scholarly journals Fundamentals of Gene and Viral Therapy for Malignant Gliomas

10.5772/21285 ◽  
2011 ◽  
Author(s):  
Farizan Ahmad ◽  
Jafri Malin
Keyword(s):  
Malignant Gliomas ◽  
Viral Therapy

Expanded spectrum of viral therapy in the treatment of nervous system tumors

1992 ◽  
Vol 77 (4) ◽  
pp. 590-594 ◽  
Author(s):  
James M. Markert ◽  
Donald M. Coen ◽  
Amy Malick ◽  
Toshihiro Mineta ◽  
Robert L. Martuza
Keyword(s):  
Cell Culture ◽  
Nervous System ◽  
Malignant Gliomas ◽  
Treated Group ◽  
Early Passage ◽  
Content Type ◽  
Nervous System Tumors ◽  
Viral Therapy ◽  
Subrenal Capsule

✓ Despite aggressive therapy, many nervous system neoplasms, including malignant gliomas, medulloblastomas, malignant meningiomas, and neurofibrosarcomas, maintain high mortality rates. The authors recently utilized a thymidine kinase-negative herpes simplex-1 mutant virus, dlsptk, with reduced neurovirulence, for the effective treatment of malignant human gliomas in cell culture and in nude mouse in vivo models. The range of human nervous system tumors that might be responsive to viral therapy is now expanded. Three medulloblastoma, four malignant or atypical meningioma, and five neurofibrosarcoma cell lines or early-passage tumors were treated with the dlsptk virus in cell culture. A cell death rate of at least 99% was evident in every tumor tested for at least one multiplicity of infection within 14 days after treatment. Control tumor cell cultures remained viable. To test dlsptk therapy in vivo, the authors treated human medulloblastoma subcutaneous xenografts with two doses of dlsptk. Mean growth ratios were significantly inhibited in the treated group when compared to control tumors, and there was a significant number of tumor regressions in the treated animals. Similar results were seen with human malignant meningioma xenografts in a subrenal capsule study. These results encourage the further investigation of viral therapy in the treatment of a broad spectrum of nervous system tumors refractory to conventional treatment methods.

Clinical trials of viral therapy for malignant gliomas

2013 ◽  
Vol 13 (11) ◽  
pp. 1297-1305 ◽  
Author(s):  
David E Piccioni ◽  
Santosh Kesari
Keyword(s):  
Clinical Trials ◽  
Malignant Gliomas ◽  
Viral Therapy

Oncolytic viral therapy for malignant gliomas using myxoma virus deleted for antiapoptotic M11L gene.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 3105-3105
Author(s):  
Peter A. J. Forsyth ◽  
Brienne McKenzie ◽  
Alexandra Pisklakova ◽  
Rajappa Kenchappa ◽  
Grant McFadden
Keyword(s):  
Malignant Gliomas ◽  
Myxoma Virus ◽  
Oncolytic Viral Therapy ◽  
Viral Therapy

scholarly journals ET-46 * ONCOLYTIC VIRAL THERAPY FOR MALIGNANT GLIOMAS USING MYXOMA VIRUS DELETED FOR ANTI-APOPTOTIC M11L GENE

2014 ◽  
Vol 16 (suppl 5) ◽  
pp. v89-v89
Author(s):  
A. Pisklakova ◽  
B. McKenzie ◽  
R. Kenchappa ◽  
G. McFadden ◽  
P. Forsyth
Keyword(s):  
Malignant Gliomas ◽  
Myxoma Virus ◽  
Oncolytic Viral Therapy ◽  
Viral Therapy
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