scholarly journals Use of Congenic Mouse Strains for Gene Identification in Type 1 Diabetes

10.5772/20786 ◽  
2011 ◽  
Author(s):  
Ute Christine
Keyword(s):  
Type 1 Diabetes ◽  
Congenic Mouse ◽  
Gene Identification ◽  
Mouse Strains ◽  
Congenic Mouse Strains

scholarly journals Erbb is linked to the alpha-globin locus on mouse chromosome 11.

1985 ◽  
Vol 5 (7) ◽  
pp. 1784-1786 ◽  
Author(s):  
J Silver ◽  
J B Whitney ◽  
C Kozak ◽  
G Hollis ◽  
I Kirsch
Keyword(s):  
Mouse Chromosome ◽  
Human Gene ◽  
Congenic Mouse ◽  
Mouse Strains ◽  
Somatic Cell Hybrids ◽  
Chromosome 11 ◽  
Homologous Sequences ◽  
Alpha Globin ◽  
Mouse Chromosome 11 ◽  
Congenic Mouse Strains

A fragment of the human gene for c-erb-B was used to map homologous sequences in mice. Analysis of somatic cell hybrids and recombinant inbred and congenic mouse strains indicated that this gene, designated Erbb, is closely linked to the gene for alpha-globin on mouse chromosome 11. Several genes controlling hematopoietic differentiation map to mouse chromosome 11.

Mating preferences of F2 segregants of crosses between MHC-congenic mouse strains

1978 ◽  
Vol 6 (1) ◽  
pp. 253-259 ◽  
Author(s):  
K. Yamazaki ◽  
M. Yamaguchi ◽  
P. W. Andrews ◽  
B. Peake ◽  
E. A. Boyse
Keyword(s):  
Congenic Mouse ◽  
Mouse Strains ◽  
Mating Preferences ◽  
Congenic Mouse Strains

Development of intra-natural killer complex (NKC) recombinant and congenic mouse strains for mapping and functional analysis of NK cell regulatory loci

1999 ◽  
Vol 49 (3) ◽  
pp. 238-241 ◽  
Author(s):  
A. A. Scalzo ◽  
Michael G. Brown ◽  
Dortha T. Chu ◽  
Jonathan W. Heusel ◽  
Wayne M. Yokoyama ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Natural Killer ◽  
Nk Cell ◽  
Congenic Mouse ◽  
Mouse Strains ◽  
Regulatory Loci ◽  
Congenic Mouse Strains

scholarly journals Screening for pain phenotypes: Analysis of three congenic mouse strains on a battery of nine nociceptive assays

Pain ◽  
2006 ◽  
Vol 126 (1) ◽  
pp. 24-34 ◽  
Author(s):  
Jeffrey S. Mogil ◽  
Jennifer Ritchie ◽  
Susana G. Sotocinal ◽  
Shad B. Smith ◽  
Sylvie Croteau ◽  
...  
Keyword(s):  
Congenic Mouse ◽  
Mouse Strains ◽  
Congenic Mouse Strains

scholarly journals The alpha-globin pseudogene on mouse chromosome 17 is closely linked to H-2.

1984 ◽  
Vol 159 (3) ◽  
pp. 958-963 ◽  
Author(s):  
P D'Eustachio ◽  
B Fein ◽  
J Michaelson ◽  
B A Taylor
Keyword(s):  
Dna Sequences ◽  
Inbred Strains ◽  
Congenic Mouse ◽  
Chromosome 17 ◽  
Mouse Strains ◽  
Globin Genes ◽  
Somatic Cell Hybrids ◽  
Chromosome 11 ◽  
Alpha Globin ◽  
Congenic Mouse Strains

DNA sequences homologous to adult alpha-globin genes are dispersed in the mouse. Two functional genes are tightly linked on chromosome 11. Pseudogenes have been assigned to chromosomes 15 and 17 by analysis of interspecies somatic cell hybrids. We have now further characterized the second of these pseudogenes, Hba-a4. The gene is highly polymorphic, with three forms occurring in a panel of 15 inbred strains and a fourth occurring in an inbred strain derived from M. m. molossinus. Analysis of Hba-a4 alleles in CXB, BXH, and AKXL recombinant inbred strains placed Hba-a4 6.60 +/- 3.14 cM centromeric to H-2. Analysis of congenic mouse strains confirmed the linkage and the gene order. Hba-a4 is the first mammalian dispersed pseudogene to be localized in a linkage map, and should provide a useful marker for the region of chromosome 17 proximal to H-2.

Differences in susceptibility to develop parameters of diabetic nephropathy in four mouse strains with type 1 diabetes

2014 ◽  
Vol 306 (10) ◽  
pp. F1171-F1178 ◽  
Author(s):  
Stephanie Franzén ◽  
Malou Friederich-Persson ◽  
Angelica Fasching ◽  
Peter Hansell ◽  
Masaomi Nangaku ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 1 Diabetes ◽  
Diabetic Nephropathy ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Mouse Strains ◽  
Histological Damage ◽  
Glomerular Damage

One-third of diabetes mellitus patients develop diabetic nephropathy, and with underlying mechanisms unknown it is imperative that diabetic animal models resemble human disease. The present study investigated the susceptibility to develop diabetic nephropathy in four commonly used and commercially available mouse strains with type 1 diabetes to determine the suitability of each strain. Type 1 diabetes was induced in C57Bl/6, NMRI, BALB/c, and 129Sv mice by alloxan, and conscious glomerular filtration rate, proteinuria, and oxidative stress levels were measured in control and diabetic animals at baseline and after 5 and 10 wk. Histological alterations were analyzed using periodic acid-Schiff staining. Diabetic C57Bl/6 displayed increased glomerular filtration rate, i.e., hyperfiltration, whereas all other parameters remained unchanged. Diabetic NMRI developed the most pronounced hyperfiltration as well as increased oxidative stress and proteinuria but without glomerular damage. Diabetic BALB/c did not develop hyperfiltration but presented with pronounced proteinuria, increased oxidative stress, and glomerular damage. Diabetic 129Sv displayed proteinuria and increased oxidative stress without glomerular hyperfiltration or damage. However, all strains displayed intrastrain correlation between oxidative stress and proteinuria. In conclusion, diabetic C57Bl/6 and NMRI both developed glomerular hyperfiltration but neither presented with histological damage, although NMRI developed low-degree proteinuria. Thus these strains may be suitable when investigating the mechanism causing hyperfiltration. Neither BALB/c nor 129Sv developed hyperfiltration although both developed pronounced proteinuria. However, only BALB/c developed detectable histological damage. Thus BALB/c may be suitable when studying the roles of proteinuria and histological alterations for the progression of diabetic nephropathy.

scholarly journals Genetic Mapping of Vocalization to a Series of Increasing Acute Footshocks Using B6.A Consomic and B6.D2 Congenic Mouse Strains

2008 ◽  
Vol 38 (4) ◽  
pp. 417-423 ◽  
Author(s):  
Douglas B. Matthews ◽  
Elissa J. Chesler ◽  
Melloni N. Cook ◽  
Jody Cockroft ◽  
Vivek M. Philip ◽  
...  
Keyword(s):  
Genetic Mapping ◽  
Congenic Mouse ◽  
Mouse Strains ◽  
Congenic Mouse Strains
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