scholarly journals Immunological Analysis of Liver Diseases with Liver Biopsy Specimens

Liver Biopsy ◽  
10.5772/22606 ◽  
2011 ◽  
Author(s):  
Kazuto Tajiri ◽  
Yukihiro Shimizu
Keyword(s):  
Liver Biopsy ◽  
Liver Diseases ◽  
Immunological Analysis ◽  
Biopsy Specimens

Stereology of liver biopsy specimens from patients with cirrhosis

1984 ◽  
Vol 42 ◽  
pp. 674-675
Author(s):  
J. W. Ryoo ◽  
R. J. Buschmann
Keyword(s):  
Liver Cirrhosis ◽  
Liver Biopsy ◽  
Liver Diseases ◽  
Cirrhotic Liver ◽  
Ultrastructural Morphometry ◽  
Diagnosis And Management ◽  
Biopsy Specimens ◽  
Invaluable Tool ◽  
Histologic Evaluation ◽  
Morphometric Evaluation

Histologic evaluation of liver biopsy specimens is an invaluable tool for the diagnosis and management of liver diseases. Ultrastructural evaluation of biopsy specimens, however, has been limited and qualitative in nature. Many of the ultrastuructural changes associated with liver diseases, particularly the different stages of liver diseases like liver cirrhosis, are likely quantitative and thereby detectable morphometrically. Difficulties, however, arise from the variabilities attributable to a patient's age, to the time of biopsy, to known intralobular differences, and to drugs that the patients may be taking. In order to test the feasibility of ultrastructural morphometry in the study of liver cirrhosis notwithstanding these uncontrollable variables, we carried out a morphometric evaluation of human cirrhotic liver.

Ultrastructural Changes Associated with Alcoholic Hyalin in Hepatocytes and Biliary Epithelial Cells

1971 ◽  
Vol 29 ◽  
pp. 572-573
Author(s):  
Odell T. Minick ◽  
Hidejiro Yokoo ◽  
Fawzia Batti
Keyword(s):  
Endoplasmic Reticulum ◽  
Epithelial Cells ◽  
Liver Biopsy ◽  
Alcoholic Hepatitis ◽  
Ultrastructural Changes ◽  
Main Mass ◽  
Biliary Epithelial Cells ◽  
Biopsy Specimens ◽  
Alcoholic Hyalin

To learn more of the nature and origin of alcoholic hyalin (AH), 15 liver biopsy specimens from patients with alcoholic hepatitis were studied in detail.AH was found not only in hepatocytes but also in ductular cells (Figs. 1 and 2), although in the latter location only rarely. The bulk of AH consisted of a randomly oriented network of closely packed filaments measuring about 150 Å in width. Bundles of filaments smaller in diameter (40-90 Å) were observed along the periphery of the main mass (Fig. 1), often surrounding it in a rim-like fashion. Fine filaments were also found close to the nucleus in both hepatocytes and biliary epithelial cells, the latter even though characteristic AH was not present (Figs. 3 and 4). Dispersed among the larger filaments were glycogen, RNA particles and profiles of endoplasmic reticulum. Dilated cisternae of endoplasmic reticulum were often conspicuous around the periphery of the AH mass. A limiting membrane was not observed.

scholarly journals Diagnostic Performance of Noninvasive Methods for Liver Biopsy by Fibroscan in Pediatric

2021 ◽  
Vol 11 (01) ◽  
pp. e55-e59
Author(s):  
Farzaneh Motamed ◽  
Ghobad Heidari ◽  
Bita Heirati ◽  
Parisa Rahmani
Keyword(s):  
Liver Biopsy ◽  
Liver Diseases ◽  
Storage Disease ◽  
Sampling Error ◽  
Medical Center ◽  
Glycogen Storage ◽  
Chronic Liver ◽  
Noninvasive Methods ◽  
Function Test ◽  
Diagnostic Modalities

AbstractLiver biopsy is the gold standard for the diagnosis and management of various liver diseases; however, noninvasive diagnostic modalities may help prevent adverse effects of anesthesia, prolonged hospitalization, sampling error, and other serious complications, particularly in pediatric patients. The aim of this study is to compare the results of liver biopsy and fibroscan in children with chronic liver diseases. All patients presenting chronic liver disease admitted in the ward or clinic of Tehran's Children Medical Center were enrolled in the study. Required laboratory tests were performed to diagnose the disease, followed by elastography using fibroscan 402 (M-probe) Echosens machine and liver biopsy using Menghini technique. Samples were scored by using METAVIR scoring system. Thirty-two patients were reported (68.8%, female) with autoimmune hepatitis (18.8%), Wilson disease (12.5%), and glycogen storage disease (12.5%). The most common pathologic stage and fibroscan result was stage III and F0 (46.9%), respectively. Association between pathology and fibroscan results was not significant. Nonetheless, age and diagnosis, age and Fibroscan score, and pathology and liver function test were significantly associated with each other. Fibroscan cannot be used as an alternative to liver biopsy; however, it can be a useful accessory tool.

