scholarly journals Pesticides: Genotoxic Risk of Occupational Exposure

10.5772/13631 ◽  
2011 ◽  
Author(s):  
Sandra Gomez-Arroyo ◽  
Carmen Martinez-Valenzuela ◽  
Rafael Villalobos-Pietrini ◽  
Stefan Waliszewski
Keyword(s):  
Occupational Exposure ◽  
Genotoxic Risk

scholarly journals Genotoxicity of Waste Anaesthetic Gases

2002 ◽  
Vol 30 (5) ◽  
pp. 597-602 ◽  
Author(s):  
G. Bozkurt ◽  
D. Memis ◽  
G. Karabogaz ◽  
Z. Pamukcu ◽  
M. Ture ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
High Frequency ◽  
Reference Group ◽  
Low Concentrations ◽  
Anaesthetic Gases ◽  
Carcinogenic Action ◽  
Anaesthesia Practice ◽  
Circulating Lymphocytes ◽  
Genotoxic Risk

Background and aim: The possibility of a potential mutagenic or carcinogenic action of chronic exposure to low concentrations of inhalational anaesthetics has been previously studied, with conflicting results. The purpose of this study was to assess whether occupational exposure to waste anaesthetic gases increases genotoxic risk. We examined peripheral lymphocytes from anaesthetists for both sister chromatid exchange (SCE) and for cells with high-frequency SCEs (HFCs). Method: A group of 16 non-smoking anaesthetists with occupational exposure to anaesthetic gases and a sex- and age-matched group matched 16 non-smoking matched physicians without occupational exposure to anaesthetic gases were studied. The participants were also selected on the basis of similar responses to a questionnaire assessing risk of genotoxicity relating to other aspects of life. Result: SCEs, and HFC percentages obtained from the exposed anaesthetists (6.6±2.4 and 12.2±15.9) were greater but not statistically significantly so than in the reference group (5.2±1.6 and 5.9±10.0). Conclusion: This study does not support the existence of an association between occupational exposure to waste anaesthetic gases and an increase in SCEs in lymphocytes. The nature of our anaesthesia practice suggests exposure was likely to be low. It should be noted that some anaesthetic gases produce lesions that can be efficiently repaired in mitogen-stimulated lymphocytes in vitro but not in circulating lymphocytes.

scholarly journals Health Risk of Occupational Exposure in Welding Processes I. Genotoxic Risk

2003 ◽  
Vol 46 (1) ◽  
pp. 25-29 ◽  
Author(s):  
Lenka Borská ◽  
Zdeněk Fiala ◽  
Jindra Šmejkalová ◽  
Jaroslav Tejral
Keyword(s):  
Occupational Exposure ◽  
Chromosomal Aberrations ◽  
Exposed Group ◽  
International Agency ◽  
Control Group ◽  
Welding Fumes ◽  
Occupationally Exposed ◽  
Polycyclic Aromatic ◽  
Genotoxic Risk ◽  
Welding Processes

The welding processes belong among the important sources of occupational pollutions. The welding fumes are ranked, according to the classification of IARC (International Agency for Research on Cancer), into the group of 2B. In our study we have performed the investigation of twenty men (exposed group) working in the stainless steel welding industrial processes (11 welders and 9 grinders, average age was 31 years, 55 % of smokers, average time period of welding occupational exposure was 8 years). The concentrations of chromium (0.557–16.343 mg/m3) and nickel (0.340–10.129 mg/m3) in occupational atmosphere highly exceeded established values of maximum permitted concentrations (0.1 and 1.0 mg/m3, respectively). The concentrations of manganese did not exceed its permitted values. Total concentrations of 12 polycyclic aromatic hydrocarbons (PAH) in occupational atmosphere varied from 300.9 to 961.2 ng/m3. For purposes of biological monitoring, the levels of chromosomal aberrations were determined in the exposed and control group. Healthy blood donors servedas a control group. People from that group were not occupationally exposed to harmful chemical compounds (20 men, average age was 36 years, 40 % of smokers). Increased level of chromosomal aberrations of exposed group brought the evidence about higher genotoxic risk of investigated welding processes.

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