scholarly journals BRCA2 Mutations and Consequences for DNA Repair

DNA Repair ◽  
10.5772/20941 ◽  
2011 ◽  
Author(s):  
Erika T.
Keyword(s):  
Dna Repair ◽  
Brca2 Mutations

scholarly journals Guardians of the Genome: BRCA2 and Its Partners

Genes ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 1229
Author(s):  
Hang Phuong Le ◽  
Wolf-Dietrich Heyer ◽  
Jie Liu
Keyword(s):  
Dna Repair ◽  
Replication Fork ◽  
Genome Stability ◽  
Strand Break ◽  
Fundamental Properties ◽  
Binding Partners ◽  
Dna Double Strand Break ◽  
Interaction Partners ◽  
Brca2 Mutations ◽  
Mechanistic Understanding

The tumor suppressor BRCA2 functions as a central caretaker of genome stability, and individuals who carry BRCA2 mutations are predisposed to breast, ovarian, and other cancers. Recent research advanced our mechanistic understanding of BRCA2 and its various interaction partners in DNA repair, DNA replication support, and DNA double-strand break repair pathway choice. In this review, we discuss the biochemical and structural properties of BRCA2 and examine how these fundamental properties contribute to DNA repair and replication fork stabilization in living cells. We highlight selected BRCA2 binding partners and discuss their role in BRCA2-mediated homologous recombination and fork protection. Improved mechanistic understanding of how BRCA2 functions in genome stability maintenance can enable experimental evidence-based evaluation of pathogenic BRCA2 mutations and BRCA2 pseudo-revertants to support targeted therapy.

scholarly journals Restoration of CAPAN-1 cells with functional BRCA2 provides insight into the DNA repair activity of individuals who are heterozygous for BRCA2 mutations

2008 ◽  
Vol 186 (2) ◽  
pp. 85-94 ◽  
Author(s):  
Jeffrey T. Holt ◽  
William P. Toole ◽  
Vedang R. Patel ◽  
HeeYoung Hwang ◽  
Erika T. Brown
Keyword(s):  
Dna Repair ◽  
Repair Activity ◽  
Brca2 Mutations ◽  
Insight Into

259: Dna-Repair Genetic Polymorphisms and Prostate Cancer Risk

2005 ◽  
Vol 173 (4S) ◽  
pp. 71-71
Author(s):  
Peter E. Clark ◽  
M. Craig Hall ◽  
Kristin L. Lockett ◽  
Jianfeng Xu ◽  
Sigun L. Zheng ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Prostate Cancer Risk

983: Bladder Cancer Predisposition: A Pathway-Based Approach to DNA Repair and Cell Cycle Control Genes

2006 ◽  
Vol 175 (4S) ◽  
pp. 317-317
Author(s):  
Xifeng Wu ◽  
Jian Gu ◽  
H. Barton Grossman ◽  
Christopher I. Amos ◽  
Carol Etzel ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Bladder Cancer ◽  
Dna Repair ◽  
Cell Cycle Control ◽  
Cancer Predisposition

Drugs Impair Keratinocyte DNA Repair in Culture

2005 ◽  
Vol 36 (7) ◽  
pp. 42
Author(s):  
PATRICE WENDLING
Keyword(s):  
Dna Repair

DNA Repair and Transcription in Human Premature Aging Disorders

1998 ◽  
Vol 3 (1) ◽  
pp. 11-13 ◽  
Author(s):  
Vilhelm A Bohr ◽  
Grigoiy Dianov ◽  
Adayabalam Balajee ◽  
Alfred May ◽  
David K Orren
Keyword(s):  
Dna Repair ◽  
Premature Aging
Sign in / Sign up

Export Citation Format

Share Document