scholarly journals Structure and Toxicity of the Prefibrillar Aggregation States of Beta Peptides in Alzheimer’s Disease

10.5772/20764 ◽  
2011 ◽  
Author(s):  
Angelo Perico ◽  
Denise Galante ◽  
Cristina DArrigo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Beta Peptides

scholarly journals Intracellular APP Domain Regulates Serine-Palmitoyl-CoA Transferase Expression and Is Affected in Alzheimer's Disease

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Marcus O. W. Grimm ◽  
Sven Grösgen ◽  
Tatjana L. Rothhaar ◽  
Verena K. Burg ◽  
Benjamin Hundsdörfer ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
De Novo ◽  
Physiological Function ◽  
Proteolytic Processing ◽  
Sphingolipid Metabolism ◽  
Amyloid Beta Peptides ◽  
Beta Peptides ◽  
Coa Transferase ◽  
Key Enzyme

Lipids play an important role as risk or protective factors in Alzheimer's disease (AD), a disease biochemically characterized by the accumulation of amyloid beta peptides (Aβ), released by proteolytic processing of the amyloid precursor protein (APP). Changes in sphingolipid metabolism have been associated to the development of AD. The key enzyme in sphingolipidde novosynthesis is serine-palmitoyl-CoA transferase (SPT). In the present study we identified a new physiological function of APP in sphingolipid synthesis. The APP intracellular domain (AICD) was found to decrease the expression of the SPT subunit SPTLC2, the catalytic subunit of the SPT heterodimer, resulting in that decreased SPT activity. AICD function was dependent on Fe65 and SPTLC2 levels are increased in APP knock-in mice missing a functional AICD domain. SPTLC2 levels are also increased in familial and sporadic ADpostmortembrains, suggesting that SPT is involved in AD pathology.

scholarly journals Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease

2009 ◽  
Vol 5 (1) ◽  
pp. 18-29 ◽  
Author(s):  
Alex E. Roher ◽  
Chera L. Esh ◽  
Tyler A. Kokjohn ◽  
Eduardo M. Castaño ◽  
Gregory D. Van Vickle ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Human Plasma ◽  
Amyloid Beta ◽  
Amyloid Beta Peptides ◽  
Beta Peptides

Efficient Processing of Alzheimer's Disease Amyloid-Beta Peptides by Neuroectodermally Converted Mesenchymal Stem Cells

2010 ◽  
Vol 19 (5) ◽  
pp. 629-633 ◽  
Author(s):  
Hans-Jörg Habisch ◽  
Benjamin Schmid ◽  
Christine A.F. von Arnim ◽  
Albert C. Ludolph ◽  
Rolf Brenner ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Amyloid Beta ◽  
Amyloid Beta Peptides ◽  
Beta Peptides ◽  
Efficient Processing

171: The Effect of Oxybutynin Treatment on Plaques, Amyloid-Beta Peptides (ABP), and Behavior in Mouse and Human Cybrid Models of Alzheimer’s Disease

2006 ◽  
Vol 175 (4S) ◽  
pp. 55-55 ◽  
Author(s):  
Seema Sharma ◽  
Adam P. Klausner ◽  
Sophie G. Fletcher ◽  
Sang-Kuk Yang ◽  
Hwancheol Son ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Amyloid Beta Peptides ◽  
Beta Peptides ◽  
And Behavior
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