scholarly journals Highly Sensitive SPR Biosensor Based on Nanoimprinting Technology

10.5772/21481 ◽  
2011 ◽  
Author(s):  
Satoshi Fujita ◽  
Takeo Nishikaw
Keyword(s):  
Spr Biosensor ◽  
Highly Sensitive

Highly sensitive PCF-SPR biosensor for hyperthermia temperature monitoring

2018 ◽  
Vol 47 (3) ◽  
pp. 288-294 ◽  
Author(s):  
Famei Wang ◽  
Zhijie Sun ◽  
Tao Sun ◽  
Chao Liu ◽  
Paul K. Chu ◽  
...  
Keyword(s):  
Temperature Monitoring ◽  
Spr Biosensor ◽  
Highly Sensitive

Highly sensitive antimonene based SPR biosensor for miRNA detection

2020 ◽  
Vol 28 ◽  
pp. 1776-1780
Author(s):  
Maneesh Kumar Singh ◽  
Sarika Pal ◽  
Y.K. Prajapati ◽  
J.P. Saini
Keyword(s):  
Spr Biosensor ◽  
Highly Sensitive ◽  
Mirna Detection

scholarly journals Design and Numerical Analysis of a Graphene-Coated SPR Biosensor for Rapid Detection of the Novel Coronavirus

Sensors ◽  
2021 ◽  
Vol 21 (10) ◽  
pp. 3491
Author(s):  
Tarik Bin Abdul Akib ◽  
Samia Ferdous Mou ◽  
Md. Motiur Rahman ◽  
Md. Masud Rana ◽  
Md. Rabiul Islam ◽  
...  
Keyword(s):  
Refractive Index ◽  
Surface Plasmon ◽  
Rapid Detection ◽  
Detection Sensitivity ◽  
Spike Protein ◽  
Detection Accuracy ◽  
The Novel ◽  
Spr Biosensor ◽  
Highly Sensitive ◽  
Novel Coronavirus

In this paper, a highly sensitive graphene-based multiple-layer (BK7/Au/PtSe2/Graphene) coated surface plasmon resonance (SPR) biosensor is proposed for the rapid detection of the novel Coronavirus (COVID-19). The proposed sensor was modeled on the basis of the total internal reflection (TIR) technique for real-time detection of ligand-analyte immobilization in the sensing region. The refractive index (RI) of the sensing region is changed due to the interaction of different concentrations of the ligand-analyte, thus impacting surface plasmon polaritons (SPPs) excitation of the multi-layer sensor interface. The performance of the proposed sensor was numerically investigated by using the transfer matrix method (TMM) and the finite-difference time-domain (FDTD) method. The proposed SPR biosensor provides fast and accurate early-stage diagnosis of the COVID-19 virus, which is crucial in limiting the spread of the pandemic. In addition, the performance of the proposed sensor was investigated numerically with different ligand-analytes: (i) the monoclonal antibodies (mAbs) as ligand and the COVID-19 virus spike receptor-binding domain (RBD) as analyte, (ii) the virus spike RBD as ligand and the virus anti-spike protein (IgM, IgG) as analyte and (iii) the specific probe as ligand and the COVID-19 virus single-standard ribonucleic acid (RNA) as analyte. After the investigation, the sensitivity of the proposed sensor was found to provide 183.33°/refractive index unit (RIU) in SPR angle (θSPR) and 833.33THz/RIU in SPR frequency (SPRF) for detection of the COVID-19 virus spike RBD; the sensitivity obtained 153.85°/RIU in SPR angle and 726.50THz/RIU in SPRF for detection of the anti-spike protein, and finally, the sensitivity obtained 140.35°/RIU in SPR angle and 500THz/RIU in SPRF for detection of viral RNA. It was observed that whole virus spike RBD detection sensitivity is higher than that of the other two detection processes. Highly sensitive two-dimensional (2D) materials were used to achieve significant enhancement in the Goos-Hänchen (GH) shift detection sensitivity and plasmonic properties of the conventional SPR sensor. The proposed sensor successfully senses the COVID-19 virus and offers additional (1 + 0.55) × L times sensitivity owing to the added graphene layers. Besides, the performance of the proposed sensor was analyzed based on detection accuracy (DA), the figure of merit (FOM), signal-noise ratio (SNR), and quality factor (QF). Based on its performance analysis, it is expected that the proposed sensor may reduce lengthy procedures, false positive results, and clinical costs, compared to traditional sensors. The performance of the proposed sensor model was checked using the TMM algorithm and validated by the FDTD technique.

