scholarly journals Corpus Callosotomy in Pediatric Intractable Epilepsy: Microsurgical Technique Implication and Variation

10.5772/18376 ◽  
2011 ◽  
Author(s):  
Eun Kyung ◽  
Dong-Seok Kim
Keyword(s):  
Intractable Epilepsy ◽  
Corpus Callosotomy ◽  
Microsurgical Technique

scholarly journals Postoperative Pneumocephalus on Computed Tomography Might Predict Post-Corpus Callosotomy Chemical Meningitis

2021 ◽  
Vol 11 (5) ◽  
pp. 638
Author(s):  
Ayataka Fujimoto ◽  
Keisuke Hatano ◽  
Toshiki Nozaki ◽  
Keishiro Sato ◽  
Hideo Enoki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Computed Tomography ◽  
Risk Factor ◽  
Intractable Epilepsy ◽  
Epileptic Seizures ◽  
Computed Tomography Scan ◽  
Corpus Callosotomy ◽  
Significant Difference ◽  
Chemical Meningitis ◽  
Tomography Scan

Background: A corpus callosotomy (CC) is a procedure in which the corpus callosum, the largest collection of commissural fibers in the brain, is disconnected to treat epileptic seizures. The occurrence of chemical meningitis has been reported in association with this procedure. We hypothesized that intraventricular pneumocephalus after CC surgery represents a risk factor for postoperative chemical meningitis. The purpose of this study was to analyze the potential risk factors for postoperative chemical meningitis in patients with medically intractable epilepsy who underwent a CC. Methods: Among the patients who underwent an anterior/total CC for medically intractable epilepsy between January 2009 and March 2021, participants were comprised of those who underwent a computed tomography scan on postoperative day 0. We statistically compared the groups with (c-Group) or without chemical meningitis (nc-Group) to determine the risk factors. Results: Of the 80 patients who underwent a CC, 65 patients (25 females and 40 males) met the inclusion criteria. Their age at the time of their CC procedure was 0–57 years. The c-Group (17%) was comprised of seven females and four males (age at the time of their CC procedure, 1–43 years), and the nc-Group (83%) was comprised of 18 females and 36 males (age at the time of their CC procedure, 0–57 years). Mann–Whitney U-tests (p = 0.002) and univariate logistic regression analysis (p = 0.001) showed a significant difference in pneumocephalus between the groups. Conclusion: Postoperative pneumocephalus identified on a computed tomography scan is a risk factor for post-CC chemical meningitis.

Completion Corpus Callosotomy with Stereotactic Radiosurgery for Drug-Resistant, Intractable Epilepsy

2020 ◽  
Vol 143 ◽  
pp. 440-444
Author(s):  
Sean Sachdev ◽  
Timothy L. Sita ◽  
Nathan A. Shlobin ◽  
Mahesh Gopalakrishnan ◽  
Roy Sucholeiki ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Intractable Epilepsy ◽  
Drug Resistant ◽  
Corpus Callosotomy

Seizure Outcomes After Corpus Callosotomy for Drop Attacks

Neurosurgery ◽  
2013 ◽  
Vol 73 (6) ◽  
pp. 993-1000 ◽  
Author(s):  
Regina S. Bower ◽  
Elaine Wirrell ◽  
Macaulay Nwojo ◽  
Nicholas M. Wetjen ◽  
W. Richard Marsh ◽  
...  
Keyword(s):  
Pediatric Population ◽  
Intractable Epilepsy ◽  
Seizure Outcome ◽  
Seizure Onset ◽  
Corpus Callosotomy ◽  
Drop Attacks ◽  
Younger Age ◽  
Age At Surgery ◽  
Adults And Children

Abstract BACKGROUND: Medically intractable epilepsy involving drop attacks can be difficult to manage and negatively affect quality of life. Most studies investigating the effect of corpus callosotomy (CC) on seizures have been limited, focusing on the pediatric population or drop seizures alone, with little attention to other factors influencing seizure outcome. OBJECTIVE: To assess seizure outcomes after CC in adults and children. METHODS: Retrospective analysis was performed on all patients who underwent CC (anterior two thirds, 1- or 2-stage complete) at our institution between 1990 and 2011. Change in frequency after CC was assessed for drop seizures and other seizure types. Multiple factors were evaluated for impact on seizure outcome. RESULTS: Fifty patients met inclusion criteria. The median age was 1.5 years at seizure onset and 17 years at time of surgery. Anterior two-thirds CC was performed in 28 patients, 1-stage complete in 17, and 2-stage complete in 5. All 3 groups experienced a significant decrease in drop seizures (P < .001, P < .001, and P = .020, respectively), with 40% experiencing complete resolution, and 64% dropping at least 1 frequency category. Other seizure types significantly decreased in anterior two-thirds CC and 1-stage complete (P = .0035, P = .001, respectively). Younger age at surgery correlated with better seizure outcomes (P = .043). CONCLUSION: CC for medically refractory generalizing epilepsy is effective for both drop seizures and other seizure types. CC should be considered soon after a patient has been deemed medically refractory because earlier age at surgery results in lower risk and better outcome.

scholarly journals Anterior Corpus Callosotomy in the Treatment of Medically Intractable Epilepsy: Multicenter Study in Japan

Epilepsia ◽  
2000 ◽  
Vol 41 (s9) ◽  
pp. 68-68
Author(s):  
H. Baha ◽  
Y. Mayanagi ◽  
T. Mihara ◽  
T. Sakaki ◽  
T. Tanaka
Keyword(s):  
Multicenter Study ◽  
Intractable Epilepsy ◽  
Corpus Callosotomy

scholarly journals Corpus Callosotomy for Intractable Epilepsy Revisited: The Children’s Hospital of Michigan Series

2017 ◽  
Vol 32 (7) ◽  
pp. 624-629 ◽  
Author(s):  
Aimee F. Luat ◽  
Eishi Asano ◽  
Ajay Kumar ◽  
Harry T. Chugani ◽  
Sandeep Sood
Keyword(s):  
Vagus Nerve ◽  
Intractable Epilepsy ◽  
Endoscopic Approach ◽  
Seizure Outcome ◽  
Nerve Stimulator ◽  
Corpus Callosotomy ◽  
Seizure Reduction ◽  
Palliative Procedure ◽  
Vagus Nerve Stimulator ◽  
Drug Resistant Epilepsy

Corpus callosotomy is a palliative procedure performed to reduce the severity of drug-resistant epilepsy. The authors assessed its efficacy on different seizure types in 20 subjects (age range 5-19 years); 8 with active vagus nerve stimulator. Fifteen had complete callosotomy, 3 had anterior 2/3, and 2 had anterior 2/3 followed later by complete callosotomy. Ten had endoscopic approach. In all, 65% had ≥ 50% reduction of generalized seizures leading to falls (atonic, tonic, myoclonic); 35% became seizure-free (follow-up period: 6 months to 9 years; mean 3 years). Seizure outcome distribution was better for generalized than for partial seizures ( P = .003). Endoscopic approach was as effective as transcranial approach. Seven subjects who failed vagus nerve stimulator therapy responded with ≥50% seizure reduction. Corpus callosotomy is an effective treatment for intractable generalized epilepsy leading to falls with significant seizure reduction or even elimination of seizures, in the majority of children.

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