scholarly journals Solitary Epileptic Seizures in the Clinical Practice

Author(s):  
Branislav Kollar ◽  
Katarina Klobucnikov
Author(s):  
Markus Reuber ◽  
Gregg H. Rawlings ◽  
Steven C. Schachter

This chapter assesses how, in clinical practice, the diagnostic and therapeutic borders between epileptic and Psychogenic Non-Epileptic Seizures (PNES) are ill-defined and sometimes contrast with the schematic views offered by scientific reports. It specifically considers two case reports that illustrate how it is difficult to distinguish the two clinical conditions at the time of the diagnosis and, when the diagnosis is apparently clear, to start the correct treatment. The first patient was referred with seizures characterized by “convulsions” accompanied by loss of awareness. His seizures started when he was caught in an emergency and was at risk of death. The second patient, a 24-year-old girl, was hospitalized because she had experienced “convulsive” seizures. She received contrasting opinions regarding her diagnosis.


Author(s):  
Markus Reuber ◽  
Gregg H. Rawlings ◽  
Steven C. Schachter

This chapter studies the experience of a Clinical Psychologist who has conducted some research with patients with Psychogenic Non-Epileptic Seizures (PNES) but has not worked therapeutically with this patient group. What struck the psychologist was the lack of understanding about the condition, among both patients and clinicians. Anxiety goes hand in hand with uncertainty. As a Psychologist, it can feel overwhelming to identify, make sense of, and address the underlying trauma and difficulties of an illness presenting so physically and so strongly within the body. Hopefully, the continued developments in research and clinical practice will help this patient population receive the help and support that is necessary for their recovery.


2019 ◽  
Vol 80 (11) ◽  
pp. 652-657
Author(s):  
Richard Grünewald

Psychogenic non-epileptic seizures (dissociative seizures) are encountered commonly in emergency medicine and in acute medical wards. Although diagnosis is usually deferred to an expert in epilepsy, an understanding of the phenomenon is helpful in acute management of the patient and dealing with associated urgent safeguarding issues. This article describes a simple model of psychogenic non-epileptic seizures that is useful in clinical practice and helpful to staff, patients and their carers.


2018 ◽  
Vol 89 (10) ◽  
pp. A8.2-A8
Author(s):  
d’Ersu Eleanor ◽  
Al-Mayhani Talal ◽  
Sidhu Meneka

IntroductionPsychogenic non-epileptic seizures (PNES) can present a real diagnostic challenge, with subsequent impact on the course of the disorder and its management. A number of studies have looked into predictive factors for PNES. However, no guidance is available for applying the findings of these studies in clinical practice.AimThe aim is to combine the most recognised discriminative features into an integrated clinical tool, ultimately, to improve the predictive value of the medical assessment of patients with possible PNES in a clinic setting. This can be invaluable in centres with limited access to video telemetry (VT).MethodsThe following criteria were employed and compared with the results of VT as gold standard:Patient comorbiditiesConversation analysisReview of system questionnaireIctal semiology and autonomic activationPostictal prolactin and lactateResults and conclusionThis QIP will assess the reliability and validity of various criteria in recognising PNES clinically. Based on our findings, an integrated tool will then be designed as an adjunct to the standard medical assessment in settings where VT is not readily available.


Author(s):  
Markus Reuber ◽  
Gregg H. Rawlings ◽  
Steven C. Schachter

This chapter presents two cases of patients with Non-Epileptic Seizures (NES), which reflect the difficulties encountered in diagnosing and managing patients with this condition. This represents a major challenge in clinical practice. One of the main obstacles to making a correct diagnosis is getting all of the information out of the patient. In both of the cases, the patients were very reluctant to share any personal details, and it was only after a long time that the Neurologist got a clear picture of the situation. However, the dilemma with NES is not only diagnostic but also therapeutic. Specialized psychotherapy for NES is not readily available and adherence to therapy is often problematic, as was the case with both patients. Ultimately, communication during the clinical interview is a very important skill that must be continually improved.


2016 ◽  
Vol 157 (15) ◽  
pp. 563-568
Author(s):  
Melinda Vanya ◽  
Iván Devosa ◽  
Délia Szok ◽  
György Bártfai

Reproductive-aged women with epilepsy may present a number of specific issues to be managed in daily clinical practice. The impact of epileptic seizures and antiepileptic therapy on pregnancy outcome and the risk of teratogenicity should be minimized, which require careful attention and cooperation between obstetric gynecologyst and neurologist. The aim of the present paper is to review the impact of epilepsy attack on fetus and the pathomechanism and teratogenic effect of antiepileptic drugs. Orv. Hetil., 2016, 157(15), 563–568.


Author(s):  
Markus Reuber ◽  
Gregg H. Rawlings ◽  
Steven C. Schachter

This chapter studies the experience of a Clinical Psychologist who has evaluated patients with Psychogenic Non-Epileptic Seizures (PNES). In clinical practice, the Clinical Psychologist has found it essential to understand with each person what the condition means to him or her, and what the symptoms might represent—not unlike working with any other mental health diagnosis. For example, one resilient and talented young person the Clinical Psychologist worked with had infrequent but highly disruptive episodes. After previously being initially diagnosed with epilepsy, she had been more recently confirmed as having PNES. She readily accepted the diagnosis, and in treatment, the clinical psychologist focused on the disconnection between her own bodily experiences and her ability to understand or explain them. By working to identify how her PNES had previously functioned, in their own way, as an adaptive mechanism for her, the Clinical Psychologist was able to help her build a new life in which the seizures no longer had a role.


Author(s):  
V. Pelliccia ◽  
C. Pizzanelli ◽  
S. Pini ◽  
P. Malacarne ◽  
U. Bonuccelli

2020 ◽  
Vol 48 (5) ◽  
pp. 2295-2305
Author(s):  
Jiawei Zhang ◽  
Dandan Li ◽  
Rui Zhang ◽  
Peng Gao ◽  
Rongxue Peng ◽  
...  

The role of miR-21 in the pathogenesis of various liver diseases, together with the possibility of detecting microRNA in the circulation, makes miR-21 a potential biomarker for noninvasive detection. In this review, we summarize the potential utility of extracellular miR-21 in the clinical management of hepatic disease patients and compared it with the current clinical practice. MiR-21 shows screening and prognostic value for liver cancer. In liver cirrhosis, miR-21 may serve as a biomarker for the differentiating diagnosis and prognosis. MiR-21 is also a potential biomarker for the severity of hepatitis. We elucidate the disease condition under which miR-21 testing can reach the expected performance. Though miR-21 is a key regulator of liver diseases, microRNAs coordinate with each other in the complex regulatory network. As a result, the performance of miR-21 is better when combined with other microRNAs or classical biomarkers under certain clinical circumstances.


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