A Mathematical Model to Predict Short-Term Recurrence and Metastasis of Primary Hepatocellular Carcinoma Larger than 10cm in Diameter

2012 ◽  
Author(s):  
Xinhui Huang ◽  
Wei Wei ◽  
Na Ya ◽  
Jinhua Zeng ◽  
Yongyi Zeng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mathematical Model ◽  
Primary Hepatocellular Carcinoma ◽  
Short Term

scholarly journals Short-term Efficacy and Safety of CalliSpheres Drug-loaded Microsphere Embolization in Primary Hepatocellular Carcinoma

2019 ◽  
Author(s):  
Jinpeng Li ◽  
Nan Wang ◽  
Congcong Shi ◽  
Qingran Liu ◽  
Wenbo Shao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Postoperative Complications ◽  
Liver Function ◽  
Objective Response ◽  
Multivariate Logistic Regression Analysis ◽  
Primary Hepatocellular Carcinoma ◽  
Short Term ◽  
Average Hospital ◽  
Average Interval ◽  
Term Efficacy

Abstract Background To evaluate the short-term clinical efficacy, side effects, and risk factors affecting the clinical effectiveness of CalliSpheres drug-loaded bead-transcatheter arterial chemoembolization (DEB-TACE) in the treatment of primary hepatocellular carcinoma (HCC).Methods A total of 172 consecutive patients with HCC undergoing DEB-TACE (loaded with doxorubicin) from August 2016 to July 2018 were prospectively enrolled. Short-term local tumor response was evaluated by the modified RECIST criteria. Postoperative complications and liver function disorders were analyzed based on examinations and clinical symptoms.Results The median follow-up period was 310 days. Based on the mRECIST criteria, objective response rates (CR+PR) were 78.7%, 71.6% and 63.2%, and disease control rates (CR+PR+SD) were 95.3%, 92.1% and 85.9% at 2, 4 and 6 months post-treatment, respectively. Multivariate logistic regression analysis showed that nodule number >3, high BCLC stage, vascular leak, and previous cTACE treatment were associated with poor ORR (P<0.05). Post-operation, liver function showed transient changes. Postoperative complications were tolerated and relieved by symptomatic treatment. The average interval of TACE before D-TACE was 43 days, compared with 70 days for average interval of DEB-TACE. The average hospital stay was 1.87 days.Conclusions DEB-TACE has improved short-term efficacy and lower incidence of complications in primary HCC and prolongs the interval of TACE. It significantly increases the ORR, especially in patients with no extra-hepatic metastasis pre-treatment. DEB usage actually improves treatment efficacy and provides more benefits to patients.

EXPERIMENTAL STUDIES OF CAR PROPERTIES ON A PHYSICAL MODEL

2019 ◽  
pp. 10-16
Author(s):  
Oleksii Timkov ◽  
Dmytro Yashchenko ◽  
Volodymyr Bosenko
Keyword(s):  
Mathematical Model ◽  
Remote Control ◽  
Physical Model ◽  
Model Experiment ◽  
Experimental Studies ◽  
Electrical Energy ◽  
Short Term ◽  
Motor Current ◽  
Memory Card ◽  
The Mathematical Model

The article deals with the development of a physical model of a car equipped with measuring, recording and remote control equipment for experimental study of car properties. A detailed description of the design of the physical model and of the electronic modules used is given, links to application libraries and the code of the first part of the program for remote control of the model are given. Atmega microcontroller on the Arduino Uno platform was used to manage the model and register the parameters. When moving the car on the memory card saved such parameters as speed, voltage on the motor, current on the motor, the angle of the steered wheel, acceleration along three coordinate axes are recorded. Use of more powerful microcontrollers will allow to expand the list of the registered parameters of movement of the car. It is possible to measure the forces acting on the elements of the car and other parameters. In the future, it is planned to develop a mathematical model of motion of the car and check its adequacy in conducting experimental studies on maneuverability on the physical model. In addition, it is possible to conduct studies of stability and consumption of electrical energy. The physical model allows to quickly change geometric dimensions and mass parameters. In the study of highway trains, this approach will allow to investigate the various layout schemes of highway trains in the short term. It is possible to make two-axle road trains and saddle towed trains, three-way hitched trains of different layout. The results obtained will allow us to improve not only the mathematical model, but also the experimental physical model, and move on to further study the properties of hybrid road trains with an active trailer link. This approach allows to reduce material and time costs when researching the properties of cars and road trains. Keywords: car, physical model, experiment, road trains, sensor, remote control, maneuverability, stability.

Diagnostic Value of Serum Ferritin in Primary Hepatocellular Carcinoma

Digestion ◽  
1984 ◽  
Vol 30 (4) ◽  
pp. 236-241 ◽  
Author(s):  
E. Giannoulis ◽  
C. Arvanitakis ◽  
A. Nikopoulos ◽  
I. Doutsos ◽  
A. Tourkantonis
Keyword(s):  
Hepatocellular Carcinoma ◽  
Serum Ferritin ◽  
Diagnostic Value ◽  
Primary Hepatocellular Carcinoma

scholarly journals Effect of timing of surgical resection of primary hepatocellular carcinoma on survival outcomes in elderly patients and prediction of clinical models

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yongfei He ◽  
Tianyi Liang ◽  
Shutian Mo ◽  
Zijun Chen ◽  
Shuqi Zhao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Overall Survival ◽  
Liver Cancer ◽  
Elderly Patients ◽  
Surgical Resection ◽  
Influencing Factors ◽  
The Elderly ◽  
Primary Hepatocellular Carcinoma ◽  
Surgical Timing ◽  
Duration Of Surgery

Abstract Background The effect of time delay from diagnosis to surgery on the prognosis of elderly patients with liver cancer is not well known. We investigated the effect of surgical timing on the prognosis of elderly hepatocellular carcinoma patients undergoing surgical resection and constructed a Nomogram model to predict the overall survival of patients. Methods A retrospective analysis was performed on elderly patients with primary liver cancer after hepatectomy from 2012 to 2018. The effect of surgical timing on the prognosis of elderly patients with liver cancer was analyzed using the cut-off times of 18 days, 30 days, and 60 days. Cox was used to analyze the independent influencing factors of overall survival in patients, and a prognostic model was constructed. Results A total of 232 elderly hepatocellular carcinoma patients who underwent hepatectomy were enrolled in this study. The cut-off times of 18, 30, and 60 days were used. The duration of surgery had no significant effect on overall survival. Body Mass Index, Child-Pugh classification, Tumor size Max, and Length of stay were independent influencing factors for overall survival in the elderly Liver cancer patients after surgery. These factors combined with Liver cirrhosis and Venous tumor emboli were incorporated into a Nomogram. The nomogram was validated using the clinical data of the study patients, and exhibited better prediction for 1-year, 3-year, and 5-year overall survival. Conclusions We demonstrated that the operative time has no significant effect on delayed operation in the elderly patients with hepatocellular carcinoma, and a moderate delay may benefit some patients. The constructed Nomogram model is a good predictor of overall survival in elderly patients with hepatectomy.

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