Sequence Variation in the Melanocortin-1 Receptor Gene (Mc1r) Does Not Explain Variation in the Degree of Melanism in a Widespread Amphibian

2010 ◽  
Vol 47 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Gábor Herczeg ◽  
Chikako Matsuba ◽  
Juha Merilä
Keyword(s):  
Sequence Variation ◽  
Receptor Gene ◽  
Melanocortin 1 Receptor

scholarly journals Color differences among feral pigeons (Columba livia) are not attributable to sequence variation in the coding region of the melanocortin-1 receptor gene (MC1R)

2013 ◽  
Vol 6 (1) ◽  
pp. 310 ◽  
Author(s):  
Romain Derelle ◽  
Fyodor A Kondrashov ◽  
Vladimir Y Arkhipov ◽  
Hélène Corbel ◽  
Adrien Frantz ◽  
...  
Keyword(s):  
Sequence Variation ◽  
Receptor Gene ◽  
Columba Livia ◽  
Coding Region ◽  
Melanocortin 1 Receptor ◽  
Feral Pigeons ◽  
Color Differences

scholarly journals Sequence variation in the coding region of the melanocortin-1 receptor gene ( MC1R ) is not associated with plumage variation in the blue-crowned manakin ( Lepidothrix coronata )

2006 ◽  
Vol 273 (1594) ◽  
pp. 1613-1618 ◽  
Author(s):  
Z.A Cheviron ◽  
Shannon J Hackett ◽  
Robb T Brumfield
Keyword(s):  
Sequence Variation ◽  
Receptor Gene ◽  
Acid Sites ◽  
Coding Region ◽  
Genetic Changes ◽  
Melanocortin 1 Receptor ◽  
Plumage Polymorphism ◽  
Male Plumage ◽  
Southern Central ◽  
Natural And Sexual Selection

Avian plumage traits are the targets of both natural and sexual selection. Consequently, genetic changes resulting in plumage variation among closely related taxa might represent important evolutionary events. The molecular basis of such differences, however, is unknown in most cases. Sequence variation in the melanocortin-1 receptor gene ( MC1R ) is associated with melanistic phenotypes in many vertebrate taxa, including several avian species. The blue-crowned manakin ( Lepidothrix coronata ), a widespread, sexually dichromatic passerine, exhibits striking geographic variation in male plumage colour across its range in southern Central America and western Amazonia. Northern males are black with brilliant blue crowns whereas southern males are green with lighter blue crowns. We sequenced 810 bp of the MC1R coding region in 23 individuals spanning the range of male plumage variation. The only variable sites we detected among L. coronata sequences were four synonymous substitutions, none of which were strictly associated with either plumage type. Similarly, comparative analyses showed that L. coronata sequences were monomorphic at the three amino acid sites hypothesized to be functionally important in other birds. These results demonstrate that genes other than MC1R underlie melanic plumage polymorphism in blue-crowned manakins.

scholarly journals The “Extended Brown” Plumage Color Mutant of Blue-Breasted Quail (Coturnix chinensis) is Associated with a Mutation in the Melanocortin 1-Receptor Gene (MC1R)

2018 ◽  
Vol 55 (4) ◽  
pp. 233-238 ◽  
Author(s):  
Miho Kageyama ◽  
Atsushi Takenouchi ◽  
Keiji Kinoshita ◽  
Yoshiaki Nakamura ◽  
Masaoki Tsudzuki
Keyword(s):  
Receptor Gene ◽  
Plumage Color ◽  
Melanocortin 1 Receptor ◽  
Color Mutant

Characterisation of the melanocortin-1 receptor gene in alpaca and identification of possible markers associated with phenotypic variations in colour

2009 ◽  
Vol 49 (8) ◽  
pp. 675 ◽  
Author(s):  
N. L. Feeley ◽  
K. A. Munyard
Keyword(s):  
Mus Musculus ◽  
Bos Taurus ◽  
Receptor Gene ◽  
Nucleotide Polymorphisms ◽  
Wild Type ◽  
Single Nucleotide ◽  
Melanocortin 1 Receptor ◽  
Mc1r Gene ◽  
Pcr Products ◽  
Phenotypic Variations

The aim of this study was to determine if any correlation exists between melanocortin-1 receptor (MC1R) polymorphisms and skin and fibre colour in alpacas. Primers capable of amplifying the entire alpaca MC1R gene were designed from a comparative alignment of Bos taurus and Mus musculus MC1R gene sequences. The complete MC1R gene of 41 alpacas exhibiting a range of fibre colours, and which were sourced from farms across Australia, was sequenced from PCR products. Twenty-one single nucleotide polymorphisms were identified within MC1R. Two of these polymorphisms (A82G and C901T) have the potential to reduce eumelanin production by disrupting the activity of MC1R. No agreement was observed between fibre colour alone and MC1R genotype in the 41 animals in this study. However, when the animals were assigned to groups based on the presence or absence of eumelanin in their fibre and skin, only animals that had at least one allele with the A82/C901 combination expressed eumelanin. We propose that A82/C901 is the wild-type dominant ‘E’ MC1R allele, while alpacas with either G82/T901 or G82/Y901 are homozygous for the recessive ‘e’ MC1R allele and are therefore unable to produce eumelanin.

Nucleotide diversity of the melanocortin 1 receptor gene (MC1R) in the gayal (Bos frontalis)

2012 ◽  
Vol 39 (7) ◽  
pp. 7293-7301 ◽  
Author(s):  
Dongmei Xi ◽  
Qing Liu ◽  
Yinqiang Huo ◽  
Yongke Sun ◽  
Jing Leng ◽  
...  
Keyword(s):  
Nucleotide Diversity ◽  
Receptor Gene ◽  
Melanocortin 1 Receptor

scholarly journals Assessing losses of genetic variability in the endangered Mallorquí horse

2010 ◽  
Vol 55 (No. 10) ◽  
pp. 456-462 ◽  
Author(s):  
I. Álvarez ◽  
L.J. Royo ◽  
L. Pérez-Pardal ◽  
I. Fernández ◽  
L. Payeras ◽  
...  
Keyword(s):  
Genetic Variability ◽  
Gene Diversity ◽  
Receptor Gene ◽  
Reference Population ◽  
Coat Colour ◽  
Conservation Strategies ◽  
Effective Number ◽  
Total Contribution ◽  
Melanocortin 1 Receptor ◽  
Future Viability

Information contained in the studbook of the endangered Mallorqu&iacute; horse was analysed to assess the genetic variability of the breed. Also, the effect of selection for coat colour variation was assessed using a set of 15 microsatellites genotyped on 68 Mallorqu&iacute; reproductive individuals previously diagnosed for the presence of the chestnut allele on the melanocortin-1 receptor gene. Mean inbreeding for the whole pedigree (310 individuals) was 2.5% while that for the individuals born during the last three years of recording (reference population) was 4.7%. Only 70% of all the founders have genetic representation in the reference population. A comparison of the parameters such as effective number of founders, effective number of ancestors and founder genome equivalents documented that the losses of founder genes occurred very soon after the implementation of conservation strategies. The parameter F<sub>IS</sub> computed from genealogical information was positive (0.029) for the whole population and negative (&ndash;0.024) for the reference population, thus illustrating the effort of the Mallorqu&iacute; horse breeders to avoid matings between relatives in later generations. A total of 14 individuals were heterozygotes for the chestnut allele (allele frequency of 10.6%). The rejection for reproduction of the chestnut heterozygote individuals would not affect the overall gene diversity of the population. However, the total allelic richness would decrease both at the within-subpopulation (1.2%) and total contribution level (0.4%). The chestnut heterozygote individuals are a within-breed reservoir of rare alleles that should be preserved to avoid risks for the future viability of the breed.

Contribution of melanocortin-1 receptor gene variants to sporadic cutaneous melanoma risk in a population in central Italy: a case???control study

2006 ◽  
Vol 16 (2) ◽  
pp. 175-182 ◽  
Author(s):  
Maria Concetta Fargnoli ◽  
Emma Altobelli ◽  
Gisela Keller ◽  
Sergio Chimenti ◽  
Heinz H??fler ◽  
...  
Keyword(s):  
Cutaneous Melanoma ◽  
Case Control Study ◽  
Receptor Gene ◽  
Central Italy ◽  
Case Control ◽  
Gene Variants ◽  
Melanoma Risk ◽  
Melanocortin 1 Receptor ◽  
Control Study
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