scholarly journals The Development of Encephalitis Following Tick-Borne Encephalitis Virus Infection in a Mouse Model

10.5772/22881 ◽  
2011 ◽  
Author(s):  
Daisuke Hayasaka
Keyword(s):  
Virus Infection ◽  
Mouse Model ◽  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus

scholarly journals A Cluster of Fatal Tick-borne Encephalitis Virus Infection in Organ Transplant Setting

2017 ◽  
Vol 215 (6) ◽  
pp. 896-901 ◽  
Author(s):  
Dariusz Lipowski ◽  
Marta Popiel ◽  
Karol Perlejewski ◽  
Shota Nakamura ◽  
Iwona Bukowska-Ośko ◽  
...  
Keyword(s):  
Virus Infection ◽  
Organ Transplant ◽  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus

scholarly journals Development of an ELISA system for tick-borne encephalitis virus infection in rodents

2011 ◽  
Vol 55 (2) ◽  
pp. 100-107 ◽  
Author(s):  
Ayae Ikawa-Yoshida ◽  
Kentaro Yoshii ◽  
Kazue Kuwahara ◽  
Mayumi Obara ◽  
Hiroaki Kariwa ◽  
...  
Keyword(s):  
Virus Infection ◽  
Encephalitis Virus ◽  
Elisa System ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus

scholarly journals IgG Avidity: an Important Serologic Marker for the Diagnosis of Tick-Borne Encephalitis Virus Infection

2016 ◽  
Vol 65 (1) ◽  
pp. 119-121 ◽  
Author(s):  
Tatjana Vilibic-Cavlek ◽  
Ljubo Barbic ◽  
Vladimir Stevanovic ◽  
Goranka Petrovic ◽  
Gordana Mlinaric-Galinovic
Keyword(s):  
Virus Infection ◽  
Encephalitis Virus ◽  
Serologic Marker ◽  
Igg Avidity ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus

scholarly journals Tick-borne encephalitis virus infection in humans

2016 ◽  
Vol 69 (3-4) ◽  
pp. 93-98 ◽  
Author(s):  
Ivana Hrnjakovic-Cvjetkovic ◽  
Dejan Cvjetkovic ◽  
Aleksandra Patic ◽  
Jelena Radovanov ◽  
Gordana Kovacevic ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Virus Infection ◽  
Severe Disease ◽  
Central Nervous System Infection ◽  
Encephalitis Virus ◽  
Serological Tests ◽  
Worldwide Distribution ◽  
Tick Borne Encephalitis ◽  
Endemic Areas ◽  
Tick Borne Encephalitis Virus

Introduction. Tick-borne meningoencephalitis virus is a flavivirus that causes the most important vector-borne central nervous system infection in many countries of Europe and Asia. There are three subtypes of tick-borne encephalitis virus: European, Siberian and the Far-Eastern subtype. Transmission. In endemic areas, the virus remains in transmissive cycles between Ixodes ticks and small rodents. Clinical picture. In most cases (70?98%) infection goes asymptomatically. In about one-third of meningitis cases, meningoencephalitis or meningomyelitis is developed. Postencephalytic syndrome may be the complication of the infection, presenting with neurological symptoms. Diagnosis. Etiologic diagnosis of tick-borne meningoencephalitis is only made on basis of laboratory analyses. Reverse transcription-polymerase chain reaction is used for determining the presence of virus in the blood and cerebrospinal fluid. Antibodies in blood and cerebrospinal fluid can be detected by serological tests. Prevention. The most efficient way to control this potentially severe disease with possible serious long-term consequences is vaccination. It should be recommended to persons who live or travel to endemic areas. Conclusion. In Serbia, tick-borne encephalitis virus infection belongs to the list of reportable diseases; however, there are no reported cases because the diagnostics is not performed routinely. We believe that the significance of this zoonosis must be examined in our country and some of its parts because of preliminary positive serological findings found out in Vojvodina as well as because of reported cases in neighboring countries such as Hungary and Croatia and its worldwide distribution.

scholarly journals Tick-Borne Encephalitis Virus Vaccine-Induced Human Antibodies Mediate Negligible Enhancement of Zika Virus Infection In Vitro and in a Mouse Model

mSphere ◽  
2018 ◽  
Vol 3 (1) ◽  
Author(s):  
James Duehr ◽  
Silviana Lee ◽  
Gursewak Singh ◽  
Gregory A. Foster ◽  
David Krysztof ◽  
...  
Keyword(s):  
Mouse Model ◽  
Dengue Virus ◽  
Human Plasma ◽  
Mouse Models ◽  
Zika Virus ◽  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus

ABSTRACT Recent reports in the scientific literature have suggested that anti-dengue virus (DENV) and anti-West Nile virus (WNV) immunity exacerbates Zika virus (ZIKV) pathogenesis in vitro and in vivo in mouse models. Large populations of immune individuals exist for a related flavivirus (tick-borne encephalitis virus [TBEV]), due to large-scale vaccination campaigns and endemic circulation throughout most of northern Europe and the southern Russian Federation. As a result, the question of whether anti-TBEV immunity can affect Zika virus pathogenesis is a pertinent one. For this study, we obtained 50 serum samples from individuals vaccinated with the TBEV vaccine FSME-IMMUN (Central European/Neudörfl strain) and evaluated their enhancement capacity in vitro using K562 human myeloid cells expressing CD32 and in vivo using a mouse model of ZIKV pathogenesis. Among the 50 TBEV vaccinee samples evaluated, 29 had detectable reactivity against ZIKV envelope (E) protein by enzyme-linked immunosorbent assay (ELISA), and 36 showed enhancement of ZIKV infection in vitro. A pool of the most highly reacting and enhanced samples resulted in no significant change in the morbidity/mortality of ZIKV disease in immunocompromised Stat2−/− mice. Our results suggest that humoral immunity against TBEV is unlikely to enhance Zika virus pathogenesis in humans. No clinical reports indicating that TBEV vaccinees experiencing enhanced ZIKV disease have been published so far, and though the epidemiological data are sparse, our findings suggest that there is little reason for concern. This study also displays a clear relationship between the phylogenetic distance between two flaviviruses and their capacity for pathogenic enhancement. IMPORTANCE The relationship between serial infections of two different serotypes of dengue virus and more severe disease courses is well-documented in the literature, driven by so-called antibody-dependent enhancement (ADE). Recently, studies have shown the possibility of ADE in cells exposed to anti-DENV human plasma and then infected with ZIKV and also in mouse models of ZIKV pathogenesis after passive transfer of anti-DENV human plasma. In this study, we evaluated the extent to which this phenomenon occurs using sera from individuals immunized against tick-borne encephalitis virus (TBEV). This is highly relevant, since large proportions of the European population are vaccinated against TBEV or otherwise seropositive.

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