Anesthetic Considerations of Brain Tumor Surgery

Abstract It is reported that the development of new perioperative motor deficits was associated with decreased overall survival despite similar extent of resection and adjuvant therapy. The maximum safe resection without any neurological deficits is required to improve overall survival in patients with brain tumor. Surgery is performed with various modalities, such as neuro-monitoring, photodynamic diagnosis, neuro-navigation, awake craniotomy, intraoperative MRI, and so on. Above all, awake craniotomy technique is now the standard procedure to achieve the maximum safe resection in patients with brain tumor. It is well known that before any treatment, gliomas generate globally (and not only focally) altered functional connectomics profiles, with various patterns of neural reorganization allowing different levels of cognitive compensation. Therefore, perioperative cortical mapping and elucidation of functional network, neuroplasticity and reorganization are important for brain tumor surgery. On the other hand, recent studies have proposed several gene signatures as biomarkers for different grades of gliomas from various perspectives. Then, we aimed to identify these biomarkers in pre-operative and/or intra-operative periods, using liquid biopsy, immunostaining and various PCR methods including rapid genotyping assay. In this presentation, we would like to demonstrate our surgical strategy based on molecular and functional connectomics profiles.

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Clinical outcome assessments of motor status in patients undergoing brain tumor surgery

Clinical Neurology and Neurosurgery ◽

10.1016/j.clineuro.2020.106420 ◽

2021 ◽

Vol 201 ◽

pp. 106420

Author(s):

Mayla Santana Correia ◽

Iuri Santana Neville ◽

Cesar Cimonari de Almeida ◽

Cintya Yukie Hayashi ◽

Luana Talita Diniz Ferreira ◽

...

Keyword(s):

Brain Tumor ◽

Clinical Outcome ◽

Tumor Surgery ◽

Brain Tumor Surgery ◽

Outcome Assessments ◽

Clinical Outcome Assessments

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Optimization of concentric-tube robot design for deep anterior brain tumor surgery

2016 14th International Conference on Control, Automation, Robotics and Vision (ICARCV) ◽

10.1109/icarcv.2016.7838563 ◽

2016 ◽

Cited By ~ 1

Author(s):

Mohamed Boushaki ◽

Chao Liu ◽

Benoit Herman ◽

Vincent Trevillot ◽

Mohamed Akkari ◽

...

Keyword(s):

Brain Tumor ◽

Robot Design ◽

Tumor Surgery ◽

Brain Tumor Surgery ◽

Concentric Tube Robot

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Perioperative levetiracetam for prevention of seizures in supratentorial brain tumor surgery

Journal of Neuro-Oncology ◽

10.1007/s11060-010-0235-4 ◽

2010 ◽

Vol 101 (1) ◽

pp. 101-106 ◽

Cited By ~ 59

Author(s):

Iris Zachenhofer ◽

Markus Donat ◽

Stefan Oberndorfer ◽

Karl Roessler

Keyword(s):

Brain Tumor ◽

Tumor Surgery ◽

Brain Tumor Surgery

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Association of preoperative hypoalbuminemia with postoperative acute kidney injury in patients undergoing brain tumor surgery: a retrospective study

Journal of Neurosurgery ◽

10.3171/2016.11.jns162237 ◽

2018 ◽

Vol 128 (4) ◽

pp. 1115-1122 ◽

Cited By ~ 6

Author(s):

Kyungmi Kim ◽

Ji-Yeon Bang ◽

Seon-Ok Kim ◽

Saegyeol Kim ◽

Joung Uk Kim ◽

...

Keyword(s):

Acute Kidney Injury ◽

Brain Tumor ◽

Serum Albumin ◽

Serum Albumin Level ◽

Kidney Injury ◽

Albumin Level ◽

Tumor Surgery ◽

Brain Tumor Surgery ◽

Preoperative Serum ◽

Postoperative Aki

OBJECTIVEHypoalbuminemia is known to be independently associated with postoperative acute kidney injury (AKI). However, little is known about the association between the preoperative serum albumin level and postoperative AKI in patients undergoing brain tumor surgery. The authors investigated the incidence of AKI, impact of preoperative serum albumin level on postoperative AKI, and death in patients undergoing brain tumor surgery.METHODSThe authors retrospectively reviewed the electronic medical records and laboratory results of 2363 patients who underwent brain tumor surgery between January 2008 and December 2014. Postoperative AKI was defined according to Kidney Disease: Improving Global Outcomes Definition and Staging (KDIGO). Multivariate logistic regression analysis was used to identify demographic, preoperative laboratory, and intraoperative factors associated with AKI development. Cox proportional hazards models were used to investigate the adjusted odds ratio and hazard ratio for the association between preoperative serum albumin level and outcome variables.RESULTSThe incidence of AKI was 1.8% (n = 43) using KDIGO criteria. The incidence of AKI was higher in patients with a preoperative serum albumin level < 3.8 g/dl (3.5%) than in those with a preoperative serum albumin level ≥ 3.8 g/dl (1.2%, p < 0.001). The overall mortality was also higher in the former than in the latter group (5.0% vs 1.8%, p < 0.001). After inverse probability of treatment-weighting adjustment, a preoperative serum albumin level < 3.8 g/dl was also found to be associated with postoperative AKI (OR 1.981, 95% CI 1.022–3.841; p = 0.043) and death (HR 2.726, 95% CI 1.522–4.880; p = 0.001).CONCLUSIONSThe authors’ results demonstrated that a preoperative serum albumin level of < 3.8 g/dl was independently associated with AKI and mortality in patients undergoing brain tumor surgery.

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