Recent Advances in Understanding of Alternative Splicing in Neuronal Pathogenesis

Global Approaches to Alternative Splicing and Its Regulation—Recent Advances and Open Questions

Translational Bioinformatics - Transcriptomics and Gene Regulation ◽

10.1007/978-94-017-7450-5_2 ◽

2015 ◽

pp. 37-71 ◽

Cited By ~ 1

Author(s):

Yun-Hua Esther Hsiao ◽

Ashley A. Cass ◽

Jae Hoon Bahn ◽

Xianzhi Lin ◽

Xinshu Xiao

Keyword(s):

Alternative Splicing ◽

Recent Advances ◽

Open Questions

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Recent Advances in High Dispersion Spectroscopy of Globular Cluster Stars

Symposium - International Astronomical Union ◽

10.1017/s0074180900035610 ◽

1988 ◽

Vol 132 ◽

pp. 525-530

Author(s):

Raffaele G. Gratton

Keyword(s):

Globular Cluster ◽

Globular Clusters ◽

High Dispersion ◽

Photographic Material ◽

Recent Advances ◽

Metal Abundances ◽

Ccd Detectors ◽

Major Progress

The use CCD detectors has allowed a major progress in abundance derivations for globular cluster stars in the last years. Abundances deduced from high dispersion spectra now correlates well with other abundance indicators. I discuss some problems concerning the derivation of accurate metal abundances for globular clusters using high dispersion spectra from both the old photographic and the most recent CCD data. The discrepant low abundances found by Cohen (1980), from photographic material for M71 giants, are found to be due to the use of too high microturbulences.

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Chelation-assisted transition metal-catalysed C–H chalcogenylations

Organic Chemistry Frontiers ◽

10.1039/c9qo01497g ◽

2020 ◽

Vol 7 (8) ◽

pp. 1022-1060 ◽

Cited By ~ 7

Author(s):

Wenbo Ma ◽

Nikolaos Kaplaneris ◽

Xinyue Fang ◽

Linghui Gu ◽

Ruhuai Mei ◽

...

Keyword(s):

Transition Metal ◽

Recent Advances ◽

Site Selectivity ◽

Transition Metal Catalyzed ◽

Metal Catalyzed

This review summarizes recent advances in C–S and C–Se formations via transition metal-catalyzed C–H functionalization utilizing directing groups to control the site-selectivity.

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Linking transcription, RNA polymerase II elongation and alternative splicing

Biochemical Journal ◽

10.1042/bcj20200475 ◽

2020 ◽

Vol 477 (16) ◽

pp. 3091-3104 ◽

Cited By ~ 1

Author(s):

Luciana E. Giono ◽

Alberto R. Kornblihtt

Keyword(s):

Gene Expression ◽

Alternative Splicing ◽

Rna Polymerase Ii ◽

Environmental Changes ◽

Transcription Elongation ◽

Single Gene ◽

Regulation Of Gene Expression ◽

Regulation Of Transcription ◽

Stepping Stones ◽

Eukaryotic Transcription

Gene expression is an intricately regulated process that is at the basis of cell differentiation, the maintenance of cell identity and the cellular responses to environmental changes. Alternative splicing, the process by which multiple functionally distinct transcripts are generated from a single gene, is one of the main mechanisms that contribute to expand the coding capacity of genomes and help explain the level of complexity achieved by higher organisms. Eukaryotic transcription is subject to multiple layers of regulation both intrinsic — such as promoter structure — and dynamic, allowing the cell to respond to internal and external signals. Similarly, alternative splicing choices are affected by all of these aspects, mainly through the regulation of transcription elongation, making it a regulatory knob on a par with the regulation of gene expression levels. This review aims to recapitulate some of the history and stepping-stones that led to the paradigms held today about transcription and splicing regulation, with major focus on transcription elongation and its effect on alternative splicing.

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Nucleosome dynamics

Biochemical Society Symposium ◽

10.1042/bss0730109 ◽

2006 ◽

Vol 73 ◽

pp. 109-119 ◽

Cited By ~ 2

Author(s):

Chris Stockdale ◽

Michael Bruno ◽

Helder Ferreira ◽

Elisa Garcia-Wilson ◽

Nicola Wiechens ◽

...

Keyword(s):

High Resolution ◽

Chromatin Structure ◽

Current Knowledge ◽

Dynamic Properties ◽

Structure And Dynamics ◽

Nucleosome Dynamics ◽

Sharp Focus ◽

Recent Advances ◽

Insight Into ◽

Chromatin Structure And Dynamics

In the 30 years since the discovery of the nucleosome, our picture of it has come into sharp focus. The recent high-resolution structures have provided a wealth of insight into the function of the nucleosome, but they are inherently static. Our current knowledge of how nucleosomes can be reconfigured dynamically is at a much earlier stage. Here, recent advances in the understanding of chromatin structure and dynamics are highlighted. The ways in which different modes of nucleosome reconfiguration are likely to influence each other are discussed, and some of the factors likely to regulate the dynamic properties of nucleosomes are considered.

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