scholarly journals Linkage Disequilibrium Estimation of Chinese Beef Simmental Cattle Using High-density SNP Panels

2013 ◽  
Vol 26 (6) ◽  
pp. 772-779 ◽  
Author(s):  
M. Zhu ◽  
B. Zhu ◽  
Y. H. Wang ◽  
Y. Wu ◽  
L. Xu ◽  
...  
Keyword(s):  
Linkage Disequilibrium ◽  
High Density ◽  
Simmental Cattle ◽  
Snp Panels

Marker-to-marker linkage disequilibrium on chromosomes 5q, 6p, and 8p in Irish high-density schizophrenia pedigrees

1999 ◽  
Vol 88 (1) ◽  
pp. 29-33 ◽  
Author(s):  
Kenneth S. Kendler ◽  
Charles J. MacLean ◽  
Yunlong Ma ◽  
F. Anthony O'Neill ◽  
Dermot Walsh ◽  
...  
Keyword(s):  
Linkage Disequilibrium ◽  
High Density

scholarly journals Extent of genome-wide linkage disequilibrium in Australian Holstein-Friesian cattle based on a high-density SNP panel

BMC Genomics ◽  
2008 ◽  
Vol 9 (1) ◽  
pp. 187 ◽  
Author(s):  
Mehar S Khatkar ◽  
Frank W Nicholas ◽  
Andrew R Collins ◽  
Kyall R Zenger ◽  
Julie AL Cavanagh ◽  
...  
Keyword(s):  
Linkage Disequilibrium ◽  
High Density ◽  
Genome Wide ◽  
Holstein Friesian ◽  
Snp Panel ◽  
Friesian Cattle ◽  
Genome Wide Linkage Disequilibrium

scholarly journals SNP panels for the estimation of dairy breed proportion and parentage assignment in African crossbred dairy cattle

2021 ◽  
Vol 53 (1) ◽  
Author(s):  
Netsanet Z. Gebrehiwot ◽  
Eva M. Strucken ◽  
Karen Marshall ◽  
Hassan Aliloo ◽  
John P. Gibson
Keyword(s):  
Allele Frequency ◽  
Bos Taurus ◽  
Low Cost ◽  
Bos Indicus ◽  
High Density ◽  
Indigenous Populations ◽  
Genetic Admixture ◽  
Genotype Data ◽  
Parentage Assignment ◽  
Snp Panels

Abstract Background Understanding the relationship between genetic admixture and phenotypic performance is crucial for the optimization of crossbreeding programs. The use of small sets of informative ancestry markers can be a cost-effective option for the estimation of breed composition and for parentage assignment in situations where pedigree recording is difficult. The objectives of this study were to develop small single nucleotide polymorphism (SNP) panels that can accurately estimate the total dairy proportion and assign parentage in both West and East African crossbred dairy cows. Methods Medium- and high-density SNP genotype data (Illumina BovineSNP50 and BovineHD Beadchip) for 4231 animals sampled from African crossbreds, African Bos taurus, European Bos taurus, Bos indicus, and African indigenous populations were used. For estimating breed composition, the absolute differences in allele frequency were calculated between pure ancestral breeds to identify SNPs with the highest discriminating power, and different combinations of SNPs weighted by ancestral origin were tested against estimates based on all available SNPs. For parentage assignment, informative SNPs were selected based on the highest minor allele frequency (MAF) in African crossbred populations assuming two Scenarios: (1) parents were selected among all the animals with known genotypes, and (2) parents were selected only among the animals known to be a parent of at least one progeny. Results For the medium-density genotype data, SNPs selected for the largest differences in allele frequency between West African indigenous and European Bos taurus breeds performed best for most African crossbred populations and achieved a prediction accuracy (r2) for breed composition of 0.926 to 0.961 with 200 SNPs. For the high-density dataset, a panel with 70% of the SNPs selected on their largest difference in allele frequency between African and European Bos taurus performed best or very near best across all crossbred populations with r2 ranging from 0.978 to 0.984 with 200 SNPs. In all African crossbred populations, unambiguous parentage assignment was possible with ≥ 300 SNPs for the majority of the panels for Scenario 1 and ≥ 200 SNPs for Scenario 2. Conclusions The identified low-cost SNP assays could overcome incomplete or inaccurate pedigree records in African smallholder systems and allow effective breeding decisions to produce progeny of desired breed composition.

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