scholarly journals Combined Exposure to Mixture of Chemicals. An Impossible Challenge?

10.5772/13469 ◽  
2011 ◽  
Author(s):  
Badot Pierre-Marie ◽  
Degiorgi Franois ◽  
Adam Olivier ◽  
Crini Gregorio
Keyword(s):  
Combined Exposure

Complex evaluation of health state of population residing under combined exposure to noise and chemical risk factors caused by activities of major airport hub

2019 ◽  
pp. 12-16 ◽  
Author(s):  
Konstantin P. Luzhetsky ◽  
Ol’ga Yu. Ustinova ◽  
Svetlana S. Kleyn ◽  
Dmitrii N. Koshurnikov ◽  
Svetlana S. Vekovshinina ◽  
...  
Keyword(s):  
Risk Factors ◽  
Nervous System ◽  
Serum Level ◽  
Reference Group ◽  
Risk Index ◽  
Case Based Reasoning ◽  
Health State ◽  
Upper Respiratory Tract ◽  
Combined Exposure ◽  
Complex Evaluation

Complex evaluation covered health state of population residing under combined exposure to physical (noise) and chemical (manganese, formaldehyde, phenol, benzene) risk factors caused by airport activities. Findings are unacceptable chronic risks expressed through risk index for development of nervous system diseases (HI=9.45–51.75), respiratory disorders (HQ=2,62–6,95) and immune system ailments (HQ=1,75–4,23). In children, functional disorders of nervous system (parasympathetic type vegetative dystonia) and respiratory organs (chronic disorders of upper respiratory tract) are diagnosed 1,5–1,8 times higher than those in the reference group; over 5% of children aged 4–7 years demonstrate bilateral conductive deafness. Reliable cause-effect relationships were revealed between functional nervous system disorders (parasympathetic type vegetative dystonia, astheno-neurotic syndrome, vascular cephalgia, sleep disorders) and increased serum level of manganese and benzene (proportion of explained dispersion, R2=0,55–0,87, 26,44≤F≥389,54), between respiratory diseases (chronic rhinitis, chronic pharyngitis) and increased serum level of formaldehyde (R2=0,73–0,91; 350,8≤F≥778,3), with high statistic significance (p < 0,0001). For sanitary epidemiologic examination purposes, case-based reasoning for relationships of children health disorders, management decisions, the authors suggested and justified a list of parameters for negative combined impact of risk factors caused by airport hub.

Protective influence of coded amino acids on the development of liver tissue culture in the presence of cytostatic

2020 ◽  
pp. 48-53
Author(s):  
N. I. Chalisova ◽  
V. K. Kozlov ◽  
A. B. Mulik ◽  
E. P. Zatsepin ◽  
T. A. Kostrova
Keyword(s):  
Amino Acids ◽  
Tissue Culture ◽  
Side Effects ◽  
Liver Tissue ◽  
Organotypic Culture ◽  
Growth Zone ◽  
Inhibitory Effect ◽  
Cytostatic Drugs ◽  
Urgent Problem ◽  
Combined Exposure

An urgent problem is the search for substances that can provide a protective effect in cases of DNA synthesis and repair disorders that arise as a result of side effects of cytostatic drugs used in the treatment of cancer. The aim of this work was to study the effect of 20 encoded amino acids in the presence of Cyclophosphane on the development of organotypic culture of rat liver tissue. The results obtained indicate that Cyclophosphane; which simulates the action of such cytostatic substances; inhibits cell proliferation in the liver tissue. It was also found that the encoded amino acids: asparagine; arginine; and glutamic acid; eliminate the inhibitory effect of Cyclophosphane in liver tissue culture. The growth zone of explants after combined exposure to Cyclophosphane (whose isolated action suppressed the growth zone) and these amino acids increased significantly and reached control values. Thus; the experimental data create the basis for the development of methods for the therapeutic use of the three studied amino acids for the removal of side effects in the treatment with cytostatic drugs.

The effect of combined exposure of zinc and nickel on the development of zebrafish

2021 ◽  
Author(s):  
Yongmeng Yang ◽  
Yue Yu ◽  
Rong Zhou ◽  
Yan Yang ◽  
Yuanqing Bu
Keyword(s):  
Combined Exposure

Effect of separate and combined exposure of selenium and diazinon on rat sperm motility by computer assisted semen analysis

2016 ◽  
Vol 38 ◽  
pp. 144-149 ◽  
Author(s):  
Robert Toman ◽  
Svatoslav Hluchy ◽  
Michal Cabaj ◽  
Peter Massanyi ◽  
Shubhadeep Roychoudhury ◽  
...  
Keyword(s):  
Sperm Motility ◽  
Semen Analysis ◽  
Computer Assisted ◽  
Combined Exposure
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