scholarly journals Cloning of cDNA Encoding PAS-4 Glycoprotein, an Integral Glycoprotein of Bovine Mammary Epithelial Cell Membrane

2002 ◽  
Vol 15 (4) ◽  
pp. 576-584
Author(s):  
Sik Hwangbo ◽  
Soo-Won Lee ◽  
Chouemon Kanno
Keyword(s):  
Epithelial Cell ◽  
Cell Membrane ◽  
Mammary Epithelial Cell ◽  
Mammary Epithelial ◽  
Bovine Mammary Epithelial Cell

scholarly journals Genome-Wide Analysis of LncRNA in Bovine Mammary Epithelial Cell Injuries Induced by Escherichia Coli and Staphylococcus Aureus

2021 ◽  
Vol 22 (18) ◽  
pp. 9719
Author(s):  
Changjie Lin ◽  
Yifan Zhu ◽  
Zhiyu Hao ◽  
Haojun Xu ◽  
Ting Li ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Epithelial Cell ◽  
Mammary Epithelial Cell ◽  
Molecular Mechanisms ◽  
Bovine Mastitis ◽  
Mammary Epithelial ◽  
E Coli ◽  
Bovine Mammary Epithelial Cell ◽  
And Staphylococcus Aureus

Escherichia coli and Staphylococcus aureus are two common pathogenic microorganisms that cause mastitis in dairy cows. They can cause clinical mastitis and subclinical mastitis. In recent studies, lncRNAs have been found to play an important role in the immune responses triggered by microbial inducers. However, the actions of lncRNAs in bovine mastitis remain unclear. The purpose of this study was to investigate the effects of bovine mammary epithelial cell injuries induced by treatment with E. coli and S. aureus, and to explore the lncRNA profile on cell injuries. The lncRNA transcriptome analysis showed a total of 2597 lncRNAs. There were 2234 lncRNAs differentially expressed in the E. coli group and 2334 in the S. aureus group. Moreover, we found that the E. coli and S. aureus groups of maternal genes targeted signaling pathways with similar functions according to KEGG and GO analyses. Two lncRNA–miRNA–mRNA interaction networks were constructed in order to predict the potential molecular mechanisms of regulation in the cell injuries. We believe that this is the first report demonstrating the dysregulation of lncRNAs in cells upon E. coli and S. aureus infections, suggesting that they have the potential to become important diagnostic markers and to provide novel insights into controlling and preventing mastitis.

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