scholarly journals Role of Liver Biopsy After Liver Transplantation

10.5772/22163 ◽  
2011 ◽  
Author(s):  
Marco Carbone ◽  
James Neuberger
Keyword(s):  
Liver Transplantation ◽  
Liver Biopsy

The role of liver biopsy in evaluating acute allograft dysfunction following liver transplantation: A clinical histologic correlation of 34 liver transplants

1988 ◽  
Vol 19 (7) ◽  
pp. 835-848 ◽  
Author(s):  
Richard A. Ray ◽  
Klaus J. Lewin ◽  
John Colonna ◽  
Leonard I. Goldstein ◽  
Ronald W. Busuttil
Keyword(s):  
Liver Transplantation ◽  
Liver Biopsy ◽  
Liver Transplants ◽  
Allograft Dysfunction

scholarly journals Role of tissue C4d in differentiation between acute rejection and HCV recurrence after living donor liver transplantation

2020 ◽  
Vol 7 (8) ◽  
pp. 1196
Author(s):  
Zeinab Salah Eldin Hamza Khalil ◽  
Waleed Gad Dandarawy Hassan
Keyword(s):  
Liver Transplantation ◽  
Liver Biopsy ◽  
Acute Rejection ◽  
Positive Predictive Value ◽  
Portal Vein ◽  
Predictive Value ◽  
Pathological Finding ◽  
Specific Marker ◽  
C4d Staining

Background: Liver biopsy represents the gold standard for diagnosis of acute rejection and HCV recurrence after liver transplantation; never the less discrimination can be difficult due to similar display of alterations in liver specimen. Therefore, a specific marker expressed only in rejection but not in HCV recurrence would be a great asset to differentiate between both conditions. The aim of this study was to assess the role of tissue C4d complement fragments in liver biopsy as a marker for differentiating between acute rejection and HCV recurrence in recipients post LDLT.Methods: A case control study on 25 recipients after liver transplantation with the suspicion of either acute rejection or HCV disease recurrence, patients were classified according to pathological finding into two groups, Group 1: patients with acute rejection (n=13), Group 2: patients with HCV recurrence (n=12), The C4d was evaluated by immunohistochemical staining of the formalin-fixed, paraffin-embedded tissue in different liver compartments.Results: C4D staining of all the studied tissue compartments (Sinusoids, portal vein endothelium, hepatic vein endothelium, arterial internal elastic lining, portal stroma, bile ducts) had high specificity (100%) and positive predictive value (100%) in diagnosis of rejection cases except portal vein endothelium. (Specificity 91.7%, positive predictive value 88.9%).Conclusions: Tissue C4d staining was almost present in rejection cases only; further studies on larger cohort are required to stand on standard diagnostic criteria for C4d to be included in diagnosis of acute rejection after liver transplantation as its role in other organ transplantation.

scholarly journals Network pharmacology-based analysis of the role of tacrolimus in liver transplantation

2021 ◽  
Author(s):  
Lijian Chen ◽  
Yuming Peng ◽  
Chunyi Ji ◽  
Miaoxian Yuan ◽  
Qiang Yin
Keyword(s):  
Liver Transplantation ◽  
Network Pharmacology

The role of autonomic dysfunction in predicting 1-year mortality after liver transplantation

2017 ◽  
Vol 37 (8) ◽  
pp. 1239-1248 ◽  
Author(s):  
Kuang-Cheng Chan ◽  
Jia-Rong Yeh ◽  
Wei-Zen Sun
Keyword(s):  
Liver Transplantation ◽  
Autonomic Dysfunction
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