Is Cervical Cancer a Risk Factor for Colorectal Neoplasia? Prevalence of Colorectal Adenoma in Korean Patients with Cervical Cancer

2011 ◽  
Vol 58 (109) ◽  
pp. 1177-1181 ◽  
Author(s):  
Yun Jung Kim ◽  
Eun Soo Kim ◽  
Jeong Eun Lee ◽  
Woo Young Park ◽  
Jee Suk Kwon ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Risk Factor ◽  
Colorectal Adenoma ◽  
Colorectal Neoplasia ◽  
Korean Patients

scholarly journals From the Infection to the Immunotherapy in Cervical Cancer: Can We Stop the Natural Course of the Disease?

Vaccines ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 597
Author(s):  
Daniela Luvero ◽  
Salvatore Lopez ◽  
Giorgio Bogani ◽  
Francesco Raspagliesi ◽  
Roberto Angioli
Keyword(s):  
Cervical Cancer ◽  
Radiation Therapy ◽  
Risk Factor ◽  
Hpv Vaccine ◽  
Global Market ◽  
Cancer Death ◽  
Prevention Measures ◽  
Primary And Secondary Prevention ◽  
The World ◽  
Prevention And Treatment

Cervical cancer (CC) is the second leading cause of cancer death in women aged 20–39 years. Persistent infection with oncogenic types of human papillomavirus (HPV) represents the most important risk factor for the development of cervical cancer. Three HPVs vaccines are currently on the global market: bivalent, quadrivalent, and nonavalent. The nonavalent vaccine provides protection against almost 90% of HPV-related CC. Despite availability of primary and secondary prevention measures, CC persists as one of the most common cancers among women around the world. Although CC is a largely preventable disease, management of persistent or recurrent CC no longer amenable to control with surgery or radiation therapy has not improved significantly with the progress of modern chemotherapy and disseminated carcinoma of the cervix remains a discouraging clinical entity with a 1-year survival rate between 10% and 15%. Over the last few years, there has been increasing interest in immunotherapy as a strategy to fight tumors. This article focuses on recent discoveries about the HPV vaccine and immunotherapies in the prevention and treatment of CC, highlighting the future view.

CYP1A1 gene polymorphism as a risk factor for cervical intraepithelial neoplasia and invasive cervical cancer

2006 ◽  
Vol 101 (3) ◽  
pp. 503-506 ◽  
Author(s):  
Cagatay Taskiran ◽  
Dilek Aktas ◽  
Nilufer Yigit-Celik ◽  
Mehmet Alikasifoglu ◽  
Kunter Yuce ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Risk Factor ◽  
Gene Polymorphism ◽  
Cervical Intraepithelial Neoplasia ◽  
Invasive Cervical Cancer ◽  
Intraepithelial Neoplasia ◽  
Cyp1a1 Gene

Is Thyroid Hormone a Risk Factor of Coronary Atherosclerosis in Korean Patients?

2005 ◽  
Vol 35 (1) ◽  
pp. 43
Author(s):  
Kyung Ho Yun ◽  
Myung Ho Jeong ◽  
Dong Goo Kang ◽  
Kye Hun Kim ◽  
Sang Yup Lim ◽  
...  
Keyword(s):  
Risk Factor ◽  
Thyroid Hormone ◽  
Coronary Atherosclerosis ◽  
Korean Patients

scholarly journals Circulating inflammation markers and colorectal adenoma risk

2019 ◽  
Vol 40 (6) ◽  
pp. 765-770 ◽  
Author(s):  
Wen-Yi Huang ◽  
Sonja I Berndt ◽  
Meredith S Shiels ◽  
Hormuzd A Katki ◽  
Anil K Chaturvedi ◽  
...  
Keyword(s):  
Colorectal Adenoma ◽  
Statistical Tests ◽  
Colorectal Neoplasia ◽  
Serum Levels ◽  
Colorectal Carcinogenesis ◽  
Inflammation Markers ◽  
Ovarian Cancer Screening ◽  
Cysteine Motif ◽  
Chemokine Ligand ◽  
Incident Cases

Abstract Inflammation is a driver of colorectal neoplasia; however, what particular inflammatory processes play a role in early carcinogenesis are unclear. We compared serum levels of 78 inflammation markers between 171 pathologically confirmed colorectal adenoma cases (including 48 incident cases) and 344 controls within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. We used weighted multivariable logistic regression to compute odds ratio (OR) and 95% confidence interval (CI). We found 14 markers associated with risk of adenoma overall; three of these were also associated with incident adenoma: CC-chemokine cysteine motif chemokine ligand 20 (CCL20) [overall adenoma fourth versus first quartile: OR 4.8, 95% CI 2.0–12, Ptrend 0.0007; incident adenoma third versus first tertile: OR 4.6, 95% CI 1.0–22, Ptrend 0.03], growth-related gene oncogene products (GRO) [OR 3.8, 95% CI 1.6–9.3, Ptrend 0.006 and OR 3.6, 95% CI 1.1–12, Ptrend 0.04, respectively] and insulin [OR 2.9, 95% CI 0.8–10, Ptrend 0.05 and OR 7.8, 95% CI 1.3–46, Ptrend 0.03, respectively]. All statistical tests were two-sided. These results provide important new evidence implicating CCL20- and GRO-related pathways in early colorectal carcinogenesis and further support a role for insulin.

scholarly journals Cervical Cancer Screening Barriers and Risk Factor Knowledge Among Uninsured Women

2017 ◽  
Vol 42 (4) ◽  
pp. 770-778 ◽  
Author(s):  
Marvellous Akinlotan ◽  
Jane N. Bolin ◽  
Janet Helduser ◽  
Chinedum Ojinnaka ◽  
Anna Lichorad ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Risk Factor ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Screening Barriers

scholarly journals Perineural invasion as a prognostic risk factor in patients with early cervical cancer

2018 ◽  
Author(s):  
Mei Tang ◽  
Qiuli Liu ◽  
Xueqing Yang ◽  
Ling Chen ◽  
Jinjin Yu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Risk Factor ◽  
Perineural Invasion ◽  
Early Cervical Cancer

scholarly journals Amate: A Mobile Application To Improve Access To Early Breast And Cervical Cancer Detection

2018 ◽  
Vol 4 (Supplement 3) ◽  
pp. 26s-26s
Author(s):  
Carlos Munoz-Zuluaga ◽  
Armando Sardi ◽  
Mavalynne Orozco-Urdaneta ◽  
Luis Gabriel Parra-Lara ◽  
Andres Perez ◽  
...  
Keyword(s):  
Health Care ◽  
Cervical Cancer ◽  
Risk Factor ◽  
Early Detection ◽  
Cancer Detection ◽  
Cancer Care ◽  
Early Cancer ◽  
Early Cancer Detection ◽  
Screening Tests ◽  
Breast And Cervical Cancer

Purpose For Colombian women, breast and cervical cancer are the leading causes of mortality, despite being potentially curable through early detection and timely treatment. Tedious administrative processes and a lack of cancer screening education and awareness hinders early detection. Mobile applications (mApps) have permeated all levels of society and are potential tools by which to deliver personalized information and identify high-risk patients in need of screening tests thereby improving early cancer detection. The aim of this work is to create a free mApp that educates and guides patients to the national screening programs for breast and cervical cancer. Methods An mApp Amate was advertised to women (age ≥ 14 years) in the waiting rooms of a health care facility of a community hospital during a period of 9 months. Amate used educational, evaluative, and risk factor questions to measure the population’s knowledge of breast and cervical cancer. Each question was followed by an explanation. Correct answers yielded points that were redeemable for cellular data. Risk assessment questions identified women who required screening who were subsequently contacted by a health care provider and enrolled in the national cancer care program. Results A total of 4,553 women were contacted from August 2017 to May 2018. Of this group, 830 downloaded Amate and answered all of the questions. On the basis of the risk factor questions, 16% of patients (n = 131) were identified as being at risk for breast and/or cervical cancer and needed to be enrolled in the national screening program. Thus far, 24% of patients (n = 32) have successfully completed their recommended screening tests—mammogram, Papanicolau smear, or both. We also identified specific barriers to enrolling patients in these programs, including an unwillingness to be enrolled, limited available appointments at health care centers, and denied access as a result of health care coverage. Conclusion Amate is a low-cost, accessible tool that identifies women who are at risk for breast and cervical cancer and detects access barriers to early cancer detection. Administrative obstacles still exist and must be addressed to improve early cancer detection and screening. Amate has the potential to reach people from rural areas of Colombia and other underserved countries. AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/site/ifc . Armando Sardi Stock or Other Ownership: Celgene, Johnson & Johnson Mavalynne Orozco-Urdaneta Employment: Partners For Cancer Care And Prevention Foundation, Stamina-in-Action Stock or Other Ownership: Celgene, Johnson & Johnson Luis Gabriel Parra-Lara Research Funding: Merk & Co

scholarly journals Women's knowledge about risk factors, prevention and diagnostics of cervical precancerous changes at colposcopy clinic in Latvia

2018 ◽  
Vol 7 (8) ◽  
pp. 3091
Author(s):  
Anita Ungure ◽  
Jana Žodžika ◽  
Nellija Lietuviete ◽  
Dace Rezeberga ◽  
Ilva Šenfelde
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Risk Factor ◽  
Diagnostic Methods ◽  
University Hospital ◽  
Effective Prevention ◽  
Common Information ◽  
Women's Knowledge ◽  
Women’S Knowledge ◽  
Colposcopy Clinic

Background: The incidence of cervical cancer in Latvia is one of the highest among European countries. An organized cervical cancer screening program in Latvia was introduced in 2009. Women’s knowledge and attitude regarding cervical cancer is the key component for successful prevention of this disease. The aim of this study was to evaluate women’s knowledge about the risk factors, prevention and diagnostic methods of precancerous and invasive disease of the uterine cervix in the main colposcopy clinic in Latvia and to compare women's knowledge before and after their first colposcopy visit.Methods: This was a cross sectional study where 100 women were included while attending their first colposcopy visit at Colposcopy Clinic of Riga East Clinical University Hospital. Study was performed in the period September 2017 to November 2017. Exclusion criteria were colposcopy follow-up examination and pregnancy. The most common reason for a planned colposcopy was suspected precancerous changes during cytology testing.Results: The most common information resources regarding reproductive health were gynaecologist (79%) and mass media (51%). Women knowledge about the risk factors of cervical precancerous changes were as follows: 30% marked smoking and 26% - early onset of the first sexual intercourse. 31% of women knew that vaccination against HPV is an effective prevention. 53% of women considered cervical cytology and 52% - colposcopy as a diagnostic method for precancerous changes. Higher number of women evaluated their general knowledge as sufficient after the visit (10% vs. 30%, p<0.05), but only smoking as a risk factor was recognized significantly more often (30% vs. 42%, p<0.05).Conclusions: Although current study presented specific population of women attending Colposcopy clinic because of suspected precancerous disease, less than a half of women knew risk factors, prevention and diagnostics of these changes. Overall women were satisfied with information they received during their first colposcopy visit, but afterward only knowledge about smoking as a possible risk factor improved significantly. It is important to improve women's knowledge about the meaning of prevention methods in order to increase the awareness of cervical cancer in Latvia.

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