scholarly journals T Lymphocyte Characteristics and Immune Tolerance During Human Pregnancy

10.5772/20087 ◽  
2011 ◽  
Author(s):  
Gergely Toldi ◽  
Andras Treszl ◽  
Barna Vasarhelyi
Keyword(s):  
T Lymphocyte ◽  
Immune Tolerance ◽  
Human Pregnancy

scholarly journals Interleukin-33-induced immune tolerance is associated with the imbalance of memory and naïve T-lymphocyte subsets

2016 ◽  
Vol 14 (5) ◽  
pp. 4837-4843 ◽  
Author(s):  
Xu Shi ◽  
Ying Tang ◽  
Xiguang Sun ◽  
Yufei Liu ◽  
Ying Sun ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Immune Tolerance ◽  
Lymphocyte Subsets ◽  
T Lymphocyte Subsets ◽  
Interleukin 33

scholarly journals Characterization of dendritic cell (DC)-10 in recurrent miscarriage and recurrent implantation failure

Reproduction ◽  
2019 ◽  
Vol 158 (3) ◽  
pp. 247-255
Author(s):  
Su Liu ◽  
Hongxia Wei ◽  
Yuye Li ◽  
Lianghui Diao ◽  
Ruochun Lian ◽  
...  
Keyword(s):  
Mhc Class Ii ◽  
Immune Tolerance ◽  
Recurrent Miscarriage ◽  
Critical Role ◽  
Costimulatory Molecule ◽  
Normal Pregnancy ◽  
Implantation Failure ◽  
Recurrent Implantation Failure ◽  
Human Pregnancy

During pregnancy, the maternal immune system must tolerate the persistence of semi-allogeneic fetus in the maternal tissue. Inadequate recognition of fetal antigens may lead to pregnancy complications, such as recurrent miscarriage (RM) and recurrent implantation failure (RIF). Dendritic cells (DCs) are key regulators of protective immune responses and the development and maintenance of tolerance. Regarding that DCs are important in the establishment of immune tolerance in human pregnancy, it would be important to study the microenvironment in which DCs reside or are activated may affect their functions toward tolerance rather than active immune response. IL-10 plays a critical role in the maintenance of normal pregnancy, and the increased production of IL-10 is associated with successful pregnancy. In this study, we provide an in-depth comparison of the phenotype and cytokine production by DC-10 and other DC subsets, such as iDC and mDC. CD14+ monocyte-derived DCs were differentiated in the presence of IL-10 (DC-10) in vitro from ten normal fertile controls, six RM women and seven RIF women, and characterized for relevant markers. DC-10 was characterized by relatively low expression of costimulatory molecule CD86, as well as MHC class II molecule HLA-DR, high expression of tolerance molecules HLA-G, ILT2, ILT4 and immunosuppressive cytokine IL-10, but produced little or no proinflammatory cytokines, such as TNF-α, IL-6 and IL-12p70. Our study provides a better understanding of the phenotypical properties of DC-10, which may participate in the complex orchestration that leads to maternal immune tolerance and homeostatic environment in human pregnancy.

Suppression of cytotoxic T-lymphocyte activity during human pregnancy

1993 ◽  
Vol 23 (2) ◽  
pp. 119-130 ◽  
Author(s):  
Naoki Nakamura ◽  
Kohji Miyazaki ◽  
Yoichiro Kitano ◽  
Syunichi Fujisaki ◽  
Hitoshi Okamura
Keyword(s):  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Human Pregnancy ◽  
Lymphocyte Activity

MgAl-layered double hydroxide nanoparticles co-delivering siIDO and Trp2 peptide effectively reduce IDO expression and induce cytotoxic T-lymphocyte responses against melanoma tumor in mice

2017 ◽  
Vol 5 (31) ◽  
pp. 6266-6276 ◽  
Author(s):  
Ling-xiao Zhang ◽  
Dong-qun Liu ◽  
Shao-wei Wang ◽  
Xiao-lin Yu ◽  
Mei Ji ◽  
...  
Keyword(s):  
Layered Double Hydroxide ◽  
T Lymphocyte ◽  
Immune Tolerance ◽  
Cytotoxic T Lymphocyte ◽  
Melanoma Tumor ◽  
Lymphocyte Responses ◽  
Double Hydroxide ◽  
Layered Double Hydroxide Nanoparticles ◽  
Ctl Responses

The co-delivery of Trp2 and siIDO by LDH nanoparticles alleviates immune tolerance and promotes CTL responses in vivo.

Effect of progesterone antagonist mifepristone on plasma CRH in term human pregnancy

1998 ◽  
Vol 5 (1) ◽  
pp. 196A-196A
Author(s):  
J BYRNE ◽  
D WING ◽  
M FRASER ◽  
M FASSETT ◽  
A BOCKING ◽  
...  
Keyword(s):  
Human Pregnancy ◽  
Progesterone Antagonist
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