scholarly journals Novel Laboratory Tests in Assessment of Liver Function in Acute and Chronic Liver Diseases

2009 ◽  
Vol 63 (4-5) ◽  
pp. 228-233
Author(s):  
Ludmila Vīksna ◽  
Jāzeps Keišs ◽  
Artūrs Sočņevs ◽  
Baiba Rozentāle ◽  
Māra Pilmane ◽  
...  
Keyword(s):  
Liver Function ◽  
Liver Biopsy ◽  
Liver Diseases ◽  
Laboratory Tests ◽  
Serum Markers ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Noninvasive Methods ◽  
Disease Evolution ◽  
Prognostic Accuracy

Novel Laboratory Tests in Assessment of Liver Function in Acute and Chronic Liver Diseases Liver biopsy in clinical practice has been widely used for the diagnosis and management of patients with liver diseases, particularly, with chronic liver diseases. However, liver biopsy is an invasive method with potential complications, sampling and interpretation errors. Therefore, noninvasive tests are being developed and introduced to replace liver biopsy. The aim of the present study was to identify the new noninvasive methods to be used for the assessment of liver structure and function, by use of the appropriate serum surrogate markers and to evaluate the clinical diagnostic and prognostic accuracy of these methods, including immunogenetic methods, in cases of acute and chronic liver diseases. The obtained data showed that serum markers of apoptosis (cytokeratin-18 neoepitope and citochrome c) and fibrosis (hyaluronic acid) should be included in viral and toxic liver damage management algorithms. The punctual identification of immunogenetic factors (HLA class II antigens) may prove to be useful in predicting disease evolution, and in guiding the appropriate therapy for patients with poor prognosis.

Serum Hepatitis C Virus RNA Levels and Histologic Findings in Liver Allografts With Early Recurrent Hepatitis C

2000 ◽  
Vol 124 (11) ◽  
pp. 1623-1627 ◽  
Author(s):  
Young Nyun Park ◽  
Peter Boros ◽  
David Y. Zhang ◽  
Patricia Sheiner ◽  
Leona Kim-Schluger ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Biopsy ◽  
Activity Index ◽  
Hcv Rna ◽  
Recurrent Hepatitis ◽  
Biopsy Specimens ◽  
Histologic Activity Index ◽  
Recurrent Hepatitis C ◽  
Rna Levels

Abstract Background.—Histopathologic features of early recurrent hepatitis C after orthotopic liver transplantation (OLTx) may be modified by immunosuppressive therapy or complicated by other conditions. Hepatitis C virus (HCV) RNA level usually increases after OLTx, but its correlation to histologic findings is not clear. Objective.—To evaluate the histologic findings of early recurrent hepatitis C in liver allografts and its correlation to serum HCV RNA level. Methods.—We studied 14 patients who underwent OLTx for chronic HCV infection. Thirty liver biopsy specimens and HCV RNA levels of 22 corresponding plasma samples obtained during the first 6 months following OLTx were analyzed. The control group (9 patients, 25 biopsy specimens) was chosen at random from patients with chronic liver disease other than HCV who were undergoing OLTx, and all tested negative for HCV RNA by polymerase chain reaction after OLTx. Results.—Statistically significant pathological features of early recurrent HCV infection were the number of acidophilic bodies, piecemeal necrosis, lymphocyte predominance in the portal tracts, and fibrous septum. These findings and histologic activity index scores increased with time after OLTx. The HCV RNA levels determined by branched DNA assay showed no significant correlation with histologic features. However, patients with higher histologic activity index scores tended to have higher RNA levels. Conclusions.—Liver biopsy specimens are helpful for the diagnosis or confirmation of early recurrent hepatitis C in liver allografts, but serial biopsy specimens are sometimes required for definite diagnosis. The HCV RNA levels are usually higher in patients who display signs of more severe liver damage.

scholarly journals Markedly lower follow-up rate after liver biopsy in patients with non-alcoholic fatty liver diseases than those with viral hepatitis in Japan

2011 ◽  
Vol 4 (1) ◽  
Author(s):  
Hidenori Toyoda ◽  
Takashi Kumada ◽  
Seiki Kiriyama ◽  
Makoto Tanikawa ◽  
Yasuhiro Hisanaga ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Fatty Liver ◽  
Viral Hepatitis ◽  
Liver Diseases ◽  
Alcoholic Fatty Liver

Phenotypic and functional characteristics of lymphocytes isolated from liver biopsy specimens from patients with active liver disease

Hepatology ◽  
1992 ◽  
Vol 15 (5) ◽  
pp. 816-823 ◽  
Author(s):  
Kensaku Hata ◽  
David H. van Thiel ◽  
Ronald B. Herberman ◽  
Theresa L. Whiteside
Keyword(s):  
Liver Disease ◽  
Liver Biopsy ◽  
Functional Characteristics ◽  
Biopsy Specimens
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