder Goswami ◽  
Abilash Nair ◽  
Randeep Guleria ◽  
Devasenathipathy Kandasamy ◽  
Raju Sharma ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Pulmonary Tuberculosis ◽  
Type 1 Diabetes Mellitus ◽  
Sputum Culture ◽  
Mantoux Test ◽  
Care Hospital ◽  
History Of ◽  
Culture Positive

Background: There is limited information on prevalence of pulmonary tuberculosis (PTB) in patients with type-1- diabetes. We assessed the prevalence of PTB in patients with type-1-diabetes attending the outpatient-clinic in a tertiary-care hospital. Methods: 151 patients with type-1-diabetes were screened for PTB by clinical examination and chest-radiography. Sputum Acid-Fast Bacilli Test (AFB) and Mycobacterium tuberculosis (M.tb) culture were performed in patients with clinical and radiological features suggestive of a possibility of PTB and also in those with history of PTB in the past. Their average glycated haemoglobin (HbA1c) during preceding 2 years was assessed. Sputum culture positive patients were managed by a pulmonologist. Results: 5/151 patients had respiratory symptoms and radiographic findings suggestive of PTB. 20/151 patients were asymptomatic but had history of PTB. Four of the five symptomatic patients and 12 with past PTB were positive for sputum M.tb by culture, giving a prevalence of 10.6 % sputum culture positive in type-1-diabetes. Average HbA1c was comparable in patients with and without positive sputum culture. ESR and Mantoux test were not discriminatory in these groups. Four clinically symptomatic M.tb culture positive and four asymptomatic patients with sputum culture positive for M.tb on two occasions (6 weeks apart) were put on antitubercular treatment (ATT). Patients who were culture positive for M.tb only on one occasion were kept on a close follow up. Conclusions: Patients with type-1-diabetes mellitus in India have high prevalence of PTB. They need to be actively screened for PTB by sputum M.tb culture in order to initiate early treatment and to prevent transmission in the community.

scholarly journals Autoimmune Overload: An atypical presentation of granulomatosis with polyangiitis in an adolescent with type-1 diabetes mellitus

2021 ◽  
Author(s):  
Jamie Wardinger ◽  
Lauren Sussman ◽  
Breann Litwa ◽  
Elizabeth Irish ◽  
Llewellyn Foulke ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Granulomatosis With Polyangiitis ◽  
Pediatric Population ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Autoimmune Conditions ◽  
History Of ◽  
Systemic Symptoms

We report a case of granulomatosis with polyangiitis (GPA) in a pediatric patient with a history of type 1 diabetes mellitus (T1DM) after a somewhat unusual presentation. Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides are a relatively rare entity in the general population, and are even less common amongst the pediatric population. Our patient’s chronic history of vague and systemic symptoms paired with social and environmental stressors contributed to her convoluted picture and late diagnosis. In addition, her T1DM adds an interesting element to her case, begging the question of whether her propensity for autoimmune conditions played a role in the development of this disease. With this case, we hope to increase clinician level of suspicion and promote early diagnosis and treatment for future pediatric patients.

scholarly journals A case report of percutaneous direct injection of N-butyl-2-cyanoacrylate (NBCA) to treat a pancreatic duodenal stump leak after a simultaneous pancreas and kidney transplantation

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Chisato Shirakawa ◽  
Masaaki Watanabe ◽  
Tsuyoshi Shimamura ◽  
Yasuyuki Koshizuka ◽  
Norio Kawamura ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Kidney Transplantation ◽  
Type 1 Diabetes Mellitus ◽  
Direct Injection ◽  
Duodenal Stump ◽  
Bladder Drainage ◽  
History Of ◽  
Pancreas Graft

Abstract Background Simultaneous pancreas and kidney transplantation (SPK) is a treatment option for patients with end-stage renal disease due to type 1 diabetes mellitus. We report a patient with a refractory fistula due to leakage from the duodenal stump of the pancreas graft after an SPK with bladder drainage who was successfully treated with a percutaneous direct injection of N-butyl-2-cyanoacrylate (NBCA). Case presentation A 60-year-old female with a 33-year history of type 1 diabetes mellitus and a 10-year history of renal replacement therapy underwent an SPK in 2015. At the time of transplantation, an abdominal aortic aneurysm with a high risk of rupture was treated by a Y-graft replacement prior to the SPK. Bladder drainage of the pancreas graft was chosen to avoid a vessel graft infection. The patient’s postoperative course was uneventful. The patient was discharged on postoperative day 93 with good-functioning pancreas and kidney grafts. One and a half years after the operation, the patient was found to have acute graft pancreatitis and a leak from the duodenal stump of the pancreas graft due to a paralytic neurogenic bladder. The insertion of an indwelling catheter into the bladder and the endoscopic-guided insertion of a catheter into the graft pancreatic duct through the duodenum/bladder anastomosis did not result in the closure of the fistula. Therefore, NBCA was injected at the site of the leak point using CT-guided technique. The fistula was completely closed immediately after the injection, with no recurrences of leaks. Conclusions A percutaneous direct injection of NBCA is one of the treatment options to treat intractable fistulas.

scholarly journals A case of type 1 diabetes mellitus in an elderly patient with a history of idiopathic portal hypertension.

2003 ◽  
Vol 26 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Toru Hiyoshi ◽  
Nobuo Hisano ◽  
Fumito Akasu ◽  
Michiyasu Yoshitsugu ◽  
Tamiko Takemura ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Elderly Patient ◽  
Type 1 Diabetes ◽  
Portal Hypertension ◽  
Type 1 Diabetes Mellitus ◽  
Idiopathic Portal Hypertension ◽  
History Of

scholarly journals Masked Hypertension in Adolescents with Type 1 Diabetes Mellitus: An Exploratory Study

2021 ◽  
pp. 1-5
Author(s):  
Bachar Afandi ◽  
Bassam Bernieh ◽  
Sana Roubi ◽  
Juma Al Kaabi
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Large Scale ◽  
Masked Hypertension ◽  
Diabetes Clinic ◽  
Early Evaluation ◽  
Retinal Examination ◽  
History Of

<b><i>Introduction:</i></b> Masked hypertension (MHTN) is the finding of elevated out-of-office blood pressure (BP) measurement. This is a pilot study to evaluate the prevalence of MHTN in adolescents with type 1 diabetes mellitus (T1DM). <b><i>Patients and Methods:</i></b> Normotensive, adolescents with T1DM were recruited from Tawam Adolescents Diabetes Clinic at Tawam hospital, Al Ain, UAE. They consented to wear the ambulatory BP monitoring (ABPM) device. The heart rate and ambulatory BP were recorded at 15-min intervals for 24 h. Abnormal systolic BP (SBP) and diastolic BP (DBP) were defined as readings above 135 and 85 mm Hg; respectively. <b><i>Results:</i></b> Thirteen patients (10 females) were recruited from “Tawam Adolescents Diabetes Clinic.” The median age was 17 (15–19) years, median BMI 21.4 (14.8–29), and median diabetes duration 9 (3–12) years. All patients had normal retinal examination within the past 12 months. Family history of hypertension (HTN) was present in 6/13 (46%) patients. Office BP measurements revealed a mean DBP ± SD of 72 ± 6.9 mm Hg and mean SBP ± SD116 ± 5.5 mm Hg. The median HbA1c was 8.4% (5.6–13.7) and median GFR 125 mL/min/m<sup>2</sup> (87–134). Two patients had microalbuminuria. Twenty-four hour ABPM revealed elevated SBP and DBP in 12.2 and 5.8% of the values; respectively. Further analysis confirmed MHTN in 4 (30%) patients, nondipping pattern of BP in 5 (38%) patients, and elevated pulse pressure in 8 (61.5%) patients. Only 4 (30%) patients had normal studies. <b><i>Conclusions:</i></b> ABPM uncovered a very high prevalence of MHTN in our patients. Whenever available, ABPM provides an excellent tool for diagnosis and hence early evaluation and management of HTN in adolescents with T1DM. Well-designed large-scale studies are needed to examine the magnitude of MHTN among adolescents with T1DM.

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