scholarly journals Effects of Alpha-Synuclein on Cellular Homeostasis

10.5772/17637 ◽  
2011 ◽  
Author(s):  
Kostas Vekrellis ◽  
Georgia Minakaki ◽  
Evangelia Emmanouilidou
Keyword(s):  
Alpha Synuclein ◽  
Cellular Homeostasis

Mitochondrial hyperfusion: a friend or a foe

2020 ◽  
Vol 48 (2) ◽  
pp. 631-644 ◽  
Author(s):  
Rajdeep Das ◽  
Oishee Chakrabarti
Keyword(s):  
Negative Impact ◽  
Cellular Stress ◽  
Cellular Homeostasis ◽  
Mitochondrial Population

The cellular mitochondrial population undergoes repeated cycles of fission and fusion to maintain its integrity, as well as overall cellular homeostasis. While equilibrium usually exists between the fission–fusion dynamics, their rates are influenced by organellar and cellular metabolic and pathogenic conditions. Under conditions of cellular stress, there is a disruption of this fission and fusion balance and mitochondria undergo either increased fusion, forming a hyperfused meshwork or excessive fission to counteract stress and remove damaged mitochondria via mitophagy. While some previous reports suggest that hyperfusion is initiated to ameliorate cellular stress, recent studies show its negative impact on cellular health in disease conditions. The exact mechanism of mitochondrial hyperfusion and its role in maintaining cellular health and homeostasis, however, remain unclear. In this review, we aim to highlight the different aspects of mitochondrial hyperfusion in either promoting or mitigating stress and also its role in immunity and diseases.

Downregulation of Hemeoxygenase-1 and Altered Cellular Homeostasis in Cystic Fibrosis

Pneumologie ◽  
2014 ◽  
Vol 68 (06) ◽  
Author(s):  
SP Chillappagari ◽  
S Venkatesan ◽  
V Garapati ◽  
P Mahavadi ◽  
A Munder ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Cellular Homeostasis

Chaperone mediated degradation of aggregated alpha synuclein

2004 ◽  
Vol 31 (S 1) ◽  
Author(s):  
J Klucken ◽  
Y Shin ◽  
PJ Mclean ◽  
BT Hyman
Keyword(s):  
Alpha Synuclein

Analysis of alpha-synuclein aggregation and associated pathologies in a cellular model of multiple system atrophy

2005 ◽  
Vol 32 (06) ◽  
Author(s):  
G Fillon ◽  
M Neumann ◽  
R Zufferey ◽  
P Aebischer ◽  
HA Kretzschmar ◽  
...  
Keyword(s):  
Multiple System Atrophy ◽  
Alpha Synuclein ◽  
Cellular Model ◽  
Alpha Synuclein Aggregation
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