scholarly journals L- Myo-Inositol 1-Phosphate Synthase (MIPS) in Chickpea: Gene Duplication and Functional Divergence

10.5772/22435 ◽  
2011 ◽  
Author(s):  
Manoj Majee ◽  
Harmeet Kaur
2004 ◽  
Vol 279 (27) ◽  
pp. 28539-28552 ◽  
Author(s):  
Manoj Majee ◽  
Susmita Maitra ◽  
Krishnarup Ghosh Dastidar ◽  
Sitakanta Pattnaik ◽  
Anirban Chatterjee ◽  
...  

1979 ◽  
Vol 25 (1) ◽  
Author(s):  
Fritz Pittner ◽  
IrinaI. Tovarova ◽  
ElenaYa. Kornitskaya ◽  
AleksanderS. Khokhlov ◽  
Otto Hoffmann-Ostenhof

2021 ◽  
Author(s):  
Stefano Pascarelli ◽  
Paola Laurino

Connecting protein sequence to function is becoming increasingly relevant since high-throughput sequencing studies accumulate large amounts of genomic data. Protein database annotation helps to bridge this gap; however, it is fundamental to understand the mechanisms underlying functional inheritance and divergence. If the homology relationship between proteins is known, can we determine whether the function diverged? In this work, we analyze different possibilities of protein sequence evolution after gene duplication and identify "residue inversions", i.e., sites where the relationship between the ancestry and the functional signal is decoupled. Residues in these sites play a role in functional divergence and could indicate a shift in protein function. We develop a method to recognize residue inversions in a phylogeny and test it on real and simulated datasets. In a dataset built from the Epidermal Growth Factor Receptor (EGFR) sequences found in 88 fish species, we identify 19 positions that went through inversion after gene duplication, mostly located at the ligand-binding extracellular domain.


1987 ◽  
Vol 85 (3) ◽  
pp. 611-614 ◽  
Author(s):  
Jukta Adhikari ◽  
Asima Lahiri Majumder ◽  
Tirtha Jyoti Bhaduri ◽  
Sarmila DasGupta ◽  
Arun Lahiri Majumder

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