A highly sensitive SPR biosensor based on a graphene oxide sheet modified with gold bipyramids, and its application to an immunoassay for rabbit IgG

2015 ◽  
Vol 182 (9-10) ◽  
pp. 1739-1746 ◽  
Author(s):  
Qiong Wu ◽  
Daqian Song ◽  
Di Zhang ◽  
Hua Zhang ◽  
Yaying Ding ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Graphene Oxide Sheet ◽  
Spr Biosensor ◽  
Rabbit Igg ◽  
Highly Sensitive

scholarly journals Hybrid Heterostructures for SPR Biosensor

2020 ◽  
Author(s):  
Md. Shamim Anower ◽  
Md. Mahabubur Rahman ◽  
M. Saifur Rahman
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Transition Metal Dichalcogenides ◽  
Medical Diagnostics ◽  
Hybrid Structures ◽  
Spr Biosensor ◽  
Highly Sensitive ◽  
Metal Dichalcogenides ◽  
Comparison Table ◽  
Potential Use

Surface plasmon resonance (SPR) based biosensors have been enormously studied in the last decade for their better sensitivity. In recent years hybrid heterostructures are getting popularity to implement these SPR biosensors for their superior sensing capability. This chapter demonstrates the details of SPR technology with two recently studied prism-based hybrid heterostructures. These heterostructures are made up of conventional SPR biosensors with two additional layers of recently invented transition metal dichalcogenides, platinum di-selenide (PtSe2), and highly sensitive 2D material, tungsten di-sulfide (WS2). Angular interrogation method is discussed to investigate the sensing capabilities of the sensors which prove the superiority of the Ag-PtSe2-WS2 structure. The sensing capability of this structure has been found at least 1.67 times higher than that of the conventional non-hybrid structures, respectively, with comparable FOM and QF. A comparison table has been provided at the end of this chapter which also shows the impressive performance of the hybrid heterostructures for SPR biosensors. Proper demonstration with a suitable example of this chapter will emphasize the potential use of hybrid heterostructure based SPR biosensors in prospective medical diagnostics and biomedical detection applications.

Modeling of a highly sensitive MoS2-Graphene hybrid based fiber optic SPR biosensor for sensing DNA hybridization

Optik ◽  
2017 ◽  
Vol 140 ◽  
pp. 989-997 ◽  
Author(s):  
M. Saifur Rahman ◽  
M.S. Anower ◽  
Md. Khalilur Rahman ◽  
Md. Rabiul Hasan ◽  
Md. Biplob Hossain ◽  
...  
Keyword(s):  
Dna Hybridization ◽  
Fiber Optic ◽  
Spr Biosensor ◽  
Highly Sensitive

Real-time detection of α-thrombin binding to single-strand DNA aptamers by a highly sensitive Si-based waveguide SPR biosensor

2012 ◽  
Author(s):  
Chi-Chieh Huang ◽  
Hsin-Feng Hsu ◽  
Sz-Hau Chen ◽  
Kun-Yu Tsai ◽  
Yang-Tung Huang ◽  
...  
Keyword(s):  
Real Time ◽  
Single Strand ◽  
Dna Aptamers ◽  
Spr Biosensor ◽  
Highly Sensitive ◽  
Real Time Detection
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