scholarly journals Anti-Angiogenic Therapy for Malignant Glioma: Insights and Future Directions

10.5772/23021 ◽  
2011 ◽  
Author(s):  
Paula Province ◽  
Xiaosi Han ◽  
L. Burt ◽  
Hassan M.
Keyword(s):  
Malignant Glioma ◽  
Future Directions ◽  
Angiogenic Therapy

Immunotherapy for Malignant Glioma: Current Status and Future Directions

2020 ◽  
Vol 41 (2) ◽  
pp. 123-138 ◽  
Author(s):  
Hongxiang Wang ◽  
Tao Xu ◽  
Qilin Huang ◽  
Weilin Jin ◽  
Juxiang Chen
Keyword(s):  
Malignant Glioma ◽  
Current Status ◽  
Future Directions

An exploratory survival analysis of anti-angiogenic therapy for recurrent malignant glioma

2008 ◽  
Vol 92 (2) ◽  
pp. 149-155 ◽  
Author(s):  
Andrew D. Norden ◽  
Jan Drappatz ◽  
Alona Muzikansky ◽  
Karly David ◽  
Mary Gerard ◽  
...  
Keyword(s):  
Survival Analysis ◽  
Malignant Glioma ◽  
Recurrent Malignant Glioma ◽  
Angiogenic Therapy

scholarly journals Antiangiogenic Therapy and Mechanisms of Tumor Resistance in Malignant Glioma

2010 ◽  
Vol 2010 ◽  
pp. 1-16 ◽  
Author(s):  
Ruman Rahman ◽  
Stuart Smith ◽  
Cheryl Rahman ◽  
Richard Grundy
Keyword(s):  
Malignant Glioma ◽  
Antiangiogenic Therapy ◽  
Malignant Gliomas ◽  
Tube Formation ◽  
Endothelial Cell Proliferation ◽  
Vegf Receptor ◽  
Tumor Resistance ◽  
Angiogenic Therapy ◽  
Dismal Prognosis ◽  
Receptor Signal

Despite advances in surgery, radiation therapy, and chemotherapeutics, patients with malignant glioma have a dismal prognosis. The formations of aberrant tumour vasculature and glioma cell invasion are major obstacles for effective treatment. Angiogenesis is a key event in the progression of malignant gliomas, a process involving endothelial cell proliferation, migration, reorganization of extracellular matrix and tube formation. Such processes are regulated by the homeostatic balance between proangiogenic and antiangiogenic factors, most notably vascular endothelial growth factors (VEGFs) produced by glioma cells. Current strategies targeting VEGF-VEGF receptor signal transduction pathways, though effective in normalizing abnormal tumor vasculature, eventually result in tumor resistance whereby a highly infiltrative and invasive phenotype may be adopted. Here we review recent anti-angiogenic therapy for malignant glioma and highlight implantable devices and nano/microparticles as next-generation methods for chemotherapeutic delivery. Intrinsic and adaptive modes of glioma resistance to anti-angiogenic therapy will be discussed with particular focus on the glioma stem cell paradigm.

scholarly journals Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions

Angiogenesis ◽  
2014 ◽  
Vol 17 (3) ◽  
pp. 471-494 ◽  
Author(s):  
Naveen S. Vasudev ◽  
Andrew R. Reynolds
Keyword(s):  
Future Directions ◽  
Angiogenic Therapy

Radiologic response assessment during anti-angiogenic therapy of malignant glioma: a case report

2010 ◽  
Vol 3 (S3) ◽  
pp. 28-29 ◽  
Author(s):  
M. Nowosielski ◽  
M. Hutterer ◽  
D. Putzer ◽  
G. Stockhammer ◽  
W. Recheis ◽  
...  
Keyword(s):  
Case Report ◽  
Malignant Glioma ◽  
Response Assessment ◽  
Angiogenic Therapy

scholarly journals P03.08 Pathological Analysis of Xenografts with Malignant Glioma After Anti-angiogenic Therapy

2017 ◽  
Vol 19 (suppl_3) ◽  
pp. iii34-iii34
Author(s):  
J. Ishida ◽  
K. Kurozumi ◽  
T. Ichikawa ◽  
T. Shimizu ◽  
Y. Otani ◽  
...  
Keyword(s):  
Malignant Glioma ◽  
Angiogenic Therapy ◽  
Pathological Analysis

The Emerging Role of Anti-Angiogenic Therapy for Malignant Glioma†

2008 ◽  
Vol 9 (1) ◽  
pp. 1-22 ◽  
Author(s):  
David A. Reardon ◽  
Annick Desjardins ◽  
Jeremy N. Rich ◽  
James J. Vredenburgh
Keyword(s):  
Malignant Glioma ◽  
Angiogenic Therapy

scholarly journals Current status and future directions of anti-angiogenic therapy for gliomas

2015 ◽  
Vol 18 (3) ◽  
pp. 315-328 ◽  
Author(s):  
Wolfgang Wick ◽  
Michael Platten ◽  
Antje Wick ◽  
Anne Hertenstein ◽  
Alexander Radbruch ◽  
...  
Keyword(s):  
Current Status ◽  
Future Directions ◽  
Angiogenic Therapy

Immunotherapy for malignant glioma: current approaches and future directions

2005 ◽  
Vol 27 (7) ◽  
pp. 703-716 ◽  
Author(s):  
Christian W. Sikorski ◽  
Maciej S. Lesniak
Keyword(s):  
Malignant Glioma ◽  
Future Directions
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