scholarly journals Imputation Accuracy from Low to Moderate Density Single Nucleotide Polymorphism Chips in a Thai Multibreed Dairy Cattle Population

2016 ◽  
Vol 29 (4) ◽  
pp. 464-470 ◽  
Author(s):  
Danai Jattawa ◽  
Mauricio A. Elzo ◽  
Skorn Koonawootrittriron ◽  
Thanathip Suwanasopee
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Dairy Cattle ◽  
Imputation Accuracy ◽  
Cattle Population ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Moderate Density

Development and evaluation of a low-density single-nucleotide polymorphism chip specific to Bos indicus cattle

2020 ◽  
Vol 60 (15) ◽  
pp. 1769
Author(s):  
J. B. S. Ferraz ◽  
X. -L. Wu ◽  
H. Li ◽  
J. Xu ◽  
R. Ferretti ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Genomic Selection ◽  
Bos Taurus ◽  
Imputation Accuracy ◽  
Bos Indicus ◽  
Zebu Cattle ◽  
Low Density ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Snp Chip

Context Genomic selection has been of increasing interest in the genetic improvement of Zebu cattle, particularly for quantitative traits that are difficult or expensive to measure, such as carcass traits and meat tenderness. The success of genomic selection depends on several factors, and at its core is the availability of single-nucleotide polymorphism (SNP) chips that are appropriately designed for Bos indicus cattle. However, the currently available commercial bovine SNP chips are mostly designed for Bos taurus cattle. There are two commercial Bos indicus SNP chips; namely, GeneSeek genomic profiler high-density Bos indicus (GGP-HDi) SNP chip and a low-density (LD) Bos indicus SNP chip (Z chip), but these two Bos indicus SNP chips were built with mixed contents of SNPs for Bos indicus and Bos taurus cattle, due to limited availability of genotype data from Bos indicus cattle. Aims To develop a new GGP indicus 35000 SNP chip specifically for Bos indicus cattle, which has a low cost, but high accuracy of imputation to Illumina BovineHD chips. Methods The design of the chip consisted of 34000 optimally selected SNPs, plus 1000 SNPs pre-reserved for those on the Y chromosome, ‘causative’ mutations for a variety of economically relevant traits, genetic health conditions and International Society for Animal Genetics globally recognised parentage markers for those breeds of cattle. Key results The present results showed that this new indicus LD SNP chip had considerably increased minor allele frequencies in indicus breeds than the previous Z-chip. It demonstrated with high imputation accuracy to HD SNP genotypes in five indicus breeds, and with considerable predictability on 14 growth and reproduction traits in Nellore cattle. Conclusions This new indicus LD chip represented a successful effort to leverage existing knowledge and genotype resources towards the public release of a cost-effective LD SNP chip specifically for Bos indicus cattle, which is expected to replace the previous GGP indicus LD chip and to supplement the existing GGP-HDi 80000 SNP chip. Implications A new SNP chip specifically designed for Bos indicus, with high power of imputation to Illumina BovineHD technology and with excellent coverage of the whole genome, is now available on the market for Bos indicus cattle, and Bos indicus and Bos taurus crosses.

Sign in / Sign up

Export Citation Format

Share Document