scholarly journals Post-prandial decrease in plasma growth hormone levels is not related to the increase in plasma insulin levels in goats

2017 ◽  
Vol 30 (12) ◽  
pp. 1696-1701
Author(s):  
Koki Nishihara ◽  
Ryoko Kobayashi ◽  
Yutaka Suzuki ◽  
Katsuyoshi Sato ◽  
Kazuo Katoh ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Plasma Insulin ◽  
Plasma Growth Hormone ◽  
Hormone Levels ◽  
Insulin Levels ◽  
Plasma Insulin Levels

PLASMA INSULIN AND GROWTH HORMONE CONCENTRATIONS IN PREGNANT SHEEP I:

1976 ◽  
Vol 82 (2) ◽  
pp. 544-552 ◽  
Author(s):  
Knut Hove ◽  
Anne Kristine Blom
Keyword(s):  
Growth Hormone ◽  
Plasma Insulin ◽  
Late Pregnancy ◽  
Plasma Growth Hormone ◽  
Energy Substrate ◽  
Insulin Levels ◽  
Pregnant Sheep ◽  
Plasma Insulin Levels ◽  
Insulin Responses ◽  
Substrate Concentrations

ABSTRACT Two or three foetal lambs regularly result in a varying degree of carbohydrate shortage in mother ewes in late pregnancy. We have investigated the correlation between plasma insulin, growth hormone and energy substrate concentrations in ewes 8 and 1 weeks before lambing. Plasma growth hormone was fairly constant (2–3 ng/ml) throughout the 24-h cycle 8 weeks before parturition. Seven weeks later higher average levels and increased diurnal fluctuations were observed in 3 out of 4 multiparous ewes. The average post-absorptive insulin levels were reduced by 50 per cent during the same interval. Simultaneously decreased post-absorptive sugar and increased acetoacetate levels were observed. It is concluded that the hormonal adaptations to the increasing carbohydrate deficit in late pregnancy, especially among multiparous ewes, include: a) reduced post-absorptive plasma insulin levels, b) reduced insulin responses to feeding, and c) increased levels of growth hormone in the plasma.

PLASMA INSULIN AND GROWTH HORMONE DURING 22-HOUR FASTS AND AFTER GRADED GLUCOSE LOADS IN SIX HEALTHY ADULTS

1968 ◽  
Vol 40 (3) ◽  
pp. 297-311 ◽  
Author(s):  
W. M. HUNTER ◽  
J. M. T. WILLOUGHBY ◽  
J. A. STRONG
Keyword(s):  
Growth Hormone ◽  
Blood Glucose ◽  
Plasma Insulin ◽  
Healthy Adults ◽  
Insulin Concentration ◽  
Stress Growth ◽  
Hormone Levels ◽  
Insulin Levels ◽  
External Events

SUMMARY Plasma insulin and growth hormone were measured by radioimmunoassay in healthy adults during the latter part of 22 hr. fasts and after graded glucose loads. The insulin concentration was less than 8 μ-u./ml. in all fasting samples and in samples taken after the blood glucose had returned to fasting levels. Insulin levels increased with increasing glucose loads. During fasting, growth hormone showed intermittently raised secretion; in some subjects high values were reached at times which could not be related to external events or to stress. Growth hormone levels were consistently low during the absorption of glucose but rose immediately thereafter. This rise occurred increasingly late and reached increasing levels as the glucose loads were made progressively larger. Insulin had almost invariably returned to fasting levels before the growth hormone concentrations began to rise.

Insulin-independent glucose uptake in growth hormone treated dairy cows

1998 ◽  
Vol 65 (3) ◽  
pp. 423-431 ◽  
Author(s):  
MICHAEL T. ROSE ◽  
FUMIAKI ITOH ◽  
MITSUTO MATSUMOTO ◽  
YUJI TAKAHASHI ◽  
YOSHIAKI OBARA
Keyword(s):  
Growth Hormone ◽  
Dairy Cows ◽  
Glucose Uptake ◽  
Plasma Insulin ◽  
Whole Body ◽  
Glucose Disposal ◽  
Glucose Turnover ◽  
Insulin Levels ◽  
Elevated Glucose ◽  
Plasma Insulin Levels

Our aim was to determine the effect of growth hormone on non-insulin-mediated glucose disposal in lactating dairy cows. Following 5 d of subcutaneous injections of either saline or growth hormone, insulin, somatostatin or insulin plus somatostatin were infused for 2 h each, in a series of experiments. Coincident with this, unlabelled glucose was infused at a variable rate to maintain a constant plasma glucose concentration. Glucose, doubly labelled with deuterium, was also infused for the calculations of glucose turnover. Plasma insulin levels were reduced to nearly zero by the infusion of somatostatin; under such conditions whole body glucose disposal should be non-insulin-mediated. Dairy cows treated with growth hormone, which had significantly increased milk yields on the day before the experimental infusions, did not have different levels of whole body non-insulin-mediated glucose disposal when expressed in absolute terms. Growth hormone did not affect non-mammary non-insulin-mediated glucose uptake estimated by calculation. Growth hormone significantly inhibited insulin-mediated glucose uptake when plasma insulin levels were elevated. Glucose uptake during insulin plus somatostatin infusion was not significantly different from that of the insulin only infusion.

THE EFFECT OF THE PROGESTOGEN ETHYNODIOL DIACETATE ON GLUCOSE, INSULIN, AND GROWTH HORMONE AFTER SIX MONTHS TREATMENT

1972 ◽  
Vol 70 (2) ◽  
pp. 373-384 ◽  
Author(s):  
W. N. Spellacy ◽  
W. C. Buhi ◽  
S. A. Birk
Keyword(s):  
Growth Hormone ◽  
Blood Glucose ◽  
Plasma Insulin ◽  
Tolerance Test ◽  
Metabolic Effects ◽  
Oral Glucose ◽  
Hormone Levels ◽  
Glucose Levels ◽  
Ethynodiol Diacetate ◽  
Tolerance Curve

ABSTRACT Seventy-one women were treated with a daily dose of 0.25 mg of the progestogen ethynodiol diacetate. They were all tested with a three-hour oral glucose tolerance test before beginning the steroid and then again during the sixth month of use. Measurements were made of blood glucose and plasma insulin and growth hormone levels. There was a significant elevation of the blood glucose levels after steroid treatment as well as a deterioration in the tolerance curve in 12.9% of the women. The plasma insulin values were also elevated after drug treatment whereas the fasting ambulatory growth hormone levels did not significantly change. There was a significant association between the changes in glucose and insulin levels and the subject's age, control weight, or weight gain during treatment. The importance of considering the metabolic effects of the progestogen component of oral contraceptives is stressed.

scholarly journals Lower plasma insulin levels during overnight closed-loop in school children with type 1 diabetes: Potential advantage? A randomized cross-over trial

PLoS ONE ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. e0212013 ◽  
Author(s):  
Ulrike Schierloh ◽  
Malgorzata E. Wilinska ◽  
Ineke M. Pit-ten Cate ◽  
Petra Baumann ◽  
Roman Hovorka ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
School Children ◽  
Plasma Insulin ◽  
Closed Loop ◽  
Lower Plasma ◽  
Insulin Levels ◽  
Plasma Insulin Levels

Metformin decreases plasma insulin levels and systolic blood pressure in spontaneously hypertensive rats

1994 ◽  
Vol 267 (4) ◽  
pp. H1250-H1253 ◽  
Author(s):  
S. Verma ◽  
S. Bhanot ◽  
J. H. McNeill
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Plasma Insulin ◽  
Metformin Treatment ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Insulin Levels ◽  
Plasma Insulin Levels ◽  
Wistar Kyoto

To determine the relationship between hyperinsulinemia and hypertension in spontaneously hypertensive rats (SHR), the antihyperglycemic agent metformin was administered to SHR and their Wistar-Kyoto (WKY) controls, and its effects on plasma insulin levels and blood pressure were examined. Five-week-old rats were started on oral metformin treatment (350 mg.kg-1.day-1, which was gradually increased to 500 mg.kg-1.day-1 over a 2-wk period). Metformin treatment caused sustained decreases in plasma insulin levels in the SHR (27.1 +/- 2.3 vs. untreated SHR 53.5 +/- 2.7 microU/ml, P < 0.001) without having any effect in the WKY (30.7 +/- 2.2 vs. untreated WKY 37.8 +/- 1.6 microU/ml, P > 0.05). The treatment did not affect the plasma glucose levels in any group. Metformin treatment also attenuated the increase in systolic blood pressure in the SHR (157 +/- 6.0 vs. untreated SHR 196 +/- 9.0 mmHg, P < 0.001) but had no effect in the WKY (134 +/- 3 vs. untreated WKY 136 +/- 4 mmHg, P > 0.05). Furthermore, raising plasma insulin levels in the metformin-treated SHR to levels that existed in the untreated SHR reversed the effect of metformin on blood pressure (189 +/- 3 vs. untreated SHR 208 +/- 5.0 mmHg, P > 0.05). These findings suggest that either hyperinsulinemia may contribute toward the increase in blood pressure in the SHR or that the underlying mechanism is closely associated with the expression of both these disorders.

CHANGES IN PLASMA GROWTH HORMONE LEVELS IN RETARDED CHILDREN

2008 ◽  
Vol 12 (3-4) ◽  
pp. 294-306
Author(s):  
J. HILLMAN ◽  
J. HAMMOND ◽  
J. SOKOLA ◽  
M. REISS
Keyword(s):  
Growth Hormone ◽  
Plasma Growth Hormone ◽  
Hormone Levels

GLUCOSE DISAPPEARANCE RATE IN SYMPTOMATIC NEONATAL HYPOGLYCEMIA

PEDIATRICS ◽  
1973 ◽  
Vol 52 (1) ◽  
pp. 75-82
Author(s):  
Rosita S. Pildes ◽  
Daksha A. Patel ◽  
Menachem Nitzan
Keyword(s):  
Growth Hormone ◽  
Plasma Insulin ◽  
Newborn Infants ◽  
Glucose Disposal ◽  
Disappearance Rate ◽  
Neonatal Hypoglycemia ◽  
Plasma Growth Hormone ◽  
Intravenous Glucose ◽  
Glucose Disappearance

The present study was undertaken to determine the rate of glucose disposal in the pathogenesis of symptomatic neonatal hypoglycemia. Intravenous glucose (1 gm/kg) was injected rapidly into 11 hypoglycemic and eight control newborn infants. The percentage (mean ± SEM) disappearance rate per minute (Kt) was significantly higher (p &lt; 0.001) in the hypoglycemic newborn infants compared with that of the controls (2.8 ± 0.1 versus 1.2 ± 0.1, respectively). Baseline plasma insulin concentrations were significantly higher (p &lt; 0.01) in the hypoglycemic (16.8 ± 3.9µU/ml) than those of the controls (3.5 ± 1.0µU/ml). Baseline plasma growth hormone values in the hypoglycemic newborns were 16.6 ± 5.7 mµg/ml. Growth hormorne values rose in the hypoglycemic to 36 ± 10 mµg/ml at 10 minutes and to 64 ± 13 mµg/ml by 60 minutes.

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