scholarly journals Multifunctional Magnetic Hybrid Nanoparticles as a Nanomedical Platform for Cancer-Targeted Imaging and Therapy

10.5772/20999 ◽  
2012 ◽  
Author(s):  
Husheng Yan ◽  
Miao Guo ◽  
Keliang Liu
Keyword(s):  
Hybrid Nanoparticles ◽  
Targeted Imaging

Targeted imaging of brain gliomas using multifunctional Fe3O4/MnO nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (42) ◽  
pp. 33639-33645 ◽  
Author(s):  
Shuai Li ◽  
Chen Shao ◽  
Wei Gu ◽  
Rui Wang ◽  
Juan Zhang ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Hybrid Nanoparticles ◽  
Targeted Imaging ◽  
Dual Modality ◽  
Brain Gliomas

The CTX-conjugated Fe3O4/MnO hybrid nanoparticles were synthesized and their feasibility for targeted dual-modality T1–T2 MR imaging of brain gliomas was demonstrated.

Radiolabeled Peptide Probes for Liver Cancer Imaging

2020 ◽  
Vol 27 (41) ◽  
pp. 6968-6986
Author(s):  
Rui Cao ◽  
Hongguang Liu ◽  
Zhen Cheng
Keyword(s):  
Liver Cancer ◽  
Cancer Diagnosis ◽  
Cancer Imaging ◽  
Growth Factor Receptor ◽  
Targeted Imaging ◽  
Cancer Death ◽  
Binding Properties ◽  
Radiolabeled Peptides ◽  
Epidermal Growth ◽  
Peptide Probes

Liver cancer/Hepatocellular Carcinoma (HCC) is a leading cause of cancer death and represents an important cause of mortality worldwide. Several biomarkers are overexpressed in liver cancer, such as Glypican 3 (GPC3) and Epidermal Growth Factor Receptor (EGFR). These biomarkers play important roles in the progression of tumors and could serve as imaging and therapeutic targets for this disease. Peptides with adequate stability, receptor binding properties, and biokinetic behavior have been intensively studied for liver cancer imaging. A great variety of them have been radiolabeled with clinically relevant radionuclides for liver cancer diagnosis, and many are promising imaging and therapeutic candidates for clinical translation. Herein, we summarize the advancement of radiolabeled peptides for the targeted imaging of liver cancer.

Lipid-polymer hybrid nanoparticles: Synthesis strategies and biomedical applications

2019 ◽  
Vol 160 ◽  
pp. 130-142 ◽  
Author(s):  
Vivek Dave ◽  
Kajal Tak ◽  
Amit Sohgaura ◽  
Ashish Gupta ◽  
Veera Sadhu ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Nanoparticles Synthesis

scholarly journals Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA

Cells ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 2034 ◽  
Author(s):  
Christian D. Siewert ◽  
Heinrich Haas ◽  
Vera Cornet ◽  
Sara S. Nogueira ◽  
Thomas Nawroth ◽  
...  
Keyword(s):  
Small Angle ◽  
Messenger Rna ◽  
Physicochemical Characterization ◽  
Single Step ◽  
Model Systems ◽  
Molecular Organization ◽  
Hybrid Nanoparticles ◽  
Polymer Mixture ◽  
Internal Organization ◽  
Transfection Efficacy

Hybrid nanoparticles from lipidic and polymeric components were assembled to serve as vehicles for the transfection of messenger RNA (mRNA) using different portions of the cationic lipid DOTAP (1,2-Dioleoyl-3-trimethylammonium-propane) and the cationic biopolymer protamine as model systems. Two different sequential assembly approaches in comparison with a direct single-step protocol were applied, and molecular organization in correlation with biological activity of the resulting nanoparticle systems was investigated. Differences in the structure of the nanoparticles were revealed by thorough physicochemical characterization including small angle neutron scattering (SANS), small angle X-ray scattering (SAXS), and cryogenic transmission electron microscopy (cryo-TEM). All hybrid systems, combining lipid and polymer, displayed significantly increased transfection in comparison to lipid/mRNA and polymer/mRNA particles alone. For the hybrid nanoparticles, characteristic differences regarding the internal organization, release characteristics, and activity were determined depending on the assembly route. The systems with the highest transfection efficacy were characterized by a heterogenous internal organization, accompanied by facilitated release. Such a system could be best obtained by the single step protocol, starting with a lipid and polymer mixture for nanoparticle formation.

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