scholarly journals Glucose Metabolism and Insulin Action in Alzheimer’s Disease Pathogenesis

10.5772/23138 ◽  
2011 ◽  
Author(s):  
Domenico Bosco ◽  
Massimiliano Plastino ◽  
Antonio Spano ◽  
Caterina Ermio ◽  
Antonietta Fav
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Glucose Metabolism ◽  
Insulin Action ◽  
Disease Pathogenesis

scholarly journals Possible implications of insulin resistance and glucose metabolism in Alzheimer’s disease pathogenesis

2011 ◽  
Vol 15 (9) ◽  
pp. 1807-1821 ◽  
Author(s):  
Domenico Bosco ◽  
Antonietta Fava ◽  
Massimiliano Plastino ◽  
Tiziana Montalcini ◽  
Arturo Pujia
Keyword(s):  
Alzheimer’S Disease ◽  
Insulin Resistance ◽  
Alzheimer's Disease ◽  
Glucose Metabolism ◽  
Disease Pathogenesis

scholarly journals Topographic patterns of white matter hyperintensities are associated with multimodal neuroimaging biomarkers of Alzheimer’s disease

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Malo Gaubert ◽  
Catharina Lange ◽  
Antoine Garnier-Crussard ◽  
Theresa Köbe ◽  
Salma Bougacha ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Glucose Metabolism ◽  
Corpus Callosum ◽  
Gray Matter ◽  
Fdg Pet ◽  
White Matter Hyperintensities ◽  
Gray Matter Volume ◽  
Matter Volume

Abstract Background White matter hyperintensities (WMH) are frequently found in Alzheimer’s disease (AD). Commonly considered as a marker of cerebrovascular disease, regional WMH may be related to pathological hallmarks of AD, including beta-amyloid (Aβ) plaques and neurodegeneration. The aim of this study was to examine the regional distribution of WMH associated with Aβ burden, glucose hypometabolism, and gray matter volume reduction. Methods In a total of 155 participants (IMAP+ cohort) across the cognitive continuum from normal cognition to AD dementia, FLAIR MRI, AV45-PET, FDG-PET, and T1 MRI were acquired. WMH were automatically segmented from FLAIR images. Mean levels of neocortical Aβ deposition (AV45-PET), temporo-parietal glucose metabolism (FDG-PET), and medial-temporal gray matter volume (GMV) were extracted from processed images using established AD meta-signature templates. Associations between AD brain biomarkers and WMH, as assessed in region-of-interest and voxel-wise, were examined, adjusting for age, sex, education, and systolic blood pressure. Results There were no significant associations between global Aβ burden and region-specific WMH. Voxel-wise WMH in the splenium of the corpus callosum correlated with greater Aβ deposition at a more liberal threshold. Region- and voxel-based WMH in the posterior corpus callosum, along with parietal, occipital, and frontal areas, were associated with lower temporo-parietal glucose metabolism. Similarly, lower medial-temporal GMV correlated with WMH in the posterior corpus callosum in addition to parietal, occipital, and fontal areas. Conclusions This study demonstrates that local white matter damage is correlated with multimodal brain biomarkers of AD. Our results highlight modality-specific topographic patterns of WMH, which converged in the posterior white matter. Overall, these cross-sectional findings corroborate associations of regional WMH with AD-typical Aß deposition and neurodegeneration.

scholarly journals Alzheimer’s Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia

2021 ◽  
Vol 22 (7) ◽  
pp. 3330
Author(s):  
Mehdi Eshraghi ◽  
Aida Adlimoghaddam ◽  
Amir Mahmoodzadeh ◽  
Farzaneh Sharifzad ◽  
Hamed Yasavoli-Sharahi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Target ◽  
Neurological Disorder ◽  
Inflammatory Cells ◽  
Disease Pathogenesis ◽  
Current Review ◽  
The Brain ◽  
Comprehensive Discussion

Alzheimer’s disease (AD) is a debilitating neurological disorder, and currently, there is no cure for it. Several pathologic alterations have been described in the brain of AD patients, but the ultimate causative mechanisms of AD are still elusive. The classic hallmarks of AD, including am-yloid plaques (Aβ) and tau tangles (tau), are the most studied features of AD. Unfortunately, all the efforts targeting these pathologies have failed to show the desired efficacy in AD patients so far. Neuroinflammation and impaired autophagy are two other main known pathologies in AD. It has been reported that these pathologies exist in AD brain long before the emergence of any clinical manifestation of AD. Microglia are the main inflammatory cells in the brain and are considered by many researchers as the next hope for finding a viable therapeutic target in AD. Interestingly, it appears that the autophagy and mitophagy are also changed in these cells in AD. Inside the cells, autophagy and inflammation interact in a bidirectional manner. In the current review, we briefly discussed an overview on autophagy and mitophagy in AD and then provided a comprehensive discussion on the role of these pathways in microglia and their involvement in AD pathogenesis.

The bile acid TUDCA improves glucose metabolism in streptozotocin-induced Alzheimer's disease mice model

2021 ◽  
Vol 521 ◽  
pp. 111116
Author(s):  
Lucas Zangerolamo ◽  
Jean F. Vettorazzi ◽  
Carina Solon ◽  
Gabriela A. Bronczek ◽  
Daiane F. Engel ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Bile Acid ◽  
Glucose Metabolism ◽  
Mice Model

scholarly journals Genetic Ablation of Apolipoprotein A-IV Accelerates Alzheimer's Disease Pathogenesis in a Mouse Model

2011 ◽  
Vol 178 (3) ◽  
pp. 1298-1308 ◽  
Author(s):  
Yujie Cui ◽  
Mingwei Huang ◽  
Yingbo He ◽  
Shuyan Zhang ◽  
Yongzhang Luo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Disease Pathogenesis ◽  
Genetic Ablation ◽  
Apolipoprotein A

Brain Glucose Metabolism in Alzheimer’s Disease

1994 ◽  
Vol 308 (3) ◽  
pp. 141-144 ◽  
Author(s):  
Russell Swerdlow ◽  
David L. Marcus ◽  
Jaime Landman ◽  
David Kooby ◽  
William Frey ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Glucose Metabolism ◽  
Brain Glucose ◽  
Brain Glucose Metabolism

Impact of PLCG2 expression on Microglial Biology and Disease Pathogenesis in Alzheimer’s Disease

2021 ◽  
Vol 17 (S2) ◽  
Author(s):  
Andy Po‐Yi Tsai ◽  
Peter Bor‐Chian Lin ◽  
Chuanpeng Dong ◽  
Miguel Moutinho ◽  
Yunlong Liu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Pathogenesis
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