scholarly journals The Blood-Brain Barrier in Brain Tumours

10.5772/21465 ◽  
2011 ◽  
Author(s):  
Susan Noell ◽  
Karen Wolburg-Buchholz ◽  
Andreas F. ◽  
Hartwig Wolburg ◽  
Petra Fallier-Becker
Keyword(s):  
Blood Brain Barrier ◽  
Brain Tumours ◽  
Brain Barrier ◽  
Blood Brain

Modulation of the blood–brain barrier in oncology: therapeutic opportunities for the treatment of brain tumours?

2004 ◽  
Vol 30 (5) ◽  
pp. 415-423 ◽  
Author(s):  
E.Marleen Kemper ◽  
Willem Boogerd ◽  
Ingrid Thuis ◽  
Jos H Beijnen ◽  
Olaf van Tellingen
Keyword(s):  
Blood Brain Barrier ◽  
Brain Tumours ◽  
Brain Barrier ◽  
Blood Brain

scholarly journals Overcoming the blood–brain barrier by Annexin A1-binding peptide to target brain tumours

2020 ◽  
Vol 123 (11) ◽  
pp. 1633-1643 ◽  
Author(s):  
Motohiro Nonaka ◽  
Misa Suzuki-Anekoji ◽  
Jun Nakayama ◽  
Hideaki Mabashi-Asazuma ◽  
Donald L. Jarvis ◽  
...  
Keyword(s):  
Brain Tumour ◽  
Blood Brain Barrier ◽  
Mouse Models ◽  
Nude Mice ◽  
Brain Tumours ◽  
Brain Barrier ◽  
Annexin A1 ◽  
Tumour Model ◽  
Blood Brain ◽  
Tumour Vasculature

Abstract Background Annexin A1 is expressed specifically on the tumour vasculature surface. Intravenously injected IF7 targets tumour vasculature via annexin A1. We tested the hypothesis that IF7 overcomes the blood–brain barrier and that the intravenously injected IF7C(RR)-SN38 eradicates brain tumours in the mouse. Methods (1) A dual-tumour model was generated by inoculating luciferase-expressing melanoma B16 cell line, B16-Luc, into the brain and under the skin of syngeneic C57BL/6 mice. IF7C(RR)-SN38 was injected intravenously daily at 7.0 μmoles/kg and growth of tumours was assessed by chemiluminescence using an IVIS imager. A similar dual-tumour model was generated with the C6-Luc line in immunocompromised SCID mice. (2) IF7C(RR)-SN38 formulated with 10% Solutol HS15 was injected intravenously daily at 2.5 μmoles/kg into two brain tumour mouse models: B16-Luc cells in C57BL/6 mice, and C6-Luc cells in nude mice. Results (1) Daily IF7C(RR)-SN38 injection suppressed tumour growth regardless of cell lines or mouse strains. (2) Daily injection of Solutol-formulated IF7C(RR)-SN38 led into complete disappearance of B16-Luc brain tumour in C57BL/6 mice, whereas this did not occur in C6-Luc in nude mice. Conclusions IF7C(RR)-SN38 crosses the blood–brain barrier and suppresses growth of brain tumours in mouse models. Solutol HS15-formulated IF7C(RR)-SN38 may have promoted an antitumour immune response.

scholarly journals Overcoming the blood–brain barrier in neurodegenerative disorders and brain tumours

2020 ◽  
Vol 14 (6) ◽  
pp. 441-448 ◽  
Author(s):  
Zahra Ebrahimi ◽  
Sam Talaei ◽  
Shahin Aghamiri ◽  
Nasser Hashemi Goradel ◽  
Ali Jafarpour ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Neurodegenerative Disorders ◽  
Brain Tumours ◽  
Brain Barrier ◽  
Blood Brain

scholarly journals Engineered nanoparticles for systemic siRNA delivery to malignant brain tumours

Nanoscale ◽  
2019 ◽  
Vol 11 (42) ◽  
pp. 20045-20057 ◽  
Author(s):  
Johan Karlsson ◽  
Yuan Rui ◽  
Kristen L. Kozielski ◽  
Amanda L. Placone ◽  
Olivia Choi ◽  
...  
Keyword(s):  
Mouse Model ◽  
Gene Silencing ◽  
Blood Brain Barrier ◽  
Brain Tumours ◽  
Sirna Delivery ◽  
Engineered Nanoparticles ◽  
Brain Barrier ◽  
Blood Brain ◽  
Malignant Brain Tumours

Bioreducible nanoparticles were engineered for safe and effective systemic siRNA delivery, including crossing the blood–brain barrier to achieve in vivo gene silencing in an orthotopic glioblastoma mouse model.

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