scholarly journals Characterization of Acute-Phase Proteins (Apps)

10.5772/21862 ◽  
2012 ◽  
Author(s):  
Sin Tak ◽  
Ying Chu
Keyword(s):  
Acute Phase ◽  
Acute Phase Proteins

scholarly journals Characterization of acute phase proteins and oxidative stress response to road transportation in the dog

2015 ◽  
Vol 64 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Francesco FAZIO ◽  
Stefania CASELLA ◽  
Claudia GIANNETTO ◽  
Elisabetta GIUDICE ◽  
Giuseppe PICCIONE
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Acute Phase ◽  
Acute Phase Proteins ◽  
Oxidative Stress Response ◽  
Road Transportation ◽  
And Oxidative Stress

Studies on Acute Phase Proteins of Rat Serum. I. Isolation and Partial Characterization of an α1-Acid Glycoprotein and an α2-Macroglobulin

1972 ◽  
Vol 50 (8) ◽  
pp. 856-870 ◽  
Author(s):  
J. C. Jamieson ◽  
A. D. Friesen ◽  
F. E. Ashton ◽  
B. Chou
Keyword(s):  
Molecular Weight ◽  
Physical Properties ◽  
Acute Phase ◽  
Isoelectric Point ◽  
Acute Phase Proteins ◽  
Partial Characterization ◽  
Rat Serum ◽  
Acid Glycoprotein ◽  
Α2 Macroglobulin

An α1-acid glycoprotein and an α2-macroglobulin were isolated from serum from rats suffering from experimentally induced inflammation for 48 h. The proteins were characterized electrophoretically and immunologically and their carbohydrate compositions and some physical properties determined. The α1-acid glycoprotein contained 34.1% carbohydrate, had an isoelectric point of 2.95, and a molecular weight of 43 000. The α2-macroglobulin contained 15.9% carbohydrate, had an isoelectric point of 4.60, and a molecular weight of about 800 000. The properties of the two proteins are compared with those of similar proteins isolated from rats and other species.

Keratins 8/18 represent type II acute-phase proteins which are differentially regulated in human liver disease

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
N Güldiken ◽  
V Usachov ◽  
K Levada ◽  
M Ziol ◽  
P Nahon ◽  
...  
Keyword(s):  
Liver Disease ◽  
Acute Phase ◽  
Human Liver ◽  
Acute Phase Proteins ◽  
Type Ii ◽  
Human Liver Disease

scholarly journals Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study

Critical Care ◽  
2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Pavan K. Bhatraju ◽  
Eric D. Morrell ◽  
Leila Zelnick ◽  
Neha A. Sathe ◽  
Xin-Ya Chai ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Epithelial Cell ◽  
Acute Phase ◽  
Cell Injury ◽  
Acute Phase Proteins ◽  
Invasive Mechanical Ventilation ◽  
Icu Patients ◽  
Icu Admission ◽  
Amyloid A ◽  
Epithelial Cell Injury

Abstract Background Analyses of blood biomarkers involved in the host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection can reveal distinct biological pathways and inform development and testing of therapeutics for COVID-19. Our objective was to evaluate host endothelial, epithelial and inflammatory biomarkers in COVID-19. Methods We prospectively enrolled 171 ICU patients, including 78 (46%) patients positive and 93 (54%) negative for SARS-CoV-2 infection from April to September, 2020. We compared 22 plasma biomarkers in blood collected within 24 h and 3 days after ICU admission. Results In critically ill COVID-19 and non-COVID-19 patients, the most common ICU admission diagnoses were respiratory failure or pneumonia, followed by sepsis and other diagnoses. Similar proportions of patients in both groups received invasive mechanical ventilation at the time of study enrollment. COVID-19 and non-COVID-19 patients had similar rates of acute respiratory distress syndrome, severe acute kidney injury, and in-hospital mortality. While concentrations of interleukin 6 and 8 were not different between groups, markers of epithelial cell injury (soluble receptor for advanced glycation end products, sRAGE) and acute phase proteins (serum amyloid A, SAA) were significantly higher in COVID-19 compared to non-COVID-19, adjusting for demographics and APACHE III scores. In contrast, angiopoietin 2:1 (Ang-2:1 ratio) and soluble tumor necrosis factor receptor 1 (sTNFR-1), markers of endothelial dysfunction and inflammation, were significantly lower in COVID-19 (p < 0.002). Ang-2:1 ratio and SAA were associated with mortality only in non-COVID-19 patients. Conclusions These studies demonstrate that, unlike other well-studied causes of critical illness, endothelial dysfunction may not be characteristic of severe COVID-19 early after ICU admission. Pathways resulting in elaboration of acute phase proteins and inducing epithelial cell injury may be promising targets for therapeutics in COVID-19.

scholarly journals Effects of Stocking and Transport Conditions on Physicochemical Properties of Meat and Acute-Phase Proteins in Cattle

Foods ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 252
Author(s):  
Ahmed A. Abubakar ◽  
Idrus Zulkifli ◽  
Yong M. Goh ◽  
Ubedullah Kaka ◽  
Azad B. Sabow ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Acute Phase ◽  
Acute Phase Proteins ◽  
Stocking Density ◽  
Road Transport ◽  
Long Distance ◽  
Amyloid A ◽  
Tropical Conditions ◽  
Meat Samples ◽  
Water Holding

This study’s objective was to evaluate the effects of distance and stocking density on physicochemical properties and oxidative stability of meat and acute-phase proteins in Brahman crossbred cattle transported by road under hot and humid tropical conditions. Sixty Brahman crossbred heifers were subjected to road transport from a cattle feedlot farm located in Universiti Putra Malaysia (UPM), Serdang, to a commercial ruminant abattoir in Shah Alam, Selangor. Animals were assigned to long and short distances and high, medium, and low stocking densities. The results revealed that the intensity of response significantly increased in meat samples from animals subjected to long-distance transportation and higher stocking density. Alpha-1-acid glycoprotein and serum amyloid-A values increased considerably and were different from the baseline values recorded at preload. In conclusion, the current results revealed that the color, pH, shear force values, water holding capacity (WHC), glycogen level, and malondilaldehyde assay (MDA) concentrations in meat and acute-phase proteins (APP) were affected by both distances and stocking densities, as evidenced by the significant changes recorded from the parameters above.

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