scholarly journals Multifunctional Nanocomposites Based on Mesoporous Silica: Potential Applications in Biomedicine

10.5772/14595 ◽  
2011 ◽  
Author(s):  
Andreza de ◽  
Karynne Cristina de Souza ◽  
Nelcy D. S. Mohallem ◽  
Ricardo Geraldo de Sousa ◽  
Edesia Martins Barros de Sous
Keyword(s):  
Mesoporous Silica ◽  
Potential Applications ◽  
Multifunctional Nanocomposites

scholarly journals Mesoporous Silica Nanoparticles: Their Projection in Nanomedicine

2012 ◽  
Vol 2012 ◽  
pp. 1-20 ◽  
Author(s):  
María Vallet-Regí
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Surrounding Medium ◽  
Stimuli Responsive ◽  
Guest Molecules ◽  
Different Types ◽  
Potential Applications ◽  
Inorganic Nanomaterials

Mesoporous silica nanoparticles are receiving growing attention by the scientific biomedical community. Among the different types of inorganic nanomaterials, mesoporous silica nanoparticles have emerged as promising multifunctional platforms for nanomedicine. Since their introduction in the drug delivery landscape in 2001, mesoporous materials for drug delivery are receiving growing scientific interest for their potential applications in the biotechnology and nanomedicine fields. The ceramic matrix efficiently protects entrapped guest molecules against enzymatic degradation or denaturation induced by pH and temperature as no swelling or porosity changes take place as a response to variations in the surrounding medium. It is possible to load huge amounts of cargo into the mesopore voids and capping the pore entrances with different nanogates. The application of a stimulus provokes the nanocap removal and triggers the departure of the cargo. This strategy permits the design of stimuli-responsive drug delivery nanodevices.

scholarly journals Versatile Layer-By-Layer Highly Stable Multilayer Films: Study of the Loading and Release of FITC-Labeled Short Peptide in the Drug Delivery Field

Materials ◽  
2019 ◽  
Vol 12 (8) ◽  
pp. 1206 ◽  
Author(s):  
Kun Nie ◽  
Xiang Yu ◽  
Navnita Kumar ◽  
Yihe Zhang
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Multilayer Films ◽  
Layer By Layer ◽  
Guest Molecules ◽  
Potential Applications ◽  
Spatio Temporal ◽  
Release Speed

A viable short FITC-peptide immobilization is the most essential step in the fabrication of multilayer films based on FITC-peptide. These functional multilayer films have potential applications in drug delivery, medical therapy, and so forth. These FITC-peptides films needed to be handled with a lot of care and precision due to their sensitive nature. In this study, a general immobilization method is reported for the purpose of stabilizing various kinds of peptides at the interfacial regions. Utilizing Mesoporous silica nanoparticles can help in the preservation of these FITC-peptides by embedding themselves into these covalently cross-linked multilayers. This basic outlook of the multilayer films is potent enough and could be reused as a positive substrate. The spatio-temporal retention property of peptides can be modulated by varying the number of capping layers. The release speed of guest molecules such as tyrosine within FITC-peptide or/and adamantane (Ad)-in short peptides could also be fine-tuned by the specific arrangements of the multilayers of mesoporous silica nanoparticles (MSNs) and hyaluronic acid- cyclodextrin (HA-CD) multilayer films.

scholarly journals Organic Functionalization of Mesoporous Silica Spheres as a Nanovehicle for DOX pH-Triggered Delivery

NANO ◽  
2019 ◽  
Vol 14 (08) ◽  
pp. 1950094 ◽  
Author(s):  
Shuai Wang ◽  
Fang Xiang Song ◽  
Li Zhang ◽  
Xue Zhang ◽  
Yan Li
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
A549 Cells ◽  
Carboxyl Groups ◽  
Organic Functionalization ◽  
Control Drug ◽  
Potential Applications ◽  
Control Drug Release ◽  
Mesoporous Silica Spheres

Mesoporous silica (MS) spheres of different sizes with pH-responsive characteristics were synthesized based on Stöber’s theory. Organic functionalization with aminopropyl and carboxyl groups resulted in different materials, namely, MS@NH2@COOH. MS@NH2@COOH were observed to have a large number of carboxyl groups and multiamine chains, and were grafted into pore channels and pore outlets through systematic characterization analyses. All modified samples demonstrated the controlling of the delivery rate of DOX from the siliceous matrix. We also compared the drug release behavior of the DOX-loaded materials at high pH (7.4) and low pH (5.5) and studied the cytotoxicity on A549 cells. The experimental results indicated that the drug delivery system can better control drug release and have potential applications in the drug delivery field.

scholarly journals Functionalized Mesoporous Silica Membranes for CO2Separation Applications

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Hyung-Ju Kim ◽  
Hee-Chul Yang ◽  
Dong-Yong Chung ◽  
In-Hwan Yang ◽  
Yun Jung Choi ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Molecular Sieves ◽  
Three Dimensional ◽  
Molecular Transport ◽  
Advanced Materials ◽  
Silica Membranes ◽  
Surface Areas ◽  
Functionalized Mesoporous Silica ◽  
Potential Applications ◽  
And Performance

Mesoporous silica molecular sieves are emerging candidates for a number of potential applications involving adsorption and molecular transport due to their large surface areas, high pore volumes, and tunable pore sizes. Recently, several research groups have investigated the potential of functionalized mesoporous silica molecular sieves as advanced materials in separation devices, such as membranes. In particular, mesoporous silica with a two- or three-dimensional pore structure is one of the most promising types of molecular sieve materials for gas separation membranes. However, several important challenges must first be addressed regarding the successful fabrication of mesoporous silica membranes. First, a novel, high throughput process for the fabrication of continuous and defect-free mesoporous silica membranes is required. Second, functionalization of mesopores on membranes is desirable in order to impart selective properties. Finally, the separation characteristics and performance of functionalized mesoporous silica membranes must be further investigated. Herein, the synthesis, characterization, and applications of mesoporous silica membranes and functionalized mesoporous silica membranes are reviewed with a focus on CO2separation.

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