scholarly journals Mechanisms of Tolerance: Role of the Thymus and Persistence of Antigen in Calcineurin-Induced Tolerance of Renal Allografts in MGH Miniature Swine

10.5772/18909 ◽  
2011 ◽  
Author(s):  
Joseph R. ◽  
Isabel Hanekamp ◽  
Kazuhiko Yam
Keyword(s):  
Miniature Swine ◽  
Renal Allografts ◽  
Induced Tolerance

MECHANISMS OF TACROLIMUS INDUCED TOLERANCE TO FULLY MHC-MISMATCHED RENAL ALLOGRAFTS IN MINIATURE SWINE: DONOR ANTIGEN SPECIFIC REGULATORY MECHANISMS.

2000 ◽  
Vol 69 (Supplement) ◽  
pp. S124-S125 ◽  
Author(s):  
Ryu Utsugi ◽  
Richard S. Lee ◽  
Rolf N. Barth ◽  
Hiroshi Kitamura ◽  
David H. Sachs ◽  
...  
Keyword(s):  
Regulatory Mechanisms ◽  
Miniature Swine ◽  
Renal Allografts ◽  
Induced Tolerance

scholarly journals Role of the Thymus in Transplantation Tolerance in Miniature Swine. I. Requirement of the Thymus for Rapid and Stable Induction of  Tolerance to Class I–mismatched Renal Allografts

1997 ◽  
Vol 186 (4) ◽  
pp. 497-506 ◽  
Author(s):  
Kazuhiko Yamada ◽  
Pierre R. Gianello ◽  
Francesco L. Ierino ◽  
Thomas Lorf ◽  
Akira Shimizu ◽  
...  
Keyword(s):  
T Cell ◽  
Class I ◽  
Striking Difference ◽  
Large Animal ◽  
Miniature Swine ◽  
Renal Allografts ◽  
Large Animal Models ◽  
Induction Of Tolerance

The almost uniform failure in transplant patients of tolerance-inducing regimens that have been found to be effective in rodents, has made it necessary to examine large animal models before testing of new approaches clinically. Miniature swine have been shown to share many relevant immunologic parameters with humans, and because of their reproducible genetics, have proved extremely useful in providing such a large animal model. We have previously shown that indefinite systemic tolerance to renal allografts in miniature swine is induced in 100% of cases across a two-haplotype class I plus minor histocompatibility antigen disparity by a 12-d course of Cyclosporine A (CyA), in contrast to irreversible rejection observed uniformly without CyA treatment. In the present study, we have examined the role of the thymus during the induction of tolerance by performing a complete thymectomy 21 d before renal transplantation. This analysis demonstrated a striking difference between thymectomized and nonthymectomized animals. Thymectomized swine developed acute cellular rejection characterized by a T cell (CD25+) infiltrate, tubulitis, endothelialitis and glomerulitis, and anti–donor CTL reactivity in vitro. Nonthymectomized and sham thymectomized animals had a mild T cell infiltrate with few CD25+ cells and no anti–donor CTL response in vitro. These results indicate that the thymus is required for rapid and stable induction of tolerance.

scholarly journals The Induction of Tolerance of Renal Allografts by Adoptive Transfer in Miniature Swine

2013 ◽  
Vol 13 (5) ◽  
pp. 1193-1202 ◽  
Author(s):  
M. Okumi ◽  
J. R. Scalea ◽  
B. C. Gillon ◽  
M. Tasaki ◽  
V. Villani ◽  
...  
Keyword(s):  
Adoptive Transfer ◽  
Miniature Swine ◽  
Renal Allografts ◽  
Induction Of Tolerance

scholarly journals Cellular adaptations in fat tissue of exercise-trained miniature swine: role of excess energy intake

2000 ◽  
Vol 88 (3) ◽  
pp. 881-887 ◽  
Author(s):  
Gale B. Carey
Keyword(s):  
Adipose Tissue ◽  
Energy Intake ◽  
Excess Energy ◽  
Fat Tissue ◽  
Cellular Mechanisms ◽  
Miniature Swine ◽  
Extracellular Adenosine

This study examined the influence of energy expenditure and energy intake on cellular mechanisms regulating adipose tissue metabolism. 1 Twenty-four swine were assigned to restricted-fed sedentary, restricted-fed exercise-trained, full-fed sedentary, or full-fed exercise-trained groups. After 3 mo of treatment, adipocytes were isolated and adipocyte size, adenosine A1 receptor characteristics, and lipolytic sensitivity were measured. Swine were infused with epinephrine during which adipose tissue extracellular adenosine, plasma fatty acids, and plasma glycerol were measured. Results revealed that adipocytes isolated from restricted-fed exercised swine had a smaller diameter, a lower number of A1 receptors, and a greater sensitivity to lipolytic stimulation, compared with adipocytes from full-fed exercised swine. Extracellular adenosine levels were transiently increased on infusion of epinephrine in adipose tissue of restricted-fed exercised but not full-fed exercised swine. These results suggest a role for adenosine in explaining the discrepancy between in vitro and in vivo lipolysis findings and underscore the notion that excess energy intake dampens the lipolytic sensitivity of adipocytes to β-agonists and adenosine, even if accompanied by exercise training.

The Critical Role of Fas-Fas Ligand Interaction in Donor-Specific Transfusion-Induced Tolerance to H-Y Antigen

2004 ◽  
Vol 78 (6) ◽  
pp. 799-806 ◽  
Author(s):  
Ryosuke Minagawa ◽  
Shinji Okano ◽  
Yukihiro Tomita ◽  
Kenji Kishihara ◽  
Hisakata Yamada ◽  
...  
Keyword(s):  
Fas Ligand ◽  
Critical Role ◽  
Ligand Interaction ◽  
Induced Tolerance

scholarly journals Role of adenosine on morphine-induced tolerance and dependennce in rat.

1999 ◽  
Vol 79 ◽  
pp. 240
Author(s):  
Hirohito Shiomi ◽  
Mika Izumitani ◽  
Naomi Masuda ◽  
Toshiyasu Tsujii ◽  
Mikiko Omoto ◽  
...  
Keyword(s):  
Induced Tolerance

Role of suppressor cells in neonatally induced tolerance to transplantable hepatoma 22a

1980 ◽  
Vol 90 (4) ◽  
pp. 1417-1418
Author(s):  
M. F. Nikonova ◽  
I. N. Maiskii ◽  
T. A. Pokrovskaya ◽  
I. V. Demeshina
Keyword(s):  
Suppressor Cells ◽  
Hepatoma 22A ◽  
Induced Tolerance ◽  
Transplantable Hepatoma

REGULATORY ROLE OF NKT CELLS IS MEDIATED BY LY-49 INHIBITORY RECEPTORS IN CYCLOPHOSPHAMIDE (CP)-INDUCED TOLERANCE

2004 ◽  
Vol 78 ◽  
pp. 536
Author(s):  
T Iwai ◽  
Y Tomita ◽  
I Shimizu ◽  
T Kajiwara ◽  
S Okano ◽  
...  
Keyword(s):  
Nkt Cells ◽  
Regulatory Role ◽  
Inhibitory Receptors ◽  
Induced Tolerance

MECHANISM OF TOLERANCE TO CLASS I-MISMATCHED RENAL ALLOGRAFTS IN MINIATURE SWINE

1998 ◽  
Vol 66 (4) ◽  
pp. 454-460 ◽  
Author(s):  
Francesco L. Ierino ◽  
Kazuhiko Yamada ◽  
Thomas Lorf ◽  
John S. Arn ◽  
David H. Sachs
Keyword(s):  
Class I ◽  
Miniature Swine ◽  
Renal Allografts